Microsoft word - munzenmaier dhm curriculum vitae.doc

Diane H. Munzenmaier, Ph.D.
Office Address:
Place of Birth:

4. Citizenship: U.S.A.
5. Education:

Postgraduate Training:

05/1995 – 06/1999
Postdoctoral Fellow Medical College of Wisconsin Cardiovascular Research Center Milwaukee, WI
7.
Faculty Appointments:

07/2009 – present
Education Coordinator
Human and Molecular Genetics Center
Assistant Professor of Physiology Human and Molecular Genetics Center 8. Awards and Honors:
Caroline tum Suden Professional Opportunity Award Caroline tum Suden/Francis A. Hellebrandt Award Merck Young Investigator Award for Excellence in American Heart Association High Blood Pressure Council Memberships in Professional and Honorary Societies:
American Heart Association - Stroke Council American Physiological Society Microcirculatory Society Wisconsin Association for Biomedical Research and Education Editorial Peer Reviewer:
Advances in Physiology Education
American Journal of Physiology: Comparative and Regulatory Physiology
American Journal of Physiology: Heart and Circulatory Physiology
Circulation
Circulation Research
European Journal of Neurology
Hypertension
Kidney International
Microcirculation
Physiological Genomics
National Elected/Appointed Leadership and Committee Positions:
04/2007 Reviewer, NIAID-funded Center for Medical Countermeasures
against Radiological Terrorism (CMCRT) Pilot Research Grants Program Reviewer, NIH Study Section, SBIR/STTR Special Emphasis
Panel, Cardiovascular Sciences Small Business Activities
Judge, David S. Bruce Undergraduate Research Award,
American Physiological Society Education Committee.
Voted on 12 finalists to present research at Experimental Biology
meeting. Part of a committee that judged final presentations and
chose four award winners.

Member, Steering Committee for the 8th World Congress for
Microcirculation to be held in Milwaukee, August 2007.
6/2004 – 08/2007 Chair, Social Subcommittee for the 8th World Congress for
Microcirculation to be held in Milwaukee, August 2007. Member, Facilities Subcommittee for the 8th World Congress for
Microcirculation to be held in Milwaukee, August 2007.
Chair, Subcommittee for the development of “Physiology
Understanding Week” (“PhUn Week”), American Physiological
Society Education Committee.
Submitted proposal to APS Council for development of a $10,000
pilot program to encourage K-12 outreach by APS members which
was tested Nov 2005. Expansion of program to entire APS
membership has been approved by APS council and is currently
being further developed and tested.
http://www.the-aps.org/education/PhUnWeek.htm
Member, Education Committee, American Physiological Society
Research Grants, Contracts, Awards, Projects:
Peer Review
A. Active
Title: Rat Genome Database
Title: Intracellular Mechanisms of the Effects of Angiotensin II on Blood Vessel Growth Source: American Heart Association Predoctoral Fellowship, #93-F-Pre-12 Title: The Role of Angiotensin II Subtypes in Angiogenesis of the Microcirculation Source: American Heart Association Predoctoral Fellowship, #94-Pre-10 Source: NIH National Research Service Award, #1 T32 HL007792-01 Title: Differential Regulation of Angiotensin II Receptor Subtypes as a Consequence of Source: American Heart Association Postdoctoral Fellowship, #95-Post-29 6 4 Integrins in Hypoxia-induced Cerebral Angiogenesis Source: American Heart Association Scientist Development Award, #9930342A Title: Frontiers in Physiology Professional Opportunity Award Role: Mentor to Cecilia Stingley, high school teacher Title: Blood Pressure – Determinants and Controllers (Cowley) Project 5: Sodium Intake and ANG II in Microvascular Rarefaction Title: National Heart, Lung, Blood Institute Proteomics Initiative (Greene)
C. Pending
Title: Translational genetics of diabetes, obesity, and the metabolic syndrome
Invited lectures/Workshops/Presentations/Site Visits:
International
Platform presenter
“Angiotensin II Receptor Blockade Increases Cerebral Microvessel Density in Rats.”
XXIst International Symposium on Cerebral Blood Flow and Metabolism Workshop contributor
Rat Genome Database Blood Pressure Regulation Ontology Development Medical College of Wisconsin, June 25-26, 2008.
Platform presenter
“An interactive, clinical case study, computer module for teaching medical genetics using
genomic sequence analysis tools.” Experimental Biology, New Orleans, 2009.
Regional
Invited speaker
“Angiotensin: Regulation and Function in the Cardiovascular System”
Midwest Physiology Society Symposium
Medical College of Wisconsin, Feb. 15, 1995
Invited speaker
“Medical School Admissions at MCW”
Summer Program for Undergraduate Research (SPUR) Seminar Series
Medical College of Wisconsin, Summers 2004-06

