Product Name: Genesis Pour-On Ivermectin Endectocide for Page: 1 of 5 This revision February, 2008 MATERIAL SAFETY DATA SHEET Section 1 - Identification of Chemical Product and Company Ancare Australia Pty Limited Phone: 1800 001 973 Level 6, 79 George Street Phone: 02 9893 0071 Parramatta NSW 2150 Fax: 02 9893 0099 Substance: Trade Name: Genesis Pour-On Ivermectin Endectocide for Cattle Product Code: KGPO Product Use:
Control of parasites in cattle; for use as described on the product label.
Creation Date: April, 2005 Revision Date: February, 2008 Section 2 - Hazards Identification Statement of Hazardous Nature This product is classified as: Hazardous according to the criteria of NOHSC Australia.
Not a Dangerous Good according to the Australian Dangerous Goods (ADG) Code. However, this is a C1 Combustible Liquid and for storage meets the definition of Dangerous Goods.
Risk Phrases: R22, R51/53. Harmful if swallowed. Toxic to aquatic organisms, may cause long-term adverse effects to the aquatic environment. Safety Phrases: S20, S61, S24/25. When using, do not eat or drink. Avoid release to the environment. Refer to special instructions/Safety Data Sheets. Avoid contact with skin and eyes. SUSDP Classification: S5 ADG Classification: None allocated. Not a Dangerous Good under the ADG Code. UN Number: None allocated Emergency Overview Physical Description & Colour: Clear liquid. Odour: No data. Major Health Hazards: harmful if swallowed. Potential Health Effects Inhalation Short Term Exposure: Significant inhalation exposure is considered to be unlikely. Available data indicates that this product is not harmful. In addition product is unlikely to cause any discomfort or irritation. Long Term Exposure: No data for health effects associated with long term inhalation. Skin Contact: Short Term Exposure: Available data indicates that this product is not harmful. It should present no hazards in normal use. In addition product is unlikely to cause any discomfort in normal use. Long Term Exposure: No data for health effects associated with long term skin exposure. Eye Contact: Short Term Exposure: Exposure via eyes is considered to be unlikely. This product is believed to be not irritating to eyes. Long Term Exposure: No data for health effects associated with long term eye exposure. Ingestion: Short Term Exposure: Significant oral exposure is considered to be unlikely. Available data shows that this product is harmful, and is likely to cause headache and gastric disturbance such as nausea and vomiting if ingested in significant quantities. Long Term Exposure: No data for health effects associated with long term ingestion. Carcinogen Status: NOHSC: No significant ingredient is classified as carcinogenic by NOHSC. Issued by Ancare Australia Pty Ltd Phone: 1800 001 973 Product Name: Genesis Pour-On Ivermectin Endectocide for Page: 2 of 5 This revision February, 2008 MATERIAL SAFETY DATA SHEET NTP: No significant ingredient is classified as carcinogenic by NTP. IARC: No significant ingredient is classified as carcinogenic by IARC. Section 3 - Composition/Information on Ingredients Ingredients Conc,%w/v TWA (mg/m3) STEL
This is a commercial product whose exact ratio of components may vary slightly. Minor quantities of other non hazardous ingredients are also possible. The TWA exposure value is the average airborne concentration of a particular substance when calculated over a normal 8 hour working day for a 5 day working week. The STEL (Short Term Exposure Limit) is an exposure value that should not be exceeded for more than 15 minutes and should not be repeated for more than 4 times per day. There should be at least 60 minutes between successive exposures at the STEL. The term "peak "is used when the TWA limit, because of the rapid action of the substance, should never be exceeded, even briefly.
