Microsoft word - munzenmaier dhm curriculum vitae.doc
Diane H. Munzenmaier, Ph.D. Office Address: Place of Birth:
4. Citizenship: U.S.A. 5. Education:
Postgraduate Training: 05/1995 – 06/1999
Postdoctoral Fellow Medical College of Wisconsin Cardiovascular Research Center Milwaukee, WI
7. Faculty Appointments: 07/2009 – present
Education Coordinator Human and Molecular Genetics Center
Assistant Professor of Physiology Human and Molecular Genetics Center
8. Awards and Honors:
Caroline tum Suden Professional Opportunity Award
Caroline tum Suden/Francis A. Hellebrandt Award
Merck Young Investigator Award for Excellence in
American Heart Association High Blood Pressure Council Memberships in Professional and Honorary Societies:
American Heart Association - Stroke Council American Physiological Society Microcirculatory Society Wisconsin Association for Biomedical Research and Education
Editorial Peer Reviewer:
Advances in Physiology Education American Journal of Physiology: Comparative and Regulatory Physiology American Journal of Physiology: Heart and Circulatory Physiology Circulation Circulation Research European Journal of Neurology Hypertension Kidney International Microcirculation Physiological Genomics National Elected/Appointed Leadership and Committee Positions:
04/2007 Reviewer, NIAID-funded Center for Medical Countermeasures
against Radiological Terrorism (CMCRT) Pilot Research Grants Program
Reviewer, NIH Study Section, SBIR/STTR Special Emphasis Panel, Cardiovascular Sciences Small Business Activities Judge, David S. Bruce Undergraduate Research Award, American Physiological Society Education Committee. Voted on 12 finalists to present research at Experimental Biology meeting. Part of a committee that judged final presentations and chose four award winners.
Member, Steering Committee for the 8th World Congress for Microcirculation to be held in Milwaukee, August 2007.
6/2004 – 08/2007 Chair, Social Subcommittee for the 8th World Congress for
Microcirculation to be held in Milwaukee, August 2007.
Member, Facilities Subcommittee for the 8th World Congress for Microcirculation to be held in Milwaukee, August 2007. Chair, Subcommittee for the development of “Physiology Understanding Week” (“PhUn Week”), American Physiological Society Education Committee. Submitted proposal to APS Council for development of a $10,000 pilot program to encourage K-12 outreach by APS members which was tested Nov 2005. Expansion of program to entire APS membership has been approved by APS council and is currently being further developed and tested. http://www.the-aps.org/education/PhUnWeek.htm Member, Education Committee, American Physiological Society Research Grants, Contracts, Awards, Projects: Peer Review A. Active Title: Rat Genome Database
Title: Intracellular Mechanisms of the Effects of Angiotensin II on Blood Vessel Growth
Source: American Heart Association Predoctoral Fellowship, #93-F-Pre-12
Title: The Role of Angiotensin II Subtypes in Angiogenesis of the Microcirculation
Source: American Heart Association Predoctoral Fellowship, #94-Pre-10
Source: NIH National Research Service Award, #1 T32 HL007792-01
Title: Differential Regulation of Angiotensin II Receptor Subtypes as a Consequence of
Source: American Heart Association Postdoctoral Fellowship, #95-Post-29
6 4 Integrins in Hypoxia-induced Cerebral Angiogenesis
Source: American Heart Association Scientist Development Award, #9930342A
Title: Frontiers in Physiology Professional Opportunity Award
Role: Mentor to Cecilia Stingley, high school teacher
Title: Blood Pressure – Determinants and Controllers (Cowley) Project 5: Sodium Intake and ANG II in Microvascular Rarefaction
Title: National Heart, Lung, Blood Institute Proteomics Initiative (Greene)
C. Pending Title: Translational genetics of diabetes, obesity, and the metabolic syndrome Invited lectures/Workshops/Presentations/Site Visits: International Platform presenter “Angiotensin II Receptor Blockade Increases Cerebral Microvessel Density in Rats.”
XXIst International Symposium on Cerebral Blood Flow and Metabolism
Rat Genome Database Blood Pressure Regulation Ontology Development
Medical College of Wisconsin, June 25-26, 2008.
Platform presenter “An interactive, clinical case study, computer module for teaching medical genetics using genomic sequence analysis tools.” Experimental Biology, New Orleans, 2009. Regional Invited speaker “Angiotensin: Regulation and Function in the Cardiovascular System” Midwest Physiology Society Symposium Medical College of Wisconsin, Feb. 15, 1995 Invited speaker “Medical School Admissions at MCW” Summer Program for Undergraduate Research (SPUR) Seminar Series Medical College of Wisconsin, Summers 2004-06 14. Medical College of Wisconsin Committees/Service: 07/2009 – 06/2010 Graduate Studies Council Awards Committee, Chair
Organized judging of ~70 graduate student posters for 1st Annual “Research Day” event, 9/16/09. Responsible for travel award and dissertation award judging.