14.
Medical College of Wisconsin Committees/Service:
07/2009 – 06/2010
Graduate Studies Council Awards Committee, Chair
Organized judging of ~70 graduate student posters for 1st Annual “Research Day” event, 9/16/09. Responsible for travel award and dissertation award judging. Institutional Animal Care and Use Committee, Alternate
Member – same responsibilities as Scientist Member (below),
fewer required review meetings.
Institutional Animal Care and Use Committee, Scientist
Member - responsible for semi-annual program evaluation as well
as review and approval of animal use research proposals as well as
numerous other responsibilities.
Medical Scientist Training Program (MSTP) Interviewer –
Conduct interviews with MSTP applicants and evaluate their
suitability for the program.
Graduate Studies Council Awards Committee – Judge presentations
and choose award winners at the annual graduate student poster
session and for travel award winners throughout the year.
Junior Faculty representative at LCME site visit – Met with site
visit examiners to answer questions regarding the experience of
young faculty members at MCW and the role of MCW in faculty
development.
Bioengineering and Biotechnology Center Business Manager
Search Committee – Interviewed 18 pre-screened applicants for
Position and made recommendations on suitability for hire.
Medical School Admissions Screening Subcommittee –
Involved in setting new guidelines for screening of applications in
order to enhance the ability of the committee to improve the
quality and diversity of the medical school class.
LCME Subcommittee on Graduate Education in the Basic
Sciences and Research – Selected to help develop the report that was
submitted for the Liaison Committee for Medical Education (LCME)
accreditation review.
Medical School Admissions Committee - Involved in
interviewing medical school applicants throughout the school year
and making decisions regarding their potential for admission to the
upcoming class. Elected to 2nd term in 2004. Elected to “Extended
Service” position in 2007.
Summer Program for Undergraduate Research (SPUR)
presentation judge – Help to evaluate oral presentations of
undergraduate students who had spent the summer doing research in
an MCW laboratory.
Department of Physiology Committees/Service:
03/2000 – present
Physiology Graduate School Admissions Committee
Involved in interviewing physiology graduate school applicants
each spring and making decisions regarding their potential for
admission to the upcoming class.
Departmental Website committee
Developed plan and worked closely with website developers to create an updated departmental website initially released 10/2005. Director, departmental cell culture core lab
Oversees lab and trains users of facility. Medical College of Wisconsin Teaching Activities:
Medical Student Education
“Medical Physiology Laboratory”
“Using Genomic Sequence in Diagnosis” Developed new
laboraotryaught lab to first year medical students 03/2009.
Undergoing further development for 2010.
“Medical Physiology Laboratory” development
Medical College of Wisconsin
Department of Physiology
“Using Genomic Sequence in Diagnosis”
“Medical Physiology Laboratory” author/director
Medical College of Wisconsin Department of Physiology “Assessment and Analysis of Cardiovascular Function in the Pig” “Medical Physiology Laboratory” instructor
Medical College of Wisconsin Department of Physiology
02/2002 – 02/2007 “Neuroscience” course lecturer
Medical College of Wisconsin Department of Cellular Biology, Neurobiology, and Anatomy “Regulation of the Extracellular Environment in the CNS” “Medical Physiology” course lecturer
Medical College of Wisconsin Department of Physiology “Cardiovascular Techniques” “Medical Physiology” course lecturer
Medical College of Wisconsin Department of Physiology Graduate Medical Education
08/2009 – present
Residency Program Coordinator
Development of new Clinical Genetics Residency with Pediatrics-
Genetics to be submitted to ACGME for accreditation, July, 2010.

