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SIGMA-ALDRICH MATERIAL SAFETY DATA SHEET Date Printed: 08/27/2008 Date Updated: 08/13/2008 Version 1.5 Section 1 - Product and Company Information Product Name TETRACYCLINE Product Number 87128 Brand FLUKA Company Sigma-Aldrich Address 3050 Spruce Street SAINT LOUIS MO 63103 US Technical Phone: 800-325-5832 Fax: 800-325-5052 Emergency Phone: 314-776-6555 Section 2 - Composition/Information on Ingredient Substance Name CAS # SARA 313 TETRACYCLINE FREE BASE 60-54-8 No Formula C22H24N2O8 Synonyms Abramycin * Abricycline * Achromycin (naphthracene derivatives) * Agromicina * Ambramicina * Ambramycin * Amycin * Biocycline * Cefracycline suspension * Criseociclina * Cyclomycin * Cytome * Deschlorobiomycin * Hostacyclin * Liquamycin * Medocycline * 6-Methyl-1,11-dioxy-2-naphthacenecarboxamide * Micycline * Neocycline * Oletetrin * Omegamycin * Orlycycline * Panmycin * Polycycline (antibiotic) * Resteclin * Roviciclina * Sumycin syrup * Tetrabon * Tetra-Co * Tetracycline * Tetracycline I * Tetracycline II * Tetracyn * Tetradecin * Tetrafil * Tsiklomitsin * T-125 * Veracin * Vetacyclinum RTECS Number: QI8750000 Section 3 - Hazards Identification EMERGENCY OVERVIEW Harmful.
Harmful if swallowed.
Photosensitizer. Calif. Prop. 65 developmental hazard. Target organ(s): Liver. Teeth. Bones.
HMIS RATING HEALTH: 3* FLAMMABILITY: 0 REACTIVITY: 1 NFPA RATING HEALTH: 3 FLAMMABILITY: 0 REACTIVITY: 1 *additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures ORAL EXPOSURE If swallowed, wash out mouth with water provided person is conscious. Call a physician.
INHALATION EXPOSURE If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures FLASH POINT N/A AUTOIGNITION TEMP N/A FLAMMABILITY N/A EXTINGUISHING MEDIA Suitable: Noncombustible. Use extinguishing media appropriate to surrounding fire conditions.
FIREFIGHTING Protective Equipment: Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
Section 6 - Accidental Release Measures PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S) Wear self-contained breathing apparatus, rubber boots, and heavy rubber gloves.
METHODS FOR CLEANING UP Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Section 7 - Handling and Storage HANDLING User Exposure: Do not breathe dust. Avoid contact with eyes, FLUKA - 87128 www.sigma-aldrich.com Page 2 skin, and clothing. Avoid prolonged or repeated exposure.
STORAGE Suitable: Keep tightly closed.
Store at 2-8°C SPECIAL REQUIREMENTS Light sensitive.
Section 8 - Exposure Controls / PPE ENGINEERING CONTROLS Safety shower and eye bath. Mechanical exhaust required.
PERSONAL PROTECTIVE EQUIPMENT Respiratory: Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Where risk assessment shows air-purifying respirators are appropriate use a dust mask type N95 (US) or type P1 (EN 143) respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES Wash thoroughly after handling.
Section 9 - Physical/Chemical Properties Appearance Color: Yellow Form: Powder Property Value At Temperature or Pressure Molecular Weight 444.43 AMU pH N/A BP/BP Range N/A MP/MP Range 172 °C Freezing Point N/A Vapor Pressure N/A Vapor Density N/A Saturated Vapor Conc. N/A SG/Density N/A Bulk Density N/A Odor Threshold N/A Volatile% N/A VOC Content N/A Water Content 4.0 - 11.0 % Solvent Content N/A Evaporation Rate N/A Viscosity N/A Surface Tension N/A Partition Coefficient N/A Decomposition Temp. N/A Flash Point N/A Explosion Limits N/A Flammability N/A Autoignition Temp N/A Refractive Index N/A Optical Rotation Degree of Rotation: 10 g/l Solvent: MeOH -291 - -236 (+/-5) Miscellaneous Data N/A FLUKA - 87128 www.sigma-aldrich.com Page 3 Solubility N/A N/A = not available Section 10 - Stability and Reactivity STABILITY Stable: Stable.
Conditions of Instability: May discolor on exposure to light.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide, Nitrogen oxides.
HAZARDOUS POLYMERIZATION Hazardous Polymerization: Will not occur Section 11 - Toxicological Information ROUTE OF EXPOSURE Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.
Ingestion: Harmful if swallowed.
SENSITIZATION Sensitization: Prolonged or repeated exposure may cause allergic reactions in certain sensitive individuals.
Skin: Can cause skin photosensitization.
TARGET ORGAN(S) OR SYSTEM(S) Liver. Teeth. Bones.
SIGNS AND SYMPTOMS OF EXPOSURE Can cause phototoxic reactions, gastrointestinal disturbances, turn teeth yellow and reduce mineralization.
TOXICITY DATA Multiple Woman 310 MG/KG LDLO Remarks: Liver:Jaundice, other or unclassified.
Gastrointestinal:Nausea or vomiting. Nutritional and Gross Metabolic:Changes in:Metabolic acidosis.