Institutional Animal Care and Use Committee, Alternate Member – same responsibilities as Scientist Member (below), fewer required review meetings. Institutional Animal Care and Use Committee, Scientist Member - responsible for semi-annual program evaluation as well as review and approval of animal use research proposals as well as numerous other responsibilities. Medical Scientist Training Program (MSTP) Interviewer – Conduct interviews with MSTP applicants and evaluate their suitability for the program. Graduate Studies Council Awards Committee– Judge presentations and choose award winners at the annual graduate student poster session and for travel award winners throughout the year. Junior Faculty representative at LCME site visit – Met with site visit examiners to answer questions regarding the experience of young faculty members at MCW and the role of MCW in faculty development. Bioengineering and Biotechnology Center Business Manager Search Committee – Interviewed 18 pre-screened applicants for Position and made recommendations on suitability for hire. Medical School Admissions Screening Subcommittee – Involved in setting new guidelines for screening of applications in order to enhance the ability of the committee to improve the quality and diversity of the medical school class. LCME Subcommittee on Graduate Educationin the Basic Sciences and Research – Selected to help develop the report that was submitted for the Liaison Committee for Medical Education (LCME) accreditation review. Medical School Admissions Committee - Involved in interviewing medical school applicants throughout the school year and making decisions regarding their potential for admission to the upcoming class. Elected to 2nd term in 2004. Elected to “Extended Service” position in 2007. Summer Program for Undergraduate Research (SPUR) presentation judge – Help to evaluate oral presentations of undergraduate students who had spent the summer doing research in an MCW laboratory. Department of Physiology Committees/Service: 03/2000 – present Physiology Graduate School Admissions Committee Involved in interviewing physiology graduate school applicants each spring and making decisions regarding their potential for admission to the upcoming class. Departmental Website committee
Developed plan and worked closely with website developers to create an updated departmental website initially released 10/2005.
Director, departmental cell culture core lab
Oversees lab and trains users of facility.
Medical College of Wisconsin Teaching Activities: Medical Student Education “Medical Physiology Laboratory” “Using Genomic Sequence in Diagnosis” Developed new laboraotryaught lab to first year medical students 03/2009. Undergoing further development for 2010. “Medical Physiology Laboratory” development Medical College of Wisconsin Department of Physiology “Using Genomic Sequence in Diagnosis” “Medical Physiology Laboratory” author/director
Medical College of Wisconsin Department of Physiology “Assessment and Analysis of Cardiovascular Function in the Pig”
“Medical Physiology Laboratory” instructor
Medical College of Wisconsin Department of Physiology
02/2002 – 02/2007 “Neuroscience” course lecturer
Medical College of Wisconsin Department of Cellular Biology, Neurobiology, and Anatomy
“Regulation of the Extracellular Environment in the CNS”
“Medical Physiology” course lecturer
Medical College of Wisconsin Department of Physiology “Cardiovascular Techniques”
“Medical Physiology” course lecturer
Medical College of Wisconsin Department of Physiology
Graduate Medical Education 08/2009 – present Residency Program Coordinator Development of new Clinical Genetics Residency with Pediatrics- Genetics to be submitted to ACGME for accreditation, July, 2010. Graduate Student Education 01/2010-05/2010 “Translational Genetics” course director and lecturer New requisite course for M.S. program in Clinical and Translational Science, CTSI
12/2009 “Endocrine Regulation” lecturer
Medical College of Wisconsin Department of Physiology, Second year Ph.D. student course
“Advanced Systems Physiology” lecturer/block director
Medical College of Wisconsin Department of Physiology, Second year Ph.D. student course
“Physiology of Aging” (PUBS 287) Undergraduate Education 01/1999 – 05/1999 “Neurobiology” lecturer (BIOL 155)
Marquette University Biology Department, Milwaukee, WI Upper level course, full semester, 38 lectures
Community/Lay Public Education 11/2008 Presenter, Physiology Understanding (PhUn) Week
Exercise Physiology course (50 high school upperclassmen)
Presenter, Physiology Understanding (PhUn) Week
Pilgrim Park Middle School, Elm Grove, WI 8th grade (total of 300 students)
Physiology Course instructor Biology Item Writer MCW Students, Faculty, Residents, or Fellows Mentored: 06/2000 – 08/2000 Summer research mentor Marques’ Williams, Milwaukee Technical High School Project SEED, minority mentoring program, American Chemical Society Frontiers in Physiology Mentor
Cecilia Stingley, high school science teacher
Ph.D. dissertation committee member Community Service Activities: 08/1990 – present Member, Marquette University “M” Club MUAthletics booster club comprised of former varsity athletes
Vice-President/President-Elect, 1996-97 President,
Member, Hall of Fame Selection Committee, 1999, 2006, 2009 Chair, Hall of Fame Selection Committee, 2011 induction
Chair, “Family Science” event, Special Judge Science Fair Judge Organizer, Turkey Trot Fun Run fundraiser for the Brookfield East High School Spartan Athletics Booster Club. Community Awards: All-American at Marquette University (total of 5 awards in Cross Country, Indoor & Outdoor Track).
