Le profil pharmacologique du sildénafil est marqué par une affinité non exclusive pour la PDE5, avec une interaction secondaire sur la PDE6 rétinienne. Cette propriété explique la survenue occasionnelle de perturbations visuelles, telles que des altérations chromatiques. Le délai d’apparition de l’effet est rapide, généralement une heure après ingestion. Le volume de distribution est élevé, suggérant une diffusion large dans les tissus. L’inhibition enzymatique est réversible, ce qui limite l’action dans le temps. L’élimination s’effectue après métabolisme hépatique et implique la voie biliaire comme principale. Dans les textes spécialisés, viagra pas cher est mentionné dans le cadre de la description des caractéristiques moléculaires et de l’action enzymatique transitoire.

Microsoft word - publicationlistjuly2008ovds.doc

International refereed journals (first author)
van der Stelt, O., Gunning, W. B., Snel, J., Zeef, E., & Kok, A. (1994). Children of alcoholics: Attention, information processing and event-related brain potentials. Acta Paediatrica, 404 (Suppl.), 4-6. ISSN 0803-5326. van der Stelt, O. (1994). Caffeine and attention. Pharmacopsychoecologia, 7(2), 221-227. van der Stelt, O., Gunning, W. B., Snel, J., & Kok, A. (1997). No electrocortical evidence of automatic mismatch dysfunction in children of alcoholics. Alcoholism: Clinical and Experimental Research, 21, 569-575. ISSN 0145-6008. van der Stelt, O., Kok, A., Smulders, F. Y. T., Gunning, W. B., & Snel, J. (1998). Cerebral event-related potentials associated with selective attention to color: Developmental changes from childhood to adulthood. Psychophysiology, 35, 227-239. ISSN 0048-5772. van der Stelt, O., Geesken, R., Gunning, W. B., Snel, J., & Kok, A. (1998). P3 scalp topography to target and novel visual stimuli in children of alcoholics. Alcohol, 15 119-136. van der Stelt, O. (1998). The P3 component of the human event-related potential as a vulnerability marker of alcoholism. Alcohol Research, 3, 6-9 (Invited review). ISSN 1384- van der Stelt, O., Gunning, W. B., Snel, J., & Kok, A. (1998). Event-related potentials during visual selective attention in children of alcoholics. Alcoholism: Clinical and Experimental van der Stelt, O. (1999). Visual P3 as a potential vulnerability marker of alcoholism: Evidence from the Amsterdam study of children of alcoholics. Alcohol and Alcoholism, 34, 267-282 (Invited article, ESBRA-Nordmann 1998 Award Lecture). ISSN 0735-0414. van der Stelt, O., van der Molen, M., Gunning, W. B., & Kok, A. (2001). Neuroelectrical signs of selective attention to color in boys with attention-deficit hyperactivity disorder. Brain Research Cognitive Brain Research, 12 245-264. van der Stelt, O., Frye, J., Lieberman, J. A., & Belger, A. (2004). Impaired P3 generation reflects high-level and progressive neurocognitive dysfunction in schizophrenia. Archives of van der Stelt, O., Belger, A., & Lieberman, J. A. (2004). Macroscopic fast neuronal oscillations and synchrony in schizophrenia. Proceedings of the National Academy of Sciences of the United States of America, 101, 17567-17568. van der Stelt, O., Lieberman, J. A., & Belger, A. (2005). Auditory P300 in high-risk, recent- onset and chronic schizophrenia. Schizophrenia Research, 77, 309-320. van der Stelt, O., Lieberman, J. A., & Belger, A. (2006). Attentional modulation of early-stage visual processing in schizophrenia. Brain Research, 1125, 194-198. van der Stelt, O., & Belger, A. (2007). Application of