Dear doctor:

Dear Doctor:
Thank you for your interest in the enclosed reprint, “Efficacy and Safety of the Dipeptidyl Peptidase-4 Inhibitor, Sitagliptin,
in Patients With Type 2 Diabetes Mellitus Inadequately Controlled on Glimepiride Alone or on Glimepiride and Metformin"
by K. Hermansen et al, as published in Diabetes, Obesity and Metabolism, Volume 9, 2007. The objective of the study was
to examine the efficacy and safety of sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, in patients with type 2 diabetes
who had inadequate glycemic control (A1C ≥7.5% and ≤10.5%) while on glimepiride with or without metformin.
JANUVIA™ (sitagliptin) is indicated as an adjunct to diet and exercise to improve glycemic control in adult patients with
type 2 diabetes mellitus.
JANUVIA should not be used in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis. JANUVIA has
not been studied in combination with insulin.
JANUVIA is contraindicated in patients with a history of a serious hypersensitivity reaction to sitagliptin, such as
anaphylaxis and angioedema.
A dosage adjustment is recommended in patients with moderate or severe renal insufficiency or with end-stage renal disease
requiring hemodialysis or peritoneal dialysis.
As is typical with other antihyperglycemic agents used in combination with a sulfonylurea, when JANUVIA was used in
combination with a sulfonylurea, a class of medications known to cause hypoglycemia, the incidence of hypoglycemia was
increased over that of placebo. Therefore, a lower dose of sulfonylurea may be required to reduce the risk of hypoglycemia.
There have been postmarketing reports of serious hypersensitivity reactions in patients treated with JANUVIA. These
reactions include anaphylaxis, angioedema, and exfoliative skin conditions including Stevens-Johnson syndrome. Because
these reactions are reported voluntarily from a population of uncertain size, it is generally not possible to reliably estimate
their frequency or establish a causal relationship to drug exposure. Onset of these reactions occurred within the first
3 months after initiation of treatment with JANUVIA, with some reports occurring after the first dose. If a hypersensitivity
reaction is suspected, discontinue JANUVIA, assess for other potential causes for the event, and institute alternative
treatment for diabetes.
In clinical studies, the adverse reactions, regardless of investigator assessment of causality, in ≥5% of patients treated with
JANUVIA as monotherapy and in combination and more commonly than in patients treated with placebo, were upper
respiratory tract infection, nasopharyngitis, and headache.
In combination with sulfonylurea and with sulfonylurea and metformin, the adverse reaction of hypoglycemia was also
reported more commonly with JANUVIA than with placebo.
Before prescribing JANUVIA, please read the accompanying Prescribing Information. For additional copies of the
Prescribing Information, call 1-800-672-6372, visit, or contact your Merck representative.
Thank you for your interest in this information about JANUVIA.
Bram Greenberg, MD, FAAP Executive Director, Medical Services Enclosures: Prescribing Information for JANUVIA JANUVIA is a trademark of Merck & Co., Inc. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor,sitagliptin, in patients with type 2 diabetes mellitusinadequately controlled on glimepiride alone or on glimepirideand metformin K. Hermansen,1 M. Kipnes,2 E. Luo,3 D. Fanurik,3 H. Khatami3 and P. Stein,3for the Sitagliptin Study 035 Group* 1Aarhus University Hospital, Aarhus, Denmark2Diabetes and Glandular Disease Clinic, San Antonio, TX, USA3Merck Research Laboratories, Rahway, NJ, USA Aim: To assess the efficacy and safety of a 24 week treatment with sitagliptin, a highly selective once daily oraldipeptidyl peptidase 4 (DPP 4) inhibitor, in patients with type 2 diabetes who had inadequate glycaemic control[glycosylated haemoglobin (HbA1c) !7.5% and 10.5%] while on glimepiride alone or in combination withmetformin.
Methods: After a screening, diet/exercise run in and drug wash off period, a glimepiride Æ metformin dose titration/stabilization period and a 2 week, single blind placebo run in, 441 patients (of ages 18 75 years) were randomized toreceive the addition of sitagliptin 100 mg once daily or placebo in a 1 : 1 ratio for 24 weeks. Of these patients, 212 wereon glimepiride (!4 mg/day) monotherapy and 229 were on glimepiride (!4 mg/day) plus metformin (!1500 mg/day)combination therapy. Patients exceeding pre specified glycaemic thresholds during the double blind treatment periodwere provided open label rescue therapy (pioglitazone) until study end. The primary efficacy analysis evaluatedthe change in HbA1c from baseline to Week 24. Secondary efficacy endpoints included fasting plasma glucose (FPG),2 h post meal glucose and lipid measurements.
Results: Mean baseline HbA1c was 8.34% in the sitagliptin and placebo groups. After 24 weeks, sitagliptin reducedHbA1c by 0.74% (p < 0.001) relative to placebo. In the subset of patients on glimepiride plus metformin, sitagliptinreduced HbA1c by 0.89% relative to placebo, compared with a reduction of 0.57% in the subset of patients on glimepiride alone. The addition of sitagliptin reduced FPG by 20.1 mg/dl (p < 0.001) and increased homeostasismodel assessment b, a marker of b cell function, by 12% (p < 0.05) relative to placebo. In patients who underwenta meal tolerance test (n 134), sitagliptin decreased 2 h post prandial glucose (PPG) by 36.1 mg/dl (p < 0.001) rel ative to placebo. The addition of sitagliptin was generally well tolerated, although there was a higher incidence ofoverall (60 vs. 47%) and drug related adverse experiences (AEs) (15 vs. 7%) in the sitagliptin group than in the placebo group. This was largely because of a higher incidence of hypoglycaemia AEs (12 vs. 2%, respectively) in thesitagliptin group compared with the placebo group. Body weight modestly increased with sitagliptin relative to placebo (þ0.8 vs.
Conclusions: Sitagliptin 100 mg once daily significantly improved glycaemic control and b cell function in patientswith type 2 diabetes who had inadequate glycaemic control with glimepiride or glimepiride plus metformin therapy.
The addition of sitagliptin was generally well tolerated, with a modest increase in hypoglycaemia and body weight,consistent with glimepiride therapy and the observed degree of glycaemic improvement.


Microsoft word - seizures-treatment of resistant cases.docx

Marc Kent, DVM, DACVIM (Smal Animal and Neurology) Simon R. Platt, BVM&S, MRCVS, DACVIM (Neurology), DECVN ANTIEPILEPTIC DRUGS FOR EMERGENCY DRUGS RESISTANT CASES Diazepam Diazepam ( Valium ) is not a new drug and is widely used in the Treatment Options emergency treatment of seizures. Diazepam is often used in hos- Several newer drugs are available for treating s

Scene 1 Narrator #1 : This year’s Purim Shpiel takes place in________. Where we find the characters of ________. King Ahashveros is ________. Vashti is_______, Mordechai is ___________. Narrator #2 : Esther is _______. Haman is ________. Narrator#1 : King Ahashveros is hosting a grand party. All the guests are dancing the hora and having a wonderful time. Narrator #2 : Let's all go

Copyright © 2018 Medical Abstracts