09/1996 Inductee, Marquette University Athletics Hall of Fame
Member of 1982 National Champion Cross Country Team, Fifth place individual overall in national championship meet.
Hy Popuch Memorial Award Winner Awarded by the Marquette University “M” Club for service to the “M” Club and to Marquette University athletics.
12/2010 Inductee, Athletics Hall of Fame Bibliography Refereed Journal Publications/Original Papers:
1. Held-Munzenmaier, D., Olinger, G.N., Boerboom, L.E. A sheath for repetitive
insertion of high-fidelity micromanometer-tipped catheters. Am J Physiol 257(Heart Circ Physiol): H1312-H1314, 1989.
2. Munzenmaier, D.H., Greene, A.S. Angiotensin II mediates a sustained rise in nuclear
and cytoplasmic calcium via multiple receptor subtypes. Am J Physiol 269 (Heart Circ Physiol):H565-H570, 1995.
3. Munzenmaier, D.H., Greene, A.S. Opposing actions of angiotensin II on microvascular
growth and arterial blood pressure. Hypertension 27[part 2]:760-65, 1996.
4. Nora, E.H., Munzenmaier D.H., F.M. Hansen-Smith, J.H. Lombard, and A.S. Greene.
Localization of the angiotensin II type 2 receptor in the microcirculation of skeletal muscle. Am J Physiol (Heart Circ Physiol) 44:H1395-1403, 1998.
5. Munzenmaier, D.H., Harder, D.R. Cerebral microvascular endothelial cell tube
formation: effect of blockade of astrocytic epoxyeicosatrienoic acid production. Am J Physiol (Heart Circ Physiol) 278:H1163-7, 2000.
6. Santos, C.F., Caprio, M.A.V., Oliviera, E.B., Salgado, M.C.O., Schippers, D.N.,
Munzenmaier, D.H., and A.S. Greene. Functional role, cellular source and tissue distribution of rat elastase-2, an angiotensin II-forming enzyme. Am J Physiol (Heart Circ Physiol) 285:H775-83, 2003.
7. Forder J.P., Munzenmaier, D.H., Greene, A.S. Angiogenic protection from focal
ischemia with angiotensin II type 1 receptor blockade in the rat. Am J Physiol (Heart Circ Physiol), 288: H1989 - H1996, 2005.
8. Ardelt, A.A., McCullough, L.D., Korach, K.S., Wang, M.M., Munzenmaier, D.H.,
Hurn, P.D. Estradiol regulates angiopoietin-1 mRNA expression through estrogen receptor-α in a rodent experimental stroke model. Stroke 36:337-41, 2005.
9. Munzenmaier, D.H., Greene, A.S. Chronic angiotensin II AT1 receptor blockade
increases cerebral microvessel density. Am J Physiol (Heart Circ Physiol) 290: H512-H516, 2006.
10. Resende, M.M., Amaral, S.L., Munzenmaier, D.H., Greene, A.S. Role of endothelial
cell apoptosis in regulation of skeletal muscle angiogenesis during high and low salt intake. Physiol Genomics 25:325-35, 2006.
11. Petersen, M.C., Munzenmaier, D.H., Greene, A.S. Angiotensin II infusion restores
stimulated angiogenesis in the skeletal muscle of rats on a high-salt diet, Am J Physiol (Heart Circ Physiol) 291:114-20, 2006.