Graduate Student Education
01/2010-05/2010
“Translational Genetics” course director and lecturer
New requisite course for M.S. program in Clinical and Translational
Science, CTSI
12/2009 “Endocrine Regulation” lecturer
Medical College of Wisconsin Department of Physiology, Second year Ph.D. student course “Advanced Systems Physiology” lecturer/block director
Medical College of Wisconsin Department of Physiology, Second year Ph.D. student course “Physiology of Aging” (PUBS 287)
Undergraduate Education
01/1999 – 05/1999
“Neurobiology” lecturer (BIOL 155)
Marquette University Biology Department, Milwaukee, WI Upper level course, full semester, 38 lectures Community/Lay Public Education
11/2008
Presenter, Physiology Understanding (PhUn) Week
Exercise Physiology course (50 high school upperclassmen) Presenter, Physiology Understanding (PhUn) Week
Pilgrim Park Middle School, Elm Grove, WI 8th grade (total of 300 students) Physiology Course instructor
Biology Item Writer
MCW Students, Faculty, Residents, or Fellows Mentored:
06/2000 – 08/2000
Summer research mentor
Marques’ Williams, Milwaukee Technical High School
Project SEED, minority mentoring program, American Chemical
Society
Frontiers in Physiology Mentor
Cecilia Stingley, high school science teacher Ph.D. dissertation committee member
Community Service Activities:
08/1990 – present
Member, Marquette University “M” Club
MU Athletics booster club comprised of former varsity athletes Vice-President/President-Elect, 1996-97 President, Member, Hall of Fame Selection Committee, 1999, 2006, 2009 Chair, Hall of Fame Selection Committee, 2011 induction Chair, “Family Science” event,
Special Judge
Science Fair Judge
Organizer, Turkey Trot Fun Run fundraiser for the Brookfield
East High School Spartan Athletics Booster Club.
Community Awards:
All-American at Marquette University (total of 5 awards
in Cross Country, Indoor & Outdoor Track).

09/1996 Inductee, Marquette University Athletics Hall of Fame
Member of 1982 National Champion Cross Country Team, Fifth place individual overall in national championship meet. Hy Popuch Memorial Award Winner
Awarded by the Marquette University “M” Club for service to the
“M” Club and to Marquette University athletics.

