Use of Amber Acid and other components of energy balance for treatment of oncological cases
German physiologist Otto Warburg set up the hypothesis, which claims that the cause of cancer
can be found in the absence of oxygen. It happens due to various reasons, and is considered to be the
first step towards cellular disorders. Those disorders may become malignant. In the case of
permanent insufficiency of oxygen one part of the cel s perishes, another part adapts to the newly
formed conditions. The latter part of the cells causes a great activity of glycolysis and like so it fills
energy deficit. According to Warburg’s mind, respiration disorder is the basis of re-formation of
healthy cells to cancerous. Such a disorder may emerge in consequence of various reasons. The most
important of them is the disorder of oxygen-supply.
Nevertheless, not every respiration disorder causes cancer. These are the conditions that cause
• Respiration disorder must be reversible, i.e. it must remain after the extraction of
• Respiration disorder is not supposed to be such as to cause cells losses, according to
Warburg, a sudden loss of oxygen or high concentration of toxic are more dangerous than
low and permanent influence of these factors.
• Respiration disorder must remain during the cel division, i.e. it becomes genetically
• Respiration disorder cannot have influence on glycolysis.
• Respiration disorder should not rebound on cel ular respiration.
In that case, respiration disorder may become carcinogenic.
The conversion of normal cells into cancerous comes along in two stages. In the first stage, after
the occurence of respiration disorder, long period of the struggle for existence of cell begins. It is
true to think that the only latent period of cancer formation is none other than period, during which
the selection of cel s happens and the glycolysis of the tissue intensifies, after the respiration
disorder. Respiration disorder may be associated with the decrease number of mitochondrions in
Warburg thought that respiration of cancerous cel s is not just simply weak, but weak in
comparison with real y intensive aerobic glycolysis. Thus, the respiration of cancerous cel s becomes
inferior with regard to quality (stopping of respiration, oxidation and phosphorilation). Warburg’s
theory was criticized more than once. Til now the question, weather disorder of mitochondrions
may be a reason of the conversion of normal cel into cancerous, is open. The main goal of this work
is the testing of the state cells mitochondrions and search for the influence on cancerous cells. This,
in turn, lets heal the owner of those cel s, carrier of cancer.
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There were exams on three types of respiration of human’s cancerous cells and ultra-structures:
specifical y, ovarian cancer (OV), stomach cancer (CaVe) and mesenchymoma of connective tissue
(Sa19). It is proven that great activity of glucose and weak respiration of the OV cel s comes to the
top. A number of mitochondrions, compared together with normal cells, decreases there. According
to their external look, they were similar to mitochondrions, which are affected by the unhealthy
agent for the respiration – cyanide: mitochondrions were 2 – 3 times longer. CaVe and Sa19 were
breathing, though glucose was increased in them also. Populations of mitochondrions were
heterogeneous in Sa19 cel s: a lot of swol en mitochondrions. Majority of organoids were in, known
as, mediate (with the optimum amount of energy) state. Smal , newly formed mitochondrions are
also observed. The facts suggest that activity of mitochondrions population in Sa19 cell is high. The
look of CaVe cells and their mitochondrions is similar to Sa19, but the former are not so active and
pro-mitochondrions can be seen only after irradiation of the tissue.
Rapidity of respiration, rates of conjugation of mitochondrions and amount of ATP in cel s of Sa19
АDP/О Control of respiration (by Chance)
Amount of ATP in cel s of Sa19mitochondrions
Amount of ATP after addition of synthesized ADP
As shown in the Table 1 and Table 2, mitochondrions, which are abstracted from Sa19 cel s, has
a high rapidity of respiration, but rates of conjugation are reduced in them. Amount of endogenous
ATP is lesser than in mitochondrions of normal tissue. Synthesis of ATP is fairly active.
Another set of experiments shows the rates of conjugation of cel s respiration and
mitochondrions. They are abstracted from rat hepathoma 22, from liver of rats, which has tumour,
from laboratorial y affected liver of rats (the expansion of tumor stopped for them after vaccination)
Respiration of mitochondrions, which are abstracted form various liver of rats. Substratum of www.balticamber.ie [email protected] oxidation – glutamine acid (5 mg/ml).
3. Laboratorial y affected liver of rats
P1-2<0,05 p3-2<0,05 p3-1<0,05 p3-4<0,05
From the Table 3 it may be noticed that rapidity of respiration of mitochondrions, which are
abstracted from hepathoma, is rather higher in the liver of rats, which has tumour. Though, the rates
of conjugations are almost the same. We are of the opinion that it reports about the activity of energy
reactions in hepathoma (conjugation of variable mitochondrions) and their reduction in
mitochondrions of liver of rats, which has tumour. High rapidity of respiration and great rates of
conjugation is characteristic of mitochondrions of liver of rats affected under conditions of
The count, basical y, confirms Warburg’s hypothesis, analyzing respiration disorder of cancerous cel s in a wider meaning: like respiration changes and energy reactions. Therein lies, that it is possible to try to cure cancerous cel s, by regeneration normal circulatory system. Herewith it helps organism, which carries cancer, to fight against this trouble.
A group of doctors of Moscow 40th hospital fol owed our recommendations for usage of Amber
Acid (AA) together with citric acid, alpha-ketoglutarate acid, vitamins and some other medical
plants. This treatment was for volunteers. During the course of treatment patients were on almost
vegetarian, anti-diabetic diet. They were taking vitamins together with special medical agents of
treatment. Observation period was 5 years. Patients of 2-3 stage of disease were supervised.
Treatment proceeded til and after the radical operation.
Influence of Amber Acid (together with citric acid and 2-oxo-glutaric acid on mortality of
oncological patient in a course of five years (%).
www.balticamber.ie [email protected] The facts suggest that AA may be successfully used for healing oncological patients other type of results of circulatory system disorder.
Inst. of Biophysics, Moscow, Russian Federation
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Tratto dalle Linee Guida Italiane 2009 del Progetto Mondiale per la BPCO Cos’è la BPCO o BroncoPatia Cronica Ostruttiva ? La broncopneumopatia cronica ostruttiva consiste in un’ostruzione irreversibile delle vie aeree (bronchiolite) e una distruzione di aree polmonari (enfisema) causate principalmente dal fumo di sigaretta. Si manifesta clinicamente con progressiva mancanza di respiro
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