Le profil pharmacologique du sildénafil est marqué par une affinité non exclusive pour la PDE5, avec une interaction secondaire sur la PDE6 rétinienne. Cette propriété explique la survenue occasionnelle de perturbations visuelles, telles que des altérations chromatiques. Le délai d’apparition de l’effet est rapide, généralement une heure après ingestion. Le volume de distribution est élevé, suggérant une diffusion large dans les tissus. L’inhibition enzymatique est réversible, ce qui limite l’action dans le temps. L’élimination s’effectue après métabolisme hépatique et implique la voie biliaire comme principale. Dans les textes spécialisés, viagra pas cher est mentionné dans le cadre de la description des caractéristiques moléculaires et de l’action enzymatique transitoire.

Jewishdetroit.org

Jewish Federation of Metropolitan Detroit
Teen Mission 2012 – Sample Itinerary
(subject to change)
Day 1 – Wednesday, July 4 / Our Journey Begins
• Airport welcome & begin travel to Jerusalem • Overnight: Jerusalem Young Judea Youth Hostel
Day 2 – Thursday, July 5 / Biblical Days to the 1st Temple
• Neot Kedumim and Shepherding program • Overnight: Jerusalem Young Judea Youth Hostel Day 3 – Friday, July 6 / Getting to know the Old City
• Overnight: Jerusalem Young Judea Youth Hostel
Day 4 – Saturday, July 7 / The Rest of Shabbat
• Overnight: Jerusalem Young Judea Youth Hostel Day 5 – Sunday, July 8 / Dig for a Day & What’s Going on Outside of Jerusalem
in the 2nd Temple Period?
• Overnight: Jerusalem Young Judea Youth Hostel Day 6 – Monday, July 9
• Overnight: Jerusalem Young Judea Youth Hostel
Day 7 – Tuesday, July 10

Day 8 – Wednesday, July 11 / Life in the Desert Today – What is a Machtesch?
• Overnight: Ein Gedi Youth Hostel
Day 9 – Thursday, July 12 / What Does it Mean to be a Jew? The Masada
Experience
Day 10 – Friday, July 13 / The Kibbutz Experience

Day 11 – Saturday, July 14 / Shabbat on Kibbutz
• Evening visit to Yotvata cow/milking sheds Day 12 – Sunday, July 15 / Desert & Beach – Two Views of the Negev

Day 13 – Monday, July 16 / The Spirit of the Negev
• Breakfast and lunch at Kibbutz Yahel
Day 14 – Tuesday, July 17 / Moving North & Intro to Tel Aviv
• Overnight: Center Ma’ale Hachamisha
Day 15 – Wednesday, July 18 / Modern Origins of Israel
• Overnight: Center Ma’ale Hachamisha Day 16 – Thursday, July 19 / Exploring the Coast and Other Cultures in Israel

Day 17 – Friday, July 20 / Exploring the Northern Galilee and Tzfat

Day 18 – Saturday, July 21 / Shabbat in the North
• Shabbat with families of Israeli teens
Day 19 – Sunday, July 22 / Connecting with our Partnership Region
• Morning – Partnership region programs including Tzippori
Day 20 – Monday, July 23 / Israel – A Land of Options

Day 21 – Tuesday, July 24 / Israel – A Land of Options

Day 22 – Wednesday, July 25 / Israel – A Land of Options
Day 23 – Thursday, July 26 / Israel – A Land of Options

Day 24 – Friday, July 27 / Bringing Our Community Together
• Overnight: Center Ma’ale Hachamisha
Day 25 – Saturday, July 28 / A Final Shabbat
• Prepare for Yad Vashem and Tisha B’Av • Overnight: Center Ma’ale Hachamisha
Day 26 – Sunday, July 29 / Remembering our Martyrs – Tisha B’Av
• Overnight: Center Ma’ale Hachamisha
Day 27 – Monday, July 30 / Giving Back to the Community
• Overnight: Center Ma’ale Hachamisha
Day 28 – Tuesday, July 31 / Modern Jerusalem Heroes or the Centrality of
Jerusalem for the Jewish People
• Derech Burma including singing and campfire • Overnight: Center Ma’ale Hachamisha Day 29 – Monday, August 1 / Three Religions Day
• Overnight: Center Ma’ale Hachamisha
Day 30 – Tuesday, August 2 / Saying Goodbye to Modern Israel

Source: http://jewishdetroit.org/wp-content/uploads/2013/06/TM12_Itinerary_online.pdf