Oral Rat 807 mg/kg LD50 Intraperitoneal Rat 310 MG/KG LD50 Intravenous Rat FLUKA - 87128 www.sigma-aldrich.com Page 4 129 MG/KG LD50 Oral Mouse 678 mg/kg LD50 Intraperitoneal Mouse 120 MG/KG LD50 Subcutaneous Mouse 400 MG/KG LD50 Intravenous Mouse 157 MG/KG LD50 Oral Guinea pig 1875 mg/kg LD50 CHRONIC EXPOSURE - CARCINOGEN Result: This product is or contains a component that is probably not carcinogenic based on its IARC, ACGIH, NTP, or EPA classification.
CHRONIC EXPOSURE - TERATOGEN Result: Possible risk of congenital malformation in the fetus.
Species: Rat Dose: 100 UG/M3/24H Route of Application: Inhalation Exposure Time: (1-20D PREG) Result: Effects on Embryo or Fetus: Fetal death.
Species: Rat Dose: 1 MG/M3/24H Route of Application: Inhalation Exposure Time: (1-20D PREG) Result: Effects on Embryo or Fetus: Extra embryonic structures (e.g., placenta, umbilical cord).
Species: Rat Dose: 3 GM/KG Route of Application: Unreported Exposure Time: (9-14D PREG) Result: Effects on Embryo or Fetus: Fetal death.
Species: Mouse Dose: 700 MG/KG Route of Application: Oral Exposure Time: (14D POST) Result: Specific Developmental Abnormalities: Skin and skin appendages.
FLUKA - 87128 www.sigma-aldrich.com Page 5 Species: Mammal Dose: 55 MG/KG Route of Application: Intravenous Exposure Time: (8-18D PREG) Result: Effects on Embryo or Fetus: Fetotoxicity (except death, e.g., stunted fetus).
CHRONIC EXPOSURE - MUTAGEN Species: Mouse Route: Intraperitoneal Dose: 110 MG/KG Exposure Time: 24H Mutation test: Micronucleus test Species: S. typhimurium Mutation test: Histidine reversion (Ames) CHRONIC EXPOSURE - REPRODUCTIVE HAZARD Species: Woman Dose: 200 MG/KG Route of Application: Unreported Exposure Time: (34-35W PREG) Result: Effects on Newborn: Delayed effects.
Species: Woman Dose: 80 MG/KG Route of Application: Unreported Exposure Time: (1-39W PREG) Result: Effects on Newborn: Other postnatal measures or effects.
Species: Rat Dose: 10 GM/KG Route of Application: Oral Exposure Time: (8-21D PREG/7D POST) Result: Effects on Newborn: Behavioral.
Species: Rat Dose: 863 MG/KG Route of Application: Oral Exposure Time: (4D POST) Result: Effects on Newborn: Behavioral. Effects on Newborn: Physical.
Species: Rat Dose: 413 MG/KG Route of Application: Oral Exposure Time: (3D POST) Result: Effects on Newborn: Behavioral. Effects on Newborn: Physical.
Species: Rat Dose: 700 MG/KG Route of Application: Intramuscular Exposure Time: (8-14D PREG) Result: Effects on Fertility: Post-implantation mortality (e.g., dead and/or resorbed implants per total number of implants).
Section 12 - Ecological Information No data available.
FLUKA - 87128 www.sigma-aldrich.com Page 6 Section 13 - Disposal Considerations APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Observe all federal, state, and local environmental regulations.
Section 14 - Transport Information DOT Proper Shipping Name: None Non-Hazardous for Transport: This substance is considered to be non-hazardous for transport.
IATA Non-Hazardous for Air Transport: Non-hazardous for air transport.
Section 15 - Regulatory Information EU ADDITIONAL CLASSIFICATION Symbol of Danger: Xn Indication of Danger: Harmful.
R: 22 Risk Statements: Harmful if swallowed.
S: 22-36 Safety Statements: Do not breathe dust. Wear suitable protective clothing.
US CLASSIFICATION AND LABEL TEXT Indication of Danger: Harmful.
Risk Statements: Harmful if swallowed.
Safety Statements: Do not breathe dust. Wear suitable protective clothing.
US Statements: Photosensitizer. Calif. Prop. 65 developmental hazard. Target organ(s): Liver. Teeth. Bones.
UNITED STATES REGULATORY INFORMATION SARA LISTED: No UNITED STATES - STATE REGULATORY INFORMATION CALIFORNIA PROP - 65 California Prop - 65: This product is or contains chemical(s) known to the state of California to cause developmental toxicity. This product is or contains chemical(s) known to the state of California to cause developmental toxicity.
CANADA REGULATORY INFORMATION WHMIS Classification: This product has been classified in accordance with the hazard criteria of the CPR, and the MSDS contains all the information required by the CPR.
DSL: No NDSL: No Section 16 - Other Information DISCLAIMER For R&D use only. Not for drug, household or other uses.
FLUKA - 87128 www.sigma-aldrich.com Page 7 WARRANTY The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Inc., shall not be held liable for any damage resulting from handling or from contact with the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale.
Copyright 2008 Sigma-Aldrich Co. License granted to make unlimited paper copies for internal use only.
FLUKA - 87128 www.sigma-aldrich.com Page 8

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