Section 4 - First Aid Measures General Information: You should call The Poisons Information Centre if you feel that you may have been poisoned, burned or irritated by this product. The number is 13 1126 from anywhere in Australia (0800 764 766 in New Zealand) and is available at all times. Have this MSDS with you when you call. Inhalation: First aid is not generally required. If in doubt, contact a Poisons Information Centre or a doctor. Skin Contact: No specific health data is available for this product. If any unusual symptoms become evident, or if in doubt, wash skin with soap and water and contact a Poisons Information Centre or a doctor. Eye Contact: Quickly and gently blot material from eyes. First aid is not generally required. If in doubt, contact a Poisons Information Centre or a doctor. Ingestion: If swallowed, do NOT induce vomiting. Wash mouth with water and contact a Poisons Information Centre, or call a doctor. Section 5 - Fire Fighting Measures Fire and Explosion Hazards: This product is classified as a C1 combustible product. There is no risk of an explosion from this product under normal circumstances if it is involved in a fire. Violent steam generation or eruption may occur upon application of direct water stream on hot liquids. Fire decomposition products from this product may be toxic if inhaled. Take appropriate protective measures. Extinguishing Media: Preferred extinguishing media are carbon dioxide, dry chemical, foam, water fog. Fire Fighting: If a significant quantity of this product is involved in a fire, call the fire brigade. Flash point: 61-150°C Upper Flammability Limit: No Lower Flammability Limit: No Autoignition temperature: No Flammability Class: C1 Section 6 - Accidental Release Measures Accidental release: In the event of a major spill, prevent spillage from entering drains or water courses. If a significant quantity of this product enters water courses, immediately advise local authorities as this product is toxic to aquatic organisms. As a minimum, wear overalls, goggles and gloves. Suitable materials for protective clothing include rubber, PVC. Eye/face protective equipment should comprise as a minimum, protective goggles. If there is a significant chance that vapours or mists are likely to build up in the cleanup area, we recommend that you use a respirator. Usually, no respirator is necessary when using this product. However, if you have any doubts consult the Australian Standard mentioned below (section 8). Stop leak if safe to do so, and contain spill. Absorb onto sand, vermiculite or other suitable absorbent material. If spill is too large or if absorbent material is not available, try to create a dike to stop material spreading or going into drains or waterways. Sweep up and shovel or collect recoverable product into labelled containers for recycling or salvage, and dispose of promptly. Can be slippery on floors, especially when wet. Recycle containers wherever possible after careful cleaning. Refer to product label for specific instructions. After spills, wash area preventing runoff from entering drains. If a significant quantity of material enters drains, advise emergency services. Full details regarding disposal of used containers, spillage and unused material may be found on the label. If there is any conflict between this MSDS Issued by Ancare Australia Pty Ltd Phone: 1800 001 973 Product Name: Genesis Pour-On Ivermectin Endectocide for Page: 3 of 5 This revision February, 2008 MATERIAL SAFETY DATA SHEET
and the label, instructions on the label prevail. Ensure legality of disposal by consulting regulations prior to disposal. Thoroughly launder protective clothing before storage or re-use. Advise laundry of nature of contamination when sending contaminated clothing to laundry.
Section 7 - Handling and Storage Handling: Keep exposure to this product to a minimum, and minimise the quantities kept in work areas. Check Section 8 of this MSDS for details of personal protective measures, and make sure that those measures are followed. The measures detailed below under "Storage" should be followed during handling in order to minimise risks to persons using the product in the workplace. Also, avoid contact or contamination of product with incompatible materials listed in Section 10. Storage: This product is a Scheduled Poison. Observe all relevant regulations regarding sale, transport and storage of this schedule of poison. Note that this product is combustible and therefore, for Storage, meets the definition of Dangerous Goods in some states. If you store large quantities (tonnes) of such products, we suggest that you consult your state's Dangerous Goods authority in order to clarify your obligations regarding their storage. Store in the closed original container in a dry, cool, well-ventilated area out of direct sunlight. Make sure that the product does not come into contact with substances listed under "Incompatibilities" in Section 10. Some liquid preparations settle or separate on standing and may require stirring before use. Check packaging - there may be further storage instructions on the label. Section 8 - Exposure Controls and Personal Protection
The following Australian Standards will provide general advice regarding safety clothing and equipment:
Respiratory equipment: AS/NZS 1715, Protective Gloves: AS 2161, Industrial Clothing: AS2919, Industrial Eye Protection: AS1336 and AS/NZS 1337, Occupational Protective Footwear: AS/NZS2210. Exposure Limits TWA (mg/m3) STEL
Exposure limits have not been established by NOHSC for any of the significant ingredients in this product.
