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Appendix A: LiterAture seArch strAtegy
OVerVieW
Interface
BIOSIS Previews <1985 to 2009 Week 21>; Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations <4 May 2009>; Ovid MEDLINE(R) <1950 to April Week 4 2009> * Note: Subject headings have been customized for each database. Monthly search updates began June 2009 and ran to [DATE].
English

syntAx guide
At the end of a phrase, searches the phrase as a subject heading At the end of a phrase, searches the phrase as a subject heading Truncation symbol, or wildcard: retrieves plural or variations of a word Indicates that the marked subject heading is a primary topic Truncation symbol for one or no characters only Requires words are adjacent to each other (in any order) Adjacency within # number of words (in any order) Heading Word; usually includes subject headings and controlled vocabulary MedLine / BiOsis
Line # Searches
((Antidiabetic or anti diabetic or antihyperglycemic or anti-hyperglycemic or oral hypoglycemic or anti-diabetes or antidiabetes) adj (agent or agents or drug or drugs or compound or compounds)).ti,ab. (glitazone* or thiazolidinedione* or pioglitazone* or rosiglitazone* or actos or avandia or avandamet or avandaryl).ti,ab. (Sitagliptin or januvia or Vildagliptin or galvus or gliptin or incretin agent* or Exenatide or byetta or Liraglutide or victoza).ti,ab.
(486460-32-6 or 274901-16-5 or 141758-74-9 or 204656-20-2).rn.
(Dipeptidyl-Peptidase adj IV adj inhibitor*).ti,ab.
Open Medicine 2012;6(2):62–74 Appendices —1 dipeptidyl peptidase-4 inhibitors.ti,ab.
(sulfonylurea* or tolbutamide or Orinase or glyconon or tolazamide or Tolinase or chlorpropamide or Diabinese or glymese or glipizide or Glucotrol or glyburide or glibenclamide or glybenclamide or Diabeta or Micronase or Glynase or gen-glybe or euglucon or glimepiride or Amaryl or gliclazide or Diamicron or diaglyk or glibenese or minodiab or gen-gliclazide).ti,ab.
(64-77-7 or 1156-19-0 or 94-20-2 or 29094-61-9 or 10238-21-8 or 93479-97-1 or 21187-98-4).rn.
alpha-Glucosidases/ai [Antagonists & Inhibitors] (acarbose or glucobay or precose or prandase or akarbose or miglitol* or glyset or diastabol or voglibose).ti,ab.
(56180-94-0 or 72432-03-2 or 83480-29-9).rn.
((alph* adj glucos* adj inhibit*) or (alf* adj glucos* adj inhibit*)).ti,ab.
(random* or sham or placebo*).ti,ab,hw.
((singl* or doubl*) adj (blind* or dumm* or mask*)).ti,ab,hw.
(Orlistat or Xenical or Tetrahydrolipstatin or Sibutramine or meridia).ti,ab.
((tripl* or trebl*) adj (blind* or dumm* or mask*)).ti,ab,hw.
(repaglinide or nateglinide or Meglitinide* or prandin or gluconorm or starlix or novonorm).ti,ab.
(dimethylguanylguanidine or dimethylbiguanidine or glucophage).ti,ab.
(Glycon or Fortamet or Riomet or Venez or Diaformina or Dimefor or Glafornil or Glucaminol or Glucofage or Diabex or Diaformin or Glucohexal or Glucomet or Novomet or Metomin or Glucamet or Metsol or Orabet).ti,ab.
(apo-metformin or apotex or genmetformin or glucophage or glumetza or novo-metformin or nu-metformin or pms-metformin or ran- metformin or ratio-metformin or rhoxal-metformin or sandoz metformin).ti,ab.
(long acting insulin* or long acting analog* or slow* acting insulin* or slow* acting analog*).ti,ab.
(Aron or Diabetosan or Diabex or Diformin or Diformin Retard or Dimethylbiguanide or Dmgg or Fluamine or Fortamet or Gliguanid or Glucoformin or Haurymellin or La 6023 or La6023 or Meguan or Mellittin or Metaformin or Methformin or Metiguanide or Metphormin or (glargine or Lantus or Optisulin or hoe 901 or 160337-95-1).ti,ab,rn.
Dimethylguanylguanide or Nndg or Dimethylbiguanide or Dimethyl Biguanidine or Dimethylbiguanidine or Dimethyldiguanide).ti,ab.
(detemir or determir or Levemir or nn 304 or 169148-63-4).ti,ab,rn.
(nph insulin or humulin or novolin).ti,ab.
