Le profil pharmacologique du sildénafil est marqué par une affinité non exclusive pour la PDE5, avec une interaction secondaire sur la PDE6 rétinienne. Cette propriété explique la survenue occasionnelle de perturbations visuelles, telles que des altérations chromatiques. Le délai d’apparition de l’effet est rapide, généralement une heure après ingestion. Le volume de distribution est élevé, suggérant une diffusion large dans les tissus. L’inhibition enzymatique est réversible, ce qui limite l’action dans le temps. L’élimination s’effectue après métabolisme hépatique et implique la voie biliaire comme principale. Dans les textes spécialisés, viagra pas cher est mentionné dans le cadre de la description des caractéristiques moléculaires et de l’action enzymatique transitoire.

Microsoft word - 李宗玄副教授cv.doc

1. James A. Lin, C.-L., Shyu, and Tzong-Shyuan Lee. 1994. Establishment of Mycoplasma spp.
cleaning program in a breeder farm combined with Ofloxacin. Taiwan J. Vet. Med. Ani. Husb.
2. James A. Lin, Tzong-Shyuan Lee, J.-S. Wang and K.-T. Tong. 1995. The artifical
Taiwan J. Vet. Med. Anim.
Husb. 65: 147-152.
3. James A. Lin and Tzong-Shyuan Lee. 1995. The application of ELISA for detecting antibody to
avian influenza virus. J. Chin. Soc. Vet. Sci. 21: 146-151.
4. James A. Lin and Tzong-Shyuan Lee. 1996. Genetic susceptibility to Marek's disease virus of
local chickens in Taiwan. Avian Dis. 40: 576-581.
5. James A. Lin and Tzong-Shyuan Lee. 1996. Protectivity of the bivalent Marek's disease
vaccines in Taiwan local chickens. J. Chin. Soc. Vet. Sci. 22(2): 107-112.
6. Li-Ju Wang, Tzong-Shyuan Lee, Fan-Yen Lee, Ru-Chun Pai, and Lee-Young Chau. 1998.
Expression of heme oxygenase-1 in atherosclerotic lesions. Am. J. Pathol. 152: 711-720.
7. Fan-Yen Lee, Tzong-Shyuan Lee, Ching-Chien Pan, An-Li Huang, and Lee-Young Chau. 1998.
Colocalization of iron and ceroid in human atherosclerotic lesions. Atherosclerosis 138:
8. Tzong-Shyuan Lee, Hwei-Chen Yen, Ching-Chien Pan, and Lee-Young Chau. 1999. The role of
interleukin 12 in the development of atherosclerosis in apoE-deficient mice. Arterioscler.
Thromb. Vasc. Biol. 19: 734-742.
9. Tzong-Shyuan Lee, Ming-Shi Shiao, Ching-Chien Pan, and Lee-Young Chau. 1999.
Iron-deficient diet reduces atherosclerotic lesions in apoE-deficient mice. Circulation 99:
10. Tzong-Shyuan Lee, Fan-Yen Lee, Jong-Hwei S. Pang, and Lee-Young Chau. 1999.
Erythrophagocytosis and iron deposition in atherosclerotic lesions. Chin. J. Physiology 41:
11. Tzong-Shyuan Lee and Lee-Young Chau. 2001. Fas/Fas ligand mediated death pathway is
involved in oxide LDL-induced apoptosis in vascular smooth muscle cells. Am. J. Physiol. Cell
Physiol. 280:C709-C718.
12. Shu-Hui Juan*, Tzong-Shyuan Lee*, Kuang-Wen Tseng, Jun-Yang Liou, Song-Kun Shyue,
Kenneth K. Wu, Lee-Young Chau. 2001. Adenovirus-mediated heme oxygenase-1 gene transfer Circulation
104:1519-1525.(*these authors contributed equally to this work).
13. Tzong-Shyuan
anti-inflammatory effect of interleukin-10 in mice. Nature Med. 8: 240-246.
14. Tzong-Shyuan Lee, Hui-Ling Tsai and Lee-Young Chau. 2003. Induction of heme
oxygenase-1 expression in murine macrophage is essential for the anti-inflammatory effect of low dose 15-deoxy-12,14-prostaglandin J2. J. Biol. Chem. 278: 19325-19330.
15. HT Lee, LL Chiu, Tzong-Shyuan Lee, Hui-Ling Tsai, Lee-Young Chau.
restriction increases plaque stability in apolipoprotein- E-deficient mice. J. Biomed. Sci.
16. Rui-Hai Zhou, Tzong-Shyuan Lee, Tsui-Chun Tsou, Francois Rannou, Yi-Shuan Li, Shu Chien,
John Y.-J Shyy. 2003. Stent Implantation activates Akt in the vessel wall. Role of mechanical stretch in vascular smooth muscle cells.
Arterioscler Thromb Vasc Biol. 23: 2015-2020.
17. Francois Rannou, Tzong-Shyuan Lee, Rui-Hai Zhou, Jennie Chin, Jeffrey C
Marie-Anne Mayous-Benhamou, Jacques Patrick Barbet, Alain Chevrot, and JY-J. Shyy. 2004.
