Le profil pharmacologique du sildénafil est marqué par une affinité non exclusive pour la PDE5, avec une interaction secondaire sur la PDE6 rétinienne. Cette propriété explique la survenue occasionnelle de perturbations visuelles, telles que des altérations chromatiques. Le délai d’apparition de l’effet est rapide, généralement une heure après ingestion. Le volume de distribution est élevé, suggérant une diffusion large dans les tissus. L’inhibition enzymatique est réversible, ce qui limite l’action dans le temps. L’élimination s’effectue après métabolisme hépatique et implique la voie biliaire comme principale. Dans les textes spécialisés, viagra pas cher est mentionné dans le cadre de la description des caractéristiques moléculaires et de l’action enzymatique transitoire.

Www20.csueastbay.edu

CSUEB—Communicative Sciences & Disorders
Aging & Cognition Research Clinic
January 2008 Newsletter
Director
Nidhi Mahendra, Ph.D., CCC-SLP
Graduate Research Assistants
Allegra Apple, Danielle Reed,
Nisha Engineer, Susan Carroll
Ongoing Projects
x 
Studying the efficacy of computerized
cognitive interventions for older adults
with memory impairments
x 
Documenting effects of presentation modality
on episodic recall in young and old adults, as
well as those with dementia
Screening sensory and cognitive functions in
community-dwelling older adults
Investigating cultural and linguistic
barriers to accessing SLP services
Funding
x 
Alzheimer’s Association (2006-2009)
American Speech Language Hearing Association
(2006-2008)
Office of Research and Sponsored Programs—
CSUEB (2006-2007)
Currently Participating Sites
x 
Masonic Home for Adults—Union City
Email us at [email protected] OR
call us at (510) 885-3858
Some Recent Publications
(highlighted names-student authors)
Mahendra, N., Apple, A. (2007). Human memory systems: A
framework for understanding dementia. The ASHA Leader, 12
(16), 8-11
Mahendra, N., Arkin, S., Kim, E. (2007). Individuals with
Alzheimer’s disease achieve implicit and explicit learning:
Previous success replicated with different stimuli.
Aphasiology, 21(2), 187-207.
Zientz, J., Rackley, A., Chapman, S. B., Hopper, T.,
Mahendra, N., Kim, E., Cleary, S. (2007). Evidence-based
practice recommendations for dementia: Educating caregivers
on Alzheimer’s disease and training communication strate-
gies. Journal of Medical Speech Language Pathology, 15(1),
liii-lxiv.
Some Recent Presentations
(highlighted names-student authors)
Mahendra, N., Apple, A., Reed, D. (February 2008).
Computer-assisted training of face-name associations in
persons with dementia. Poster presentation, 2008
International Neuropsychological Society Meeting, Hawaii.
Battle, D. E., Payne, J. C., & Mahendra, N. (April 2007).
Using evidence to support cultural competence in adult
neurogenics. 2007 Annual Convention of the National Black
Association for Speech Language and Hearing (NBASLH),
Charlotte, North Carolina.
FORTHCOMING PROJECTS
Rate of learning information in persons with mild and
moderate dementia
x 
Reading speed and reading comprehension in persons with
dementia.

Source: http://www20.csueastbay.edu/class/departments/commsci/files/docs/acrc/ACRC-January-2008-newsletter.pdf