Inflammation, Vol. 30, No. 6, December 2007 (# 2007)DOI: 10.1007/s10753-007-9041-3
The Effects of High Dose Pravastatin and Low DosePravastatin and Ezetimibe Combination Therapy on Lipid,Glucose Metabolism and Inflammation
Necati Dagli,1,2 Mustafa Yavuzkir,1 and Ilgin Karaca1
Objective. Coronary artery disease (CAD) is presently the major cause of mortality and morbidity. Anti-hyperlipidemic treatment is one of the main treatment steps in the management of CAD. Statins are thecornerstones in this treatment. Ezetimibe can be reliably used, when statins prove ineffective in treatment,or to reduce their side effects. In the present study we examined the effects of high-dose pravastatin (40 mg)and low-dose pravastatin (10 mg) + ezetimibe (10 mg) combination therapy on lipid and glucose mechanism,as well as inflammation.
Methods. This study registered 100 cases. Of the cases, 50 [57.1 T 11.1 years (24 (48%) females and 26(52%) males)] were administered 40 mg/day pravastatin (group 1) and 50 [53.2 T 12.2 years (27 (54%)females and 23 (46%) males)] were administered 10 mg pravastatin + 10 mg ezetimibe (group 2).
Results. In group 1, total cholesterol fell from 231.1 T 83.5 mg/dl to 211.3 T 37.2 mg/dl (p = 0.03), triglyceridefrom 243.5 T 96.8 mg/dl to 190.9 T 55.2 mg/dl (p = 0.003), and LDL cholesterol from 165.7 T 29.7 mg/dl to133.4 T 26.6 mg/dl (p = 0.02). In group 2, total cholesterol dropped from 250.9 T 51.8 mg/dl to 187.9 T 34.9mg/dl (p = 0.001), triglyceride from 270.3 T 158.9 mg/dl to 154.6 T 60.7 mg/dl (p = 0.001), and LDLcholesterol from 158.1 T 47.5 mg/dl to 116.9 T 26.4 mg/dl (p = 0.001). Insulin resistance decreased from4.05 T 2.31 to 3.16 T 1.90 (p=0.07) in group 1 and from 2.96 T 1.50 to 2.05 T 0.55 (p=0.009) in group 2.
High sensitive C-reactive protein fell from 6.69 T 6.11 mg/l to 3.02 T 1.70 mg/l (p=0.01) in group 1 and from6.36 T 2.06 mg/l to 2.68 T 1.69 mg/l (p=0.001) in group 2.
Conclusion. Both therapy regimes are effective. However, we found that low-dose pravastatin and ezetimibecombination therapy is more effective than high-dose pravastatin therapy on lipid metabolism, glucose metab-olism and inflammation.
KEY WORDS: ezetimibe; pravastatin; hyperlipidemia; inflammation; insulin resistance.
ing aim of primary and secondary prevention isrestoration of elevated LDLYcholesterol (LDLYC)
Coronary heart diseases (CAD) are among impor-
It is known that the highest benefit is reaped from
tant causes of mortality and morbidity, despite the
aggressive LDLYC treatment in coronary artery disease.
recent developments Hypercholesterolemia, inflam-
However, high-dose statin monotherapy either proves
mation and insulin resistance have a significant part in
ineffective or does not bring about the targeted lipid
the development and progression of CAD. The forego-
Lipid-lowering therapy is a cornerstone in prevent-
ing coronary artery disease, particularly in high-risk
1 Departments of Cardiology, Firat University, School of Medicine,
patients and coroner artery disease .The 3-hydroxy-3-
methylglutaryl coenzyme A (HMGYCoA) reductase
To whom correspondence should be addressed at Firat (Euphrates)
inhibitors (statins) are the most potent and commonly
¨ niversitesi, Firat Tip Merkezi, Kardiyoloji Anabilim Dali, 23119,
Elazig, Turkey. E-mail: [email protected]
prescribed drugs for the treatment of hypercholesterol-
0360-3997/07/0600-0230/0 # 2007 Springer Science + Business Media, LLC
High Deductible Health Plan (HDHP) - Health Savings Account (HSA) Preventive Therapy Drug List (10/01/11) ANTICONVULSANTS ORAL ANTIANGINAL AGENTS COMBINATION ANTIHYPERLIPIDEMICS DIABETES SL and chewable formulations are not included DIAGNOSTIC AGENTS TRANSDERMAL/TOPICAL ANTIANGINAL INJECTABLE DIABETES AGENTS CORONARY ARTERY DISEASE ANTIHYPERLIPIDE
October Board Report - Starts GoalMaiya Anderson and Clare DurandWith the new board year, we have been newly assigned to take over the starts goal of the strategic plan. We have identified our respective areas of interest and expect to split the work with Maiya focusing primarily on marketing strategies and use of social media and Clare focusing primarily on working directly with clubs on event pr