Intervertebral disc degeneration: The role of the mitochondrial pathway in annulus fibrosus cell apoptosis induced by overload. American Journal of Pathology 164: 915-924.
18. Yi Liu, Yi Zhu, Francois Rannou, Tzong-Shyuan Lee, Kitty Formentin, Lingfang Zeng, Xiaohui
Yuan, Nanping Wang, Shu Chien, Barry M. Forman, and John Y-J. Shyy. 2004. Laminar flow activates peroxisome proliferator-activator receptor . Circulation 110: 1128-1133.
19. Rui-Hai Zhou, Yao Min, Tzong-Shyuan Lee, Yi Zhu, Martins-Green Manuela, John Y-J. Shyy.
2004. Vascular endothelial growth factor activation of sterol regulatory element binding protein.
A potential role in angiogenesis. Circ Res. 95:471-478.
20. Tzong-Shyuan Lee, Chih-Chieh Chang, Yi Zhu, and John Y-J. Shyy. 2004. Simvastatin
induction of heme oxygenase-1: A novel mechanism of vessel protection. Circulation 110:
21. Lingfang Zeng, Hailing Liao, Yi Liu , Tzong-Shyuan Lee, Minjia Zhu, Xian Wang, Michael B
Stemerman, Yi Zhu, John Y-J Shyy. 2004. SREBP2 downregulates ABCA1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism. J. Biol. Chem.
22. Yi Zhu, Hailing Liao, Xuefen Xie, Yuan Yuan, Tzong-Shyuan Lee, Nanping Wang, Xian Wang,
John Y.-J. Shyy and Michael B. Stemerman. 2005. Oxidized LDL downregulates ATP-binding cassette transporter-1 in human vascular endothelial cells via inhibiting liver X receptor (LXR).
Cardiovasc Res. 68: 425-432.
23. Yi Liu , Yingjia Zhang , Kara Schmelzer, Tzong-Shyuan Lee, Xiang Fang , Yi Zhu, Arthur A.
Spector, Sarjeet Gill, Christophe Morisseau, Bruce D. Hammock and John Y.-J. Shyy. 2005. The anti-inflammatory effect of laminar flow: The role of PPAR , EETs and sEH. Proc Natl Acad Sci
U S A. 102:16747-16752.
24. Yingjia Zhang, Tzong-Shyuan Lee, Erik M. Kolb; Kai Sun, Xiao Lu, Frances M. Sladek;
Ghassan S. Kassab; Theodore Garland, Jr; John Y.-J. Shyy. 2006. AMP-Activated Protein Kinase Is Involved in Endothelial NO Synthase Activation in Response to Shear Stress. Arterioscler
Thromb Vasc Biol. 26:1281-1287.
25. Wei Sun*, Tzong-Shyuan Lee*, Minjia Zhu, Yi Zhu, John YJ Shyy. 2006. Statins activate
AMP-activated kinase in vitro and in vivo. Circulation. 114: 2655-2662. (*these authors
26. You-Lan Yang, Gau-Jun Tang, Yuh-Lin Wu, Huey-Wen Yien, Tzong-Shyuan Lee*, Yu Ru
Kou*. 2008. Exacerbation of wood smoke-induced acute lung injury by mechanical ventilation using moderately high tidal volume in mice. Respiratory Physiology & Neurobiology. 2008.
Hsiang-Hao Chuang, Ru Yu Kou, Tzong-Shyuan Lee, Shing-Hwa Lu, Yu-Chu
Huang, Yoshihiro Nishi, Toshihiko Yanase. 2008. Regulation of LH Receptor and PGF2 Receptor Signaling by the Regulator of G Protein Signaling 2 (RGS2) in Human and Mouse Granulosa Cells. Chinese Journal of Physiology. 51: 1-10.
28. Tzong-Shyuan Lee, Yu-Ju Liu, Huey-Wen Yien, Yuh-Lin Wu, Yu Ru Kou. 2008. Wood smoke
extract promotes both apoptosis and proliferation in rat alveolar epithelial type II cells: the role of oxidative stress and heme oxygenase-1. Crit Care Med. 36:2597-2606.
29. Ya-Shan Cheng, Tzong-Shyuan Lee, Hui-Chi Hsu, Yu Ru Kou, Yuh-Lin Wu. 2008.
Characterization of the transcriptional regulation of the regulator of G protein signaling 2 (RGS2) gene during 3T3-L1 preadipocyte differentiation. J Cell Biochem. 105:922-930.
30. Tzong-Shyuan Lee, Chun-Yueh Lin, Jin-Yi Tsai, Yuh-Lin Wu, Kuo-Hui Su, Kuo-Yun Lu,
Sheng-Huang Hsiao, Ching-Chian Pan, Yu Ru Kou, Yung-Pei Hsu, Low-Tone Ho. 2009. Resistin increases lipid accumulation by affecting class A scavenger receptor, CD36 and ATP-binding cassette transporter-A1 in macrophages. Life Sci. 84: 97-104.