(short acting insulin* or quick acting insulin* or rapid acting insulin* or rapidly acting insulin* or fast acting insulin* or quick acting analog* or rapid acting analog* or rapidly acting analog* or short acting analog* or fast acting analog*).ti,ab.
(Lispro or Lyspro or Humalog or Liprolog or 133107-64-9).ti,ab,rn.
(Insulin Aspart or 116094-23-6 or NovoLog or NovoRapid or NovoMix).ti,ab,rn.
(Glulisine or 207748-29-6 or Apidra).ti,ab,rn.
Line # Searches
((adult or ketosis-resistant or matur* or late or non-insulin depend* or noninsulin depend* or slow or stable or type 2 or type II or lipoatrophic) adj3 diabet$).ti,ab.
*Non Insulin Dependent Diabetes Mellitus/ ((adult or ketosis-resistant or matur* or late or non-insulin depend* or noninsulin depend* or slow or stable or type 2 or type II or lipoatrophic) adj3 diabet$).ti,ab.
(dimethylguanylguanidine or dimethylbiguanidine or glucophage).ti,ab.
Open Medicine 2012;6(2):62–74 Appendices —2 Open Medicine 2012;6(2):62–74 Appendices —3 (apo-metformin or apotex or genmetformin or glucophage or glumetza or novo-metformin or nu-metformin or pms-metformin or ran-metformin or ratio-metformin or rhoxal-metformin or sandoz metformin).ti,ab.
(Glycon or Fortamet or Riomet or Venez or Diaformina or Dimefor or Glafornil or Glucaminol or Glucofage or Diabex or Diaformin or Glucohexal *biphasic insulin/ or *human insulin/ or *insulin/ or *insulin aspart/ or *insulin detemir/ or *insulin glargine/ or *insulin glulisine/ or *insulin or Glucomet or Novomet or Metomin or Glucamet or Metsol or Orabet).ti,ab.
lispro/ or *isophane insulin/ or *long acting insulin/ or *monocomponent insulin/ or *neutral insulin/ or *recombinant human insulin/ or (Aron or Diabetosan or Diabex or Diformin or Diformin Retard or Dimethylbiguanide or Dmgg or Fluamine or Fortamet or Gliguanid or Glucoformin or Haurymellin or La 6023 or La6023 or Meguan or Mellittin or Metaformin or Methformin or Metiguanide or Metphormin or Dimethylguanylguanide or Nndg or Dimethylbiguanide or Dimethyl Biguanidine or Dimethylbiguanidine or Dimethyldiguanide).ti,ab.
(long acting insulin* or long acting analog* or slow* acting insulin* or slow* acting analog*).ti,ab.
(glargine or Lantus or Optisulin or hoe 901 or 160337-95-1).ti,ab,rn.
(detemir or determir or Levemir or nn 304 or 169148-63-4).ti,ab,rn.
(nph insulin or humulin or novolin).ti,ab.
((Antidiabetic or anti diabetic or antihyperglycemic or anti-hyperglycemic or oral hypoglycemic or anti-diabetes or antidiabetes) adj (agent or agents or drug or drugs or compound or compounds)).ti,ab.
(short acting insulin* or quick acting insulin* or rapid acting insulin* or rapidly acting insulin* or fast acting insulin* or quick acting analog* or rapid acting analog* or rapidly acting analog* or short acting analog* or fast acting analog*).ti,ab.
(glitazone* or thiazolidinedione* or pioglitazone or rosiglitazone or actos or avandia or avandamet or avandaryl).ti,ab.
(Lispro or Lyspro or Humalog or Liprolog or 133107-64-9).ti,ab,rn.
(Insulin Aspart or 116094-23-6 or NovoLog or NovoRapid or NovoMix).ti,ab,rn.
(Sitagliptin or januvia or Vildagliptin or galvus or gliptin or incretin agent* or Exenatide or byetta or Liraglutide or victoza).ti,ab.
(Glulisine or 207748-29-6 or Apidra).ti,ab,rn.
(486460-32-6 or 274901-16-5 or 141758-74-9 or 204656-20-2).rn.
(Dipeptidyl-Peptidase adj IV adj inhibitor*).ti,ab.
dipeptidyl peptidase-4 inhibitors.ti,ab.
(sulfonylurea* or tolbutamide or Orinase or glyconon or tolazamide or Tolinase or chlorpropamide or Diabinese or glymese or glipizide or Glucotrol or glyburide or glibenclamide or glybenclamide or Diabeta or Micronase or Glynase or gen-glybe or euglucon or glimepiride or Amaryl or gliclazide or Diamicron or diaglyk or glibenese or minodiab or gen-gliclazide).ti,ab.