12/2010 Inductee, Athletics Hall of Fame
Bibliography
Refereed Journal Publications/Original Papers:
1. Held-Munzenmaier, D., Olinger, G.N., Boerboom, L.E. A sheath for repetitive
insertion of high-fidelity micromanometer-tipped catheters. Am J Physiol 257(Heart Circ Physiol): H1312-H1314, 1989. 2. Munzenmaier, D.H., Greene, A.S. Angiotensin II mediates a sustained rise in nuclear
and cytoplasmic calcium via multiple receptor subtypes. Am J Physiol 269 (Heart Circ Physiol):H565-H570, 1995. 3. Munzenmaier, D.H., Greene, A.S. Opposing actions of angiotensin II on microvascular
growth and arterial blood pressure. Hypertension 27[part 2]:760-65, 1996. 4. Nora, E.H., Munzenmaier D.H., F.M. Hansen-Smith, J.H. Lombard, and A.S. Greene.
Localization of the angiotensin II type 2 receptor in the microcirculation of skeletal muscle. Am J Physiol (Heart Circ Physiol) 44:H1395-1403, 1998. 5. Munzenmaier, D.H., Harder, D.R. Cerebral microvascular endothelial cell tube
formation: effect of blockade of astrocytic epoxyeicosatrienoic acid production. Am J Physiol (Heart Circ Physiol) 278:H1163-7, 2000. 6. Santos, C.F., Caprio, M.A.V., Oliviera, E.B., Salgado, M.C.O., Schippers, D.N., Munzenmaier, D.H., and A.S. Greene. Functional role, cellular source and tissue distribution
of rat elastase-2, an angiotensin II-forming enzyme. Am J Physiol (Heart Circ Physiol)
285:H775-83, 2003.
7. Forder J.P., Munzenmaier, D.H., Greene, A.S. Angiogenic protection from focal
ischemia with angiotensin II type 1 receptor blockade in the rat. Am J Physiol (Heart Circ Physiol), 288: H1989 - H1996, 2005. 8. Ardelt, A.A., McCullough, L.D., Korach, K.S., Wang, M.M., Munzenmaier, D.H.,
Hurn, P.D. Estradiol regulates angiopoietin-1 mRNA expression through estrogen receptor-α in a rodent experimental stroke model. Stroke 36:337-41, 2005. 9. Munzenmaier, D.H., Greene, A.S. Chronic angiotensin II AT1 receptor blockade
increases cerebral microvessel density. Am J Physiol (Heart Circ Physiol) 290: H512-H516, 2006. 10. Resende, M.M., Amaral, S.L., Munzenmaier, D.H., Greene, A.S. Role of endothelial
cell apoptosis in regulation of skeletal muscle angiogenesis during high and low salt intake. Physiol Genomics 25:325-35, 2006. 11. Petersen, M.C., Munzenmaier, D.H., Greene, A.S. Angiotensin II infusion restores
stimulated angiogenesis in the skeletal muscle of rats on a high-salt diet, Am J Physiol (Heart Circ Physiol) 291:114-20, 2006. 12. Munzenmaier, D.H. Help protect the future of physiology. (Editorial) Adv Physiol
13. Mary Shimoyama, G. Thomas Hayman, Stanley J. F. Laulederkind, Rajni Nigam, Timothy F. Lowry, Victoria Petri, Jennifer R. Smith, Shur-Jen Wang, Diane H. Munzenmaier,
Melinda R. Dwinell, Simon N. Twigger, Howard J. Jacob, the RGD Team. The Rat Genome
Database Curators: Who, What, Where, Why. PLoS Comput Biol. 2009; 5(11).