The ADI for Ivermectin is set at 0.001mg/kg/day. The corresponding NOEL is set at 0.1mg/kg/day. ADI means Acceptable Daily Intake and NOEL means No-observable-effect-level. Values taken from Australian ADI List, Dec 2004.
No special equipment is usually needed when occasionally handling small quantities. The following instructions are for bulk handling or where regular exposure in an occupational setting occurs without proper containment systems. Ventilation: No special ventilation requirements are normally necessary for this product. However make sure that the work environment remains clean and that vapours and mists are minimised. Eye Protection: Eye protection is not normally necessary when this product is being used. However, if in doubt, wear suitable protective glasses or goggles. Skin Protection: The information at hand indicates that this product is not harmful and that normally no special skin protection is necessary. However, we suggest that you routinely avoid contact with all chemical products and that you wear suitable gloves (preferably elbow-length) when skin contact is likely. Protective Material Types: We suggest that protective clothing be made from the following materials: rubber, PVC. Respirator: Usually, no respirator is necessary when using this product. However, if you have any doubts consult the Australian Standard mentioned above. Section 9 - Physical and Chemical Properties: Physical Description & colour: Clear Odour: No Boiling Point: Not Freezing/Melting Point:
No specific data. Liquid at normal temperatures.
Volatiles:
No specific data. Expected to be low at 100°C.
Vapour Pressure:
Negligible at normal ambient temperatures.
Vapour Density: No Specific Gravity: Water Solubility: Insoluble. pH: No Volatility:
Negligible at normal ambient temperatures.
Odour Threshold: No Issued by Ancare Australia Pty Ltd Phone: 1800 001 973 Product Name: Genesis Pour-On Ivermectin Endectocide for Page: 4 of 5 This revision February, 2008 MATERIAL SAFETY DATA SHEET Evaporation Rate: No Coeff Oil/water Distribution: No Viscosity: Autoignition temp: No Section 10 - Stability and Reactivity Reactivity: This product is unlikely to react or decompose under normal storage conditions. However, if you have any doubts, contact the supplier for advice on shelf life properties. Conditions to Avoid: Store in the closed original container in a dry, cool, well-ventilated area out of direct sunlight. Incompatibilities: strong oxidising agents. Fire Decomposition: Carbon dioxide, and if combustion is incomplete, carbon monoxide and smoke. Water. Carbon monoxide poisoning produces headache, weakness, nausea, dizziness, confusion, dimness of vision, disturbance of judgment, and unconsciousness followed by coma and death. Polymerisation: This product will not undergo polymerisation reactions. Section 11 - Toxicological Information
From plasma analyses in humans and in laboratory animals, after oral and/or parenteral administration of Ivermectin, the following half-lives have been calculated . SPECIES
Metabolism: Ivermectin undergoes metabolism and is excreted mainly in the faeces. Ivermectin is little metabolised by mammals; 90% of the administered dose is excreted in the faeces and tissue residues are of the parent compound. Elimination by route of exposure: Ivermectin is excreted mainly in the faeces (unchanged), less than 1% appearing in the urine and less than 2% in breast milk. In animal studies, regardless of whether Ivermectin is administered parenterally or orally, only 0.5 to 2% of the dose is excreted in urine; the remainder (about 90%) appears in the faeces.