12. Munzenmaier, D.H. Help protect the future of physiology. (Editorial) Adv Physiol
13. Mary Shimoyama, G. Thomas Hayman, Stanley J. F. Laulederkind, Rajni Nigam,
Timothy F. Lowry, Victoria Petri, Jennifer R. Smith, Shur-Jen Wang, Diane H. Munzenmaier, Melinda R. Dwinell, Simon N. Twigger, Howard J. Jacob, the RGD Team. The Rat Genome Database Curators: Who, What, Where, Why. PLoS Comput Biol. 2009; 5(11). Books, Chapters, & Reviews:
1. Harder, D.R., Roman, R.J., Koehler, R.C., Alkayed, N., Gebremedhin, D.,
Munzenmaier, D.H., Medhora, M.M., Narayanan, J. Hyperpolarizing Factors and Membrane Potential in Cerebral Arterioles: A Role for Astrocytes and Cytochrome P450 Genes. In: Vanhoutte, P.M., ed. EDHF. London and New York: Taylor & Francis, 1998. Abstracts: 1. Held-Munzenmaier, D., G.N. Olinger, and L.E. Boerboom. A sheath for repetitive insertion of high-fidelity micromanometer-tipped catheters. FASEB J 3:A1174, 1989. 2. McManus, R.P., Kinney, T.E., Komorowski, R.A., Hanson, G.A., Munzenmaier, D.H., Strandt, J., Kneeland, J.B., Li, S-J. Characteristics of cardiac primate xenograft rejection and resolution studied by histology and in vivo 31p spectroscopy. Society of Magnetic Resonance in Medicine, 1989. 3. Munzenmaier, D.H. and A.S. Greene. Angiotensin II stimulation of vascular smooth muscle cells causes a sustained increase in nuclear calcium. FASEB J 7:A315, 1993. 4. Munzenmaier, D.H. and A.S. Greene. Stimulation of soluble guanylate cyclase activity by angiotensin II is mediated by a non-AT1 receptor mechanism in rat aorta. FASEB J 8:A367, 1994. 5. Munzenmaier, D.H. and A.S. Greene. Angiotensin II stimulation of vascular smooth muscle cells causes a sustained rise in calcium through multiple pathways. FASEB J 8:A1052, 1994. 6. Munzenmaier, D.H. and A.S. Greene. Opposing effects of angiotensin II receptor subtypes in the control of microvascular density. FASEB J 9:A588, 1995. 7. Munzenmaier, D.H. and A.S. Greene. Angiotensin II receptor subtypes mediate opposing actions in the control of blood pressure and vascular tone. Hypertension1995. 8. Munzenmaier, D.H. and D.R. Harder. Angiotensin II increases expression of a cytochrome P-450 4A-like protein in vascular smooth muscle. FASEB J 10:A147, 1996. 9. Nora, E.H., Munzenmaier, D.H., Greene, A.S. Regulation of angiotensin II receptors in cremasteric microvessels by sodium intake. FASEB J 10:A58, 1996. 10. Greene, A.S., Rieder, M.J., Munzenmaier, D.H., Cooke, A.R., Hansen-Smith, F.M., Lombard, J.H. Microvascular remodeling in renal hypertension: forces to be reckoned with. Ann Biomed Engin24:S-34,1996. 11. Munzenmaier, D.H., Harder, D.R. Role of astrocytes in cerebral angiogenesis. FASEB J 11:A64, 1997.
12. Munzenmaier, D.H., Harder, D.R. Regulation of astrocytic adhesion to extracellular matrix proteins and expression of integrin subunits β4 and β1 by hypoxia. FASEB J12:A38, 1998. 13. Munzenmaier, D.H., Greene, A.S. Alterations in laminin deposition and cellular adhesion in astrocytes and endothelial cells following hypoxia. FASEB J14:A10, 2000. 14. Munzenmaier, D.H., Greene, A.S. Cerebral microvascular endothelial cell and astrocyte migration stimulated by extracellular matrix proteins. FASEB J15:A31, 2001. 15. Munzenmaier, D.H., Greene, A.S. Differential roles of VEGF and angiotensin II in cerebral angiogenesis under hypoxic or normoxic conditions. FASEB J16:A516, 2002. 16. Munzenmaier, D.H., Greene, A.S. Cerebral vessel density alterations following oral losartan administration. Hypertension40:439, 2002. 17. Munzenmaier, D.H., Greene, A.S. Short-term angiotensin II (ANG II) receptor blockade induces cerebral angiogenesis. FASEB J 17:A553, 2003. 18. Forder, J.F., Greene, A.S., Munzenmaier, D.H. Focal ischemia model of stroke in rat. FASEB J 17:A895, 2003. 19. Munzenmaier D.H., Greene, A.S. Angiotensin II receptor blockade increases cerebral microvessel density in rats. J Cereb Blood Flow Metab 23:490, 2003. 