(64-77-7 or 1156-19-0 or 94-20-2 or 29094-61-9 or 10238-21-8 or 93479-97-1 or 21187-98-4).rn.
(acarbose or glucobay or precose or prandase or akarbose or miglitol* or glyset or diastabol or voglibose).ti,ab.
(56180-94-0 or 72432-03-2 or 83480-29-9).rn.
((alph* adj glucos* adj inhibit*) or (alf* adj glucos* adj inhibit*)).ti,ab.
(Orlistat or Xenical or Tetrahydrolipstatin or Sibutramine or meridia).ti,ab.
(random* or sham or placebo*).ti,ab,hw.
((singl* or doubl*) adj (blind* or dumm* or mask*)).ti,ab,hw.
((tripl* or trebl*) adj (blind* or dumm* or mask*)).ti,ab,hw.
(repaglinide or nateglinide or Meglitinide* or prandin or gluconorm or starlix or novonorm).ti,ab.
Open Medicine 2012;6(2):62–74 Appendices —4 Open Medicine 2012;6(2):62–74 Appendices —5 cOchrAne centrAL register Of cOntrOLLed triALs
Line # Searches
(Lispro or Lyspro or Humalog or Liprolog or 133107-64-9).ti,ab,rn.
(Insulin Aspart or 116094-23-6 or NovoLog or NovoRapid or NovoMix).ti,ab,rn.
((Antidiabetic or anti diabetic or antihyperglycemic or anti-hyperglycemic or oral hypoglycemic or anti-diabetes or antidiabetes) adj (agent or (Glulisine or 207748-29-6 or Apidra).ti,ab,rn.
agents or drug or drugs or compound or compounds)).ti,ab.
((adult or ketosis-resistant or matur* or late or non-insulin depend* or noninsulin depend* or slow or stable or type 2 or type II or lipoatrophic) (glitazone* or thiazolidinedione* or pioglitazone* or rosiglitazone* or actos or avandia or avandamet or avandaryl).ti,ab.
(Sitagliptin or januvia or Vildagliptin or galvus or gliptin or incretin agent* or Exenatide or byetta or Liraglutide or victoza).ti,ab.
[(486460-32-6 or 274901-16-5 or 141758-74-9 or 204656-20-2).rn.] (Dipeptidyl-Peptidase adj IV adj inhibitor*).ti,ab.
(dimethylguanylguanidine or dimethylbiguanidine or glucophage).ti,ab.
dipeptidyl peptidase-4 inhibitors.ti,ab.
(apo-metformin or apotex or genmetformin or glucophage or glumetza or novo-metformin or nu-metformin or pms-metformin or ran-metformin or ratio-metformin or rhoxal-metformin or sandoz metformin).ti,ab.
(Glycon or Fortamet or Riomet or Venez or Diaformina or Dimefor or Glafornil or Glucaminol or Glucofage or Diabex or Diaformin or Glucohexal (sulfonylurea* or tolbutamide or Orinase or glyconon or tolazamide or Tolinase or chlorpropamide or Diabinese or glymese or glipizide or or Glucomet or Novomet or Metomin or Glucamet or Metsol or Orabet).ti,ab.
Glucotrol or glyburide or glibenclamide or glybenclamide or Diabeta or Micronase or Glynase or gen-glybe or euglucon or glimepiride or Amaryl or gliclazide or Diamicron or diaglyk or glibenese or minodiab or gen-gliclazide).ti,ab.
(Aron or Diabetosan or Diabex or Diformin or Diformin Retard or Dimethylbiguanide or Dmgg or Fluamine or Fortamet or Gliguanid or Glucoformin or Haurymellin or La 6023 or La6023 or Meguan or Mellittin or Metaformin or Methformin or Metiguanide or Metphormin or [(64-77-7 or 1156-19-0 or 94-20-2 or 29094-61-9 or 10238-21-8 or 93479-97-1 or 21187-98-4).rn.] Dimethylguanylguanide or Nndg or Dimethylbiguanide or Dimethyl Biguanidine or Dimethylbiguanidine or Dimethyldiguanide).ti,ab.
alpha-Glucosidases/ai [Antagonists & Inhibitors] (acarbose or glucobay or precose or prandase or akarbose or miglitol* or glyset or diastabol or voglibose).ti,ab.