Section 12 - Ecological Information IVERMECTIN: Very toxic to certain aquatic species. LC50 - Daphnia magna, 48 hours = 0.025 ppb; NOEL Daphnia magna = 0.01 ppb; LC50 - Rainbow trout, 96 hours = 3.0 ppb; LC50 - Bluegill sunfish, 96 hours = 4.8 ppb. ENVIRONMENTAL FATE: (persistence, degradation, hydrolytic/photolytic stability, etc.): Ivermectin photodegrades rapidly in the environment and is metabolized in the soil. Water solubility is limited and it binds to soil very tightly. It does not bioconcentrate in fish and is not taken up from soil to plants. Both aquatic and terrestrial studies confirm rapid degradation of Ivermectin in the environment and lack of accumulation and persistence. Section 13 - Disposal Considerations Disposal: There are many pieces of legislation covering waste disposal and they differ in each state and territory, so each user must refer to laws operating in their area. In some areas, certain wastes must be tracked. The Hierarchy of Controls seems to be common - the user should investigate: Reduce, Reuse, and Recycle and only if all else fails should disposal be considered. Note that properties of a product may change in use, so that the following suggestions may not always be appropriate. The following may help you in properly addressing this matter for this product. Special help is available for the disposal of Agricultural Chemicals. The product label will give general advice regarding disposal of small quantities, and how to cleanse containers. However, for help with the collection of unwanted rural chemicals, contact ChemClear 1800 008 182 http://www.chemclear.com.au/ and for help with the disposal of empty drums, contact DrumMuster http://www.drummuster.com.au/ where you will find contact details for your area. Section 14 - Transport Information ADG Code: This product is not classified as a Dangerous Good. No special transport conditions are necessary unless required by other regulations. Issued by Ancare Australia Pty Ltd Phone: 1800 001 973 Product Name: Genesis Pour-On Ivermectin Endectocide for Page: 5 of 5 This revision February, 2008 MATERIAL SAFETY DATA SHEET Section 15 - Regulatory Information AICS: All of the significant ingredients in this formulation are to be found in the public AICS Database. The following ingredient: Ivermectin, is mentioned in the SUSDP. Section 16 - Other Information This MSDS contains only safety-related information. For other data see product literature. Acronyms: ADG Code
Australian Code for the Transport of Dangerous Goods by Road and Rail
Australian Inventory of Chemical Substances
CAS Number
Chemical Abstracts Service Registry Number
Hazchem Number
Emergency action code of numbers and letters that provide information to emergency services especially firefighters
International Agency for Research on Cancer
National Occupational Health and Safety Commission
R-Phrase Risk
Standard for the Uniform Scheduling of Drugs & Poisons
UN Number United
THIS MSDS SUMMARISES OUR BEST KNOWLEDGE OF THE HEALTH AND SAFETY HAZARD INFORMATION OF THE PRODUCT AND HOW TO SAFELY HANDLE AND USE THE PRODUCT IN THE WORKPLACE. EACH USER MUST REVIEW THIS MSDS IN THE CONTEXT OF HOW THE PRODUCT WILL BE HANDLED AND USED IN THE WORKPLACE.
IF CLARIFICATION OR FURTHER INFORMATION IS NEEDED TO ENSURE THAT AN APPROPRIATE RISK ASSESSMENT CAN BE MADE, THE USER SHOULD CONTACT THIS COMPANY SO WE CAN ATTEMPT TO OBTAIN ADDITIONAL INFORMATION FROM OUR SUPPLIERS
Please read all labels carefully before using product.
This MSDS is prepared in accord with the NOHSC document “National Code of Practice for the
Preparation of Material Safety Data Sheets” 2nd Edition [NOHSC:2011(2003)]
Copyright Kilford & Kilford Pty Ltd, February, 2008.
Issued by Ancare Australia Pty Ltd Phone: 1800 001 973
Journal of Kathmandu Medical College, Vol. 2, No. 2, Issue 4, Apr.-Jun., 2013Sanjaya Mani Dixit, Lecturer, Department of Pharmacology, Kathmandu Medical College Teaching Hospital, Kathmandu, Nepal Abstract Background: AL
Montpellier, Francia a 21 de junio de 2007 DR. POLIOPTRO MARTINEZ AUSTRIA DIRECTOR GENERAL DEL INSTITUTO MEXICANO DE TECNOLOGÍA DEL AGUA P R E S E N T E Es del dominio público que durante la administración que le precedió, el IMTA fue utilizado para fines facciosos de intereses personales; entre otros, en flagrante abuso de autoridad, el ex-director empleaba los recursos del Estado y