20. Forder, J.P., Greene, A.S., Munzenmaier, D.H., Sengupta, J. Remodeling of the rat whisker barrel cortex following focal ischemia. Program No. 737.17. Washington, DC: Society for Neuroscience, 2003. 21. Forder, J.F., Munzenmaier, D.H., Greene, A.S. Angiotensin receptor blockade protects against cerebral ischemia in the rat. FASEB J 18:A1012, 2004. 22. Munzenmaier, D.H., Greene, A.S. Angiotensin II (Ang II) receptor blockade induces cerebral angiogenesis in a pressure-independent manner. FASEB J 18:A256, 2004. 23. Forder, J.F., Munzenmaier, D.H., Camara, A.K.S., Greene, A.S. ICV infusion of AT1 antagonist indicates angiogenic protection against permanent focal ischemia in the rat. FASEB J 19:A, 2005. 24. Munzenmaier, D.H., Greene, A.S. Oral losartan administration induces cerebral angiogenesis by specific AT1 receptor blockade. FASEB J 19:A, 2005. 25. Stingley, C., Munzenmaier, D.H. Brain microvascular endothelial cell proliferation with angiotensin stimulation and receptor blockade. FASEB J 20:A, 2006. 26. Munzenmaier, D.H., Greene, A.S. Stimulation of cerebral and dermal microvascular endothelial cell proliferation by AT1 receptor antagonist losartan. FASEB 21:A, 2007. 27. Munzenmaier, D.H., Greene, A.S. Angiotensin receptor blocker treatment causes paradoxical microvascular endothelial cell proliferation. FASEB 22:A, 2008. 28. Dwinell, M., Shimoyama, M., Nigam, R., DePons J., Munzenmaier, D., Twigger, S., Jacob, H. Phenotypes and Models portal at RGD: Providing an entrée to genomics for physiologists. Cold Spring Harbor Rat Genomics and Models, Hinxton, UK, December 2008. 29. Kwitek, A., Davis, S., Shimoyama, M., Hu, Z., Munzenmaier, D., Dwinell, M., Reecy, J.M. VCMap, v.2: A cross-species, integrated annotation platform. Cold Spring Harbor Rat Genomics and Models, Hinxton, UK, December 2008. 30. Shimoyama, M., Nigam, R., Smith, J., Stoddard, A., Munzenmaier, D., Twigger, S., Dwinell, M., Jacob, H. Phenotypes at RGD: New tools for integrating and mining complex phenotype data. Cold Spring Harbor Rat Genomics and Models, Hinxton, UK, December 2008. 31. Smith, J., Shimoyama, M., Worthey, L., Stoddard, A., DePons J., Bakir, B., Petri, V., Laulederkind, S., Nigam, R., Lowry, T., Munzenmaier, D., Patzer, A., Twigger, S., Dwinell, M., Jacob, H. Enhanced navigation of RGD data and tools. Cold Spring Harbor Rat Genomics and Models, Hinxton, UK, December 2008.
32. Twigger, S., DePons J., Abraham, D., Shimoyama, M., Dwinell, M., Munzenmaier, D., Jacob, H., and the Rat Genome Database Team. RGD Education and Outreach in the YouTube Era. Cold Spring Harbor Rat Genomics and Models, Hinxton, UK, December 2008. 33. Munzenmaier, D.H., Dwinell, M., Petri, V., Shimoyama, M., Jacob, H. The Physiological Pathways Portal: a new interactive online tool providing efficient access to genomic and phenomic information through biological pathway analysis. FASEB J. 2009. 34. Munzenmaier, D.H., Dwinell, M., Nigam, R., Shimoyama, M., Jacob, H. The Phenotypes and Models Portal: a new interactive online tool for physiologists linking genotype to phenotype and disease. FASEB J. 2009. 35. Munzenmaier, D.H., Worthey, E.A., Jacob, H.J. An interactive, clinical case study, computer module for teaching medical genetics using genomic sequence analysis tools. FASEB J. 2009. 36. Park, C., Hu, Z., Dwinell, M., Shimoyama, M., Munzenmaier, D., Davis, S., Kwitek, A., Reecy, J. Development of bioinformatic resources to transfer biological information across species. Plant & Animal Genome XVII, 2009. 37. Munzenmaier, D.H., Dwinell, M., Petri, V., Shimoyama, M., Jacob, H.J. Physiological pathway diagrams at RGD: A new, interactive, online tool providing efficient access to genotype and phenotype data through biological pathway analysis. Rat Genomics & Models, Cold Spring Harbor Laboratory, 2009. 38-46. Co-authored additional RGD team abstracts (9). Rat Genomics & Models, Cold Spring Harbor Laboratory, 2009.
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