Books, Chapters, & Reviews:
1. Harder, D.R., Roman, R.J., Koehler, R.C., Alkayed, N., Gebremedhin, D., Munzenmaier, D.H., Medhora, M.M., Narayanan, J. Hyperpolarizing Factors and Membrane
Potential in Cerebral Arterioles: A Role for Astrocytes and Cytochrome P450 Genes. In:
Vanhoutte, P.M., ed. EDHF. London and New York: Taylor & Francis, 1998.
Abstracts:
1. Held-Munzenmaier, D., G.N. Olinger, and L.E. Boerboom. A sheath for repetitive
insertion of high-fidelity micromanometer-tipped catheters. FASEB J 3:A1174, 1989.
2. McManus, R.P., Kinney, T.E., Komorowski, R.A., Hanson, G.A., Munzenmaier, D.H.,
Strandt, J., Kneeland, J.B., Li, S-J. Characteristics of cardiac primate xenograft rejection and
resolution studied by histology and in vivo 31p spectroscopy. Society of Magnetic Resonance in
Medicine, 1989.
3. Munzenmaier, D.H. and A.S. Greene. Angiotensin II stimulation of vascular smooth
muscle cells causes a sustained increase in nuclear calcium. FASEB J 7:A315, 1993.
4. Munzenmaier, D.H. and A.S. Greene. Stimulation of soluble guanylate cyclase activity by
angiotensin II is mediated by a non-AT1 receptor mechanism in rat aorta. FASEB J 8:A367,
1994.
5. Munzenmaier, D.H. and A.S. Greene. Angiotensin II stimulation of vascular smooth
muscle cells causes a sustained rise in calcium through multiple pathways. FASEB J 8:A1052,
1994.
6. Munzenmaier, D.H. and A.S. Greene. Opposing effects of angiotensin II receptor subtypes
in the control of microvascular density. FASEB J 9:A588, 1995.
7. Munzenmaier, D.H. and A.S. Greene. Angiotensin II receptor subtypes mediate opposing
actions in the control of blood pressure and vascular tone. Hypertension 1995.
8. Munzenmaier, D.H. and D.R. Harder. Angiotensin II increases expression of a cytochrome
P-450 4A-like protein in vascular smooth muscle. FASEB J 10:A147, 1996.
9. Nora, E.H., Munzenmaier, D.H., Greene, A.S. Regulation of angiotensin II receptors in
cremasteric microvessels by sodium intake. FASEB J 10:A58, 1996.
10. Greene, A.S., Rieder, M.J., Munzenmaier, D.H., Cooke, A.R., Hansen-Smith, F.M.,
Lombard, J.H. Microvascular remodeling in renal hypertension: forces to be reckoned with.
Ann Biomed Engin 24:S-34,1996.
11. Munzenmaier, D.H., Harder, D.R. Role of astrocytes in cerebral angiogenesis. FASEB J
11:A64, 1997.
12. Munzenmaier, D.H., Harder, D.R. Regulation of astrocytic adhesion to extracellular
matrix proteins and expression of integrin subunits β4 and β1 by hypoxia. FASEB J 12:A38,
1998.
13. Munzenmaier, D.H., Greene, A.S. Alterations in laminin deposition and cellular adhesion
in astrocytes and endothelial cells following hypoxia. FASEB J 14:A10, 2000.
14. Munzenmaier, D.H., Greene, A.S. Cerebral microvascular endothelial cell and astrocyte
migration stimulated by extracellular matrix proteins. FASEB J 15:A31, 2001.
15. Munzenmaier, D.H., Greene, A.S. Differential roles of VEGF and angiotensin II in
cerebral angiogenesis under hypoxic or normoxic conditions. FASEB J 16:A516, 2002.
16. Munzenmaier, D.H., Greene, A.S. Cerebral vessel density alterations following oral
losartan administration. Hypertension 40:439, 2002.
17. Munzenmaier, D.H., Greene, A.S. Short-term angiotensin II (ANG II) receptor blockade
induces cerebral angiogenesis. FASEB J 17:A553, 2003.
18. Forder, J.F., Greene, A.S., Munzenmaier, D.H. Focal ischemia model of stroke in rat.
FASEB J 17:A895, 2003.
19. Munzenmaier D.H., Greene, A.S. Angiotensin II receptor blockade increases cerebral
microvessel density in rats. J Cereb Blood Flow Metab 23:490, 2003.
20. Forder, J.P., Greene, A.S., Munzenmaier, D.H., Sengupta, J. Remodeling of the rat
whisker barrel cortex following focal ischemia. Program No. 737.17. Washington, DC: Society
for Neuroscience, 2003.