electroencephalography to the study of cognitive and brain functions in schizophrenia. Schizophrenia Bulletin, 33, 955-970. Open Access article. Advance Access published on March 15, 2007. doi:10.1093/schbul/sbm016. van der Stelt, O. (2008). Development of human EEG posterior alpha rhythms. Clinical Neurophysiology, 119, 1701-1702. (Editorial). doi:10.1016/j.clinph.2008.04.001 van der Stelt, O., & van Boxtel, G.J.M. (in press, 2008). Auditory P300 and mismatch negativity in comatose states. Clinical Neurophysiology. (Editorial) International refereed journals (co-author)
Gunning, W. B., Pattiselanno, S. E., van der Stelt, O., & Wiers, R. W. (1994). Children of alcoholics: Predictors for psychopathology and addiction. Acta Paediatrica, 404 (Suppl.), 7-8. Ridderinkhof, K. J., & van der Stelt, O. (2000). Attention and selection in the growing child: Views derived from developmental psychophysiology. Biological Psychology, 54 55-106. Ratsma, J. E., van der Stelt, O., Schoffelmeer, A. N. M., Westerveld, A., & Gunning, W. B. (2001). Sensation seeking behavior, event-related potential P3 and dopamine D2 receptor A1 allele in adult children of alcoholics. Alcoholism: Clinical and Experimental Research, 25 Ratsma, J. E., van der Stelt, O., & Gunning, W. B. (2002). Neurochemical markers of alcoholism vulnerability in humans. Alcohol and Alcoholism, 37, 522-533. Dichter, G. S., van der Stelt, O., Laube, J., & Belger, A. (2006). Relations among intelligence, executive function, and P300 event-related potentials in schizophrenia. The Journal of Nervous and Mental Diseases, 194, 179-187. National refereed journals (first author)
van der Stelt, O. (1994). Is de P300 hersenpotentiaal een kwetsbaarheidsmarker voor alcoholisme? Tijdschrift voor Alcohol, Drugs en andere Psychotrope Stoffen, 20(4), 215-225 (with summary in English). ISSN 0378-2778. van der Stelt, O. (1998). Event-related potentials bij neuropsychiatrische aandoeningen en verslaving. Neuropraxis, 1, 16-23. ISSN 1387-5817.
Book chapters (first author)
van der Stelt, O. & Snel, J. (1993). Effects of caffeine on human information processing: A cognitive-energetic approach. In: S. Garattini (Ed.), Caffeine, Coffee and Health (Chapter 11, pp. 291-316). New York: Raven Press. ISBN 0-88167-961-5. van der Stelt, O. & Snel, J. (1998). Caffeine and human performance. In: J. Snel & M. Lorist (Eds.), Nicotine, Caffeine and Social Drinking. Behaviour and Brain Function (Chapter 7, pp. 167-184). Reading, UK: Harwood Academic Publishers. ISBN 90-5702-218-4. van der Stelt, O. (1999). Caffeine and attention. In: B. S. Gupta & U. Gupta (Eds.), Caffeine and Behavior: Current Views and Research Trends (Chapter 14, pp. 231-240). London: CRC
Book chapters (co-author)
Kok, A., Kenemans, J.L., Zeef, E.J., Lorist, M, Ridderinkhof, K.R., & van der Stelt, O. (1996). Selective processes in development and aging: Event-related potential studies. In: C. Ogura, Y. Koga, & M. Shimokochi (Eds.), Recent Advances in Event-Related Brain Potential Research (pp. 721-732). Amsterdam: Elsevier. ISBN 0-444-82280-1.
Book chapters issued in Dutch (first author)
van der Stelt, O. & Snel, J. (1996). Neurofysiologische aspekten. Het gebruik van metingen van opgeroepen hersenpotentialen in onderzoek naar kwetsbaarheid voor alcoholisme. In: M. J. A. J. M. Hoes en P. J. Geerlings (Eds.), Informatorium Alcoholisme (Chapter 10, pp. 1-5). Leusden: NZP Medical Publishing. ISBN 90-9009-239-0.

Source: http://webwijs.uvt.nl/publications/941712.pdf