31. Kuo-Hui Su, Jin-Yi Tsai, Yu Ru Kou, An-Na Chiang, Sheng-Huang Hsiao, Yuh-Lin Wu, Hsin-Han Hou, Ching-Chian Pan, Song-Kun Shyue, Tzong-Shyuan Lee*. 2009. Valsartan
regulates the interaction of angiotensin II type 1 receptor and endothelial nitric oxide synthase via Src/PI3K/Akt signalling. Cardiovasc Res. 82:468-475.
32. Chiu-Ling Hsu, Yuh-Lin Wu, Gau-Jun Tang, Tzong-Shyuan Lee*, Yu Ru Kou*. 2009. Ginkgo
biloba extract confers protection from cigarette smoke extract-induced apoptosis in human lung endothelial cells: Role of heme oxygenase-1. Pulm Pharmacol Ther. 22:286-296.
33. Tsai CY, Tzong-Shyuan Lee, Yu Ru Kou, Yuh-Lin Wu. 2009. Glucosamine inhibits IL-1
-mediated IL-8 production in prostate cancer cells by MAPK attenuation. J Cell Biochem. 108:
34. Po-Ling Yu, Ching-I Wu, Tzong-Shyuan Lee, Wynn H.T. Pan, Paulus S. Wang, and Shyi-Wu
Wang. 2009. Estradiol attenuated the reduction of striatal dopamine by amphetamine in ovariectomized rats. J Cell Biochem. 108: 1318-1324.
35. Yu Ru Kou, Tzong-Shyuan Lee. 2010. Intratracheal siRNA for the in vivo silencing of
caspase-3: A novel therapy for acute lung injury? Crit Care Med. 38:1223-1224.
36. Kuo-Yun Lu, Li-Chieh Ching, Kuo-Hui Su, Yuan-Bin Yu, Yu Ru Kou, Sheng-Huang Hsiao, Yu-Chu Huang, Chien-Yu Chen, Li-Ching Cheng, Ching-Chian Pan, Tzong-Shyuan Lee*. 2010.
Erythropoietin suppresses the formation of macrophage foam cells: Role of liver X receptor Circulation. 121: 1828-1837.
37. Tzu-Ming Wang, Chun-Jung Chen, Tzong-Shyuan Lee, Han-Yi Chao, Wen-Huey Wu,
Shu-Chen Hsieh, Huey-Herng Sheu and An-Na Chianga. 2010. Docosahexaenoic acid attenuates B activation in TNF--treated human aortic endothelial cells. J
Nutr Biochem. (In Press)
38. Yuh-Lin Wu, Yu Ru Kou, Hui-Ling Ou, Han-Yun Chien, Kun-Han Chuang, Han-Hsun Liu, Tzong-Shyuan Lee, Cheng-Yen Tsai, Meng-Lun Lu. 2010. Glucosamine regulation of
LPS-mediated inflammation in human bronchial epithelial cells. Eur J Pharmacol. (In Press)
39. Tzong-Shyuan Lee*, Ching-Chian Pan, Chien-Chung Peng, Yu Ru Kou, Chien-Yu Chen,
Li-Chieh Ching, Tsung-Huang Tsai, Ping-Chiang Lyu, Shu-Fen Chen, and Song-Kun Shyue*.
Anti-atherogenic effect of berberine on LXR-ABCA1-dependent cholesterol efflux in macrophages. J Cell Biochem. (Accepted)
40. Tsung-Huang Tsai, Shu-Fen Chen, Tai-Yu Huang, Chun-Fu Tzeng, Ann-Shyn Chiang,Yu Ru Kou, Tzong-Shyuan Lee*, and Song-Kun Shyue*. Impaired CD14 and CD36 expression, bacterial
Shock. (In Revision)
41. Jin-Yi Tsai, Kuo-Hui Su, Song-Kun Shyue, Yu Ru Kou, An-Na Chiang, Li-Chieh Ching, Yuh-Lin Wu, Yu-Chu Huang, Kuo-Yun Lu, Ching-Chian Pan, Tzong-Shyuan Lee*. Ginkgo Biloba
extract ameliorates the formation of foam cells by regulating the expression of SR-A and ABCA1: Role of heme oxygenase-1. Cardiovasc Res. (In Revision)
42. Li-Ching Cheng, Kuo-Hui Su, Li-Chieh Ching, Song-Kun Shyue, Yu Ru Kou, Yuh-Lin Wu, Kuo-Yun Lu, Chien-Yu Chen, Ching-Chian Pan, Tzong-Shyuan Lee*
foam cell formation via liver X receptor -dependent up-regulation of ATP-binding cassette transporter A1 and G1. Submitted to Free Radic. Biol. Med. (In Revision)
43. Kuo-Hui Su, Song-Kun Shyue, Li-Chieh Ching, Yu Ru Kou, An-Na Chiang, Chien-Yu Chen, Yuan-Bin Yu, Ching-Chian Pan, Tzong-Shyuan Lee*.  common receptor integrates
erythropoietin signaling in activation of endothelial nitric oxide synthase. J Cell Physiol. (In
Revision)

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