[(56180-94-0 or 72432-03-2 or 83480-29-9).rn.] ((alph* adj glucos* adj inhibit*) or (alf* adj glucos* adj inhibit*)).ti,ab.
suppLeMentAL seArch, sAxAgLiptin
Orlistat or Xenical or Tetrahydrolipstatin or Sibutramine or meridia).ti,ab.
OVerVieW
(repaglinide or nateglinide or Meglitinide* or prandin or gluconorm or starlix or novonorm).ti,ab.
Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations <5 August 2009>; Ovid MEDLINE(R) <1950 to July Week 4 2009> * Note: Subject headings have been customized for each database. Monthly search updates ran to October 2009.
(long acting insulin* or long acting analog* or slow* acting insulin* or slow* acting analog*).ti,ab.
syntAx guide
(glargine or Lantus or Optisulin or hoe 901 or 160337-95-1).ti,ab,rn.
At the end of a phrase, searches the phrase as a subject heading (detemir or determir or Levemir or nn 304 or 169148-63-4).ti,ab,rn.
At the end of a phrase, searches the phrase as a subject heading (nph insulin or humulin or novolin).ti,ab.
(short acting insulin* or quick acting insulin* or rapid acting insulin* or rapidly acting insulin* or fast acting insulin* or quick acting analog* or Truncation symbol, or wildcard: retrieves plural or variations of a word rapid acting analog* or rapidly acting analog* or short acting analog* or fast acting analog*).ti,ab.
Indicates that the marked subject heading is a primary topic Open Medicine 2012;6(2):62–74 Appendices —6 Open Medicine 2012;6(2):62–74 Appendices —7 Truncation symbol for one or no characters only OrgAnizAtiOns And WeBsites seArched
Requires words are adjacent to each other (in any order) This section lists the main agencies, organizations and websites searched; it is not a complete list. Adjacency within # number of words (in any order) Agence d’Evaluation des Technologies et des Modes d’Intervention en Santé (AETMIS). Heading Word; usually includes subject headings and controlled vocabulary Agency for Healthcare Research and Quality (AHRQ) AHRQ Effective Health Care Program. Reports Canadian Agency for Drugs and Technologies in Health Line # Searches
(saxagliptin or onglyza or bms 477118 or bms-477118 or bms477118 or 3-hydroxyadamantylglycine-4,5-methanoprolinenitrile).ti,ab,rn.
(361442-04-811 or 945667-22-111).rn.
Clinical Trials Database (U.S. National Institutes of Health) limit 4 to (english language and yr=”1980 -Current”) Searches
Evidence Based Information on Prescription Drugs for Consumers and Health Care Providers (saxagliptin or onglyza or bms 477118 or bms-477118 or bms477118 or 3-hydroxyadamantylglycine-4,5-methanoprolinenitrile).ti,ab,rn.
(361442-04-811 or 94566g7-22-111).rn.
Institute for Clinical Evaluative Sciences (ICES). Ontario. cOchrAne centrAL register Of cOntrOLLed triALs
International Network for Agencies for Health Technology Assessment Searches
National Research Register. U.K. Dept. of Health. (saxagliptin or onglyza or bms 477118 or bms-477118 or bms477118 or 3-hydroxyadamantylglycine-4,5-methanoprolinenitrile).ti,ab,rn.
Ontario Ministry of Health and Long Term Care. Health Technology Reviews NPS RADAR (National Prescribing Service Ltd) NHS Health Technology Assessment /National Coordinating Centre for Health Technology Assessment (NCCHTA). Other dAtABAses
NHS National Institute for Clinical Excellence (NICE) Same MeSH, keywords, limits, and study types used as per MEDLINE search, with appropriate syntax used.
Same MeSH, keywords, and date limits used as per MEDLINE search, excluding study types. Syntax adjusted for Cochrane Library The Technology Assessment Unit of the McGill University Health Centre grey LiterAture And hAnd seArches
The Therapeutics Initiative. Evidence-Based Drug Therapy. University of BritishColumbia. metformin, second line therapy, oral anti diabetes agents, anti diabetic agents, type 2 diabetes. All keywords associated with each Veterans Affairs. Drug Class Reviews (U.S.) WHO – International Clinical Trials Registry Platform Search Portal Open Medicine 2012;6(2):62–74 Appendices —8 Open Medicine 2012;6(2):62–74 Appendices —9 conferences
societies/Organizations/Associations
American Association of Clinical Endocrinologists Annual Meeting and Clinical Congress (AACE) American Diabetes Association (ADA) Scientific Sessions Association of British Clinical Diabetologists European Association for the Study of Diabetes (EASD) European Society for Paediatric Endocrinology search engines
Open Medicine 2012;6(2):62–74 Appendices —10

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