21. Forder, J.F., Munzenmaier, D.H., Greene, A.S. Angiotensin receptor blockade protects
against cerebral ischemia in the rat. FASEB J 18:A1012, 2004.
22. Munzenmaier, D.H., Greene, A.S. Angiotensin II (Ang II) receptor blockade induces
cerebral angiogenesis in a pressure-independent manner. FASEB J 18:A256, 2004.
23. Forder, J.F., Munzenmaier, D.H., Camara, A.K.S., Greene, A.S. ICV infusion of AT1
antagonist indicates angiogenic protection against permanent focal ischemia in the rat. FASEB J
19:A, 2005.
24. Munzenmaier, D.H., Greene, A.S. Oral losartan administration induces cerebral
angiogenesis by specific AT1 receptor blockade. FASEB J 19:A, 2005.
25. Stingley, C., Munzenmaier, D.H. Brain microvascular endothelial cell proliferation with
angiotensin stimulation and receptor blockade. FASEB J 20:A, 2006.
26. Munzenmaier, D.H., Greene, A.S. Stimulation of cerebral and dermal microvascular
endothelial cell proliferation by AT1 receptor antagonist losartan. FASEB 21:A, 2007.
27. Munzenmaier, D.H., Greene, A.S. Angiotensin receptor blocker treatment causes
paradoxical microvascular endothelial cell proliferation. FASEB 22:A, 2008.
28. Dwinell, M., Shimoyama, M., Nigam, R., DePons J., Munzenmaier, D., Twigger, S., Jacob,
H. Phenotypes and Models portal at RGD: Providing an entrée to genomics for physiologists.
Cold Spring Harbor Rat Genomics and Models, Hinxton, UK, December 2008.
29. Kwitek, A., Davis, S., Shimoyama, M., Hu, Z., Munzenmaier, D., Dwinell, M., Reecy, J.M.
VCMap, v.2: A cross-species, integrated annotation platform. Cold Spring Harbor Rat
Genomics and Models, Hinxton, UK, December 2008.
30. Shimoyama, M., Nigam, R., Smith, J., Stoddard, A., Munzenmaier, D., Twigger, S.,
Dwinell, M., Jacob, H. Phenotypes at RGD: New tools for integrating and mining complex
phenotype data. Cold Spring Harbor Rat Genomics and Models, Hinxton, UK, December 2008.
31. Smith, J., Shimoyama, M., Worthey, L., Stoddard, A., DePons J., Bakir, B., Petri, V.,
Laulederkind, S., Nigam, R., Lowry, T., Munzenmaier, D., Patzer, A., Twigger, S., Dwinell,
M., Jacob, H. Enhanced navigation of RGD data and tools. Cold Spring Harbor Rat Genomics
and Models, Hinxton, UK, December 2008.
32. Twigger, S., DePons J., Abraham, D., Shimoyama, M., Dwinell, M., Munzenmaier, D.,
Jacob, H., and the Rat Genome Database Team. RGD Education and Outreach in the YouTube
Era. Cold Spring Harbor Rat Genomics and Models, Hinxton, UK, December 2008.
33. Munzenmaier, D.H., Dwinell, M., Petri, V., Shimoyama, M., Jacob, H. The Physiological
Pathways Portal: a new interactive online tool providing efficient access to genomic and
phenomic information through biological pathway analysis. FASEB J. 2009.
34. Munzenmaier, D.H., Dwinell, M., Nigam, R., Shimoyama, M., Jacob, H. The Phenotypes
and Models Portal: a new interactive online tool for physiologists linking genotype to phenotype
and disease. FASEB J. 2009.
35. Munzenmaier, D.H., Worthey, E.A., Jacob, H.J. An interactive, clinical case study,
computer module for teaching medical genetics using genomic sequence analysis tools. FASEB
J. 2009.
36. Park, C., Hu, Z., Dwinell, M., Shimoyama, M., Munzenmaier, D., Davis, S., Kwitek, A.,
Reecy, J. Development of bioinformatic resources to transfer biological information across
species. Plant & Animal Genome XVII, 2009.
37. Munzenmaier, D.H., Dwinell, M., Petri, V., Shimoyama, M., Jacob, H.J. Physiological
pathway diagrams at RGD: A new, interactive, online tool providing efficient access to genotype
and phenotype data through biological pathway analysis. Rat Genomics & Models, Cold Spring
Harbor Laboratory, 2009.
38-46. Co-authored additional RGD team abstracts (9). Rat Genomics & Models, Cold Spring
Harbor Laboratory, 2009.

Source: http://www.hmgc.mcw.edu/faculty/cv/CV_Munzenmaier.pdf