Technology Review: TR University Research Scorecard
http://www.technologyreview.com/printer_friendly_article.aspx?id=125. TR University Research Scorecard Patenting and licensing at U.S. universities is going strong. Biotech in particular gets high marks.
The economy might be hiccupping toward an uncertain fate, but one of the engines of
innovation is still hitting on all cylinders. Technological advances emerging from the
nation's universities are finding their way into industry at a pace that has hardly
slackened in the last year. Institutions of higher learning do not cite patenting as a
primary goal; top priority still goes to research and teaching. But license fees from
existing patents, particularly in biotechnology, are generating hundreds of millions of
dollars that universities often plow back into research.
While the business world at large is coming to its senses after the Internet hysteria of
the past five years, the economics of university licensing seems to rest on more
enduring verities. The first is that true technological advances are economically
valuable. Another, more specific, truth is that new drugs that cure disease-or new ways
to find or make these drugs-are worth a lot of money. Finally, despite the glamour of
entrepreneurship, the big money for a university usually comes from patents licensed to
large, established companies-not startups. With a few high-profile exceptions (most
notably at MIT and Stanford, and in the University of California system), university
research spawns relatively few spinoff companies.
The "Campus Patenting" chart (in PDF version) gives a glimpse of which U.S.
universities are most productive in technological invention. The data, provided
exclusively to Technology Review by CHI Research of Haddon Heights, NJ, establish a
metric (called technological strength) that quantifies the power of a school's patent
portfolio. Another table (in PDF version) has a more mercenary flavor. Here we show
how much money leading research universities are reaping from licenses on the patents
they own; these statistics were compiled by the nonprofit Association of University
For those universities interested in maximizing licensing income, the lesson plan is
simple: biotech blockbusters. Chart-topping Columbia University illustrates the point.
Columbia hit the jackpot with the 1983 patent by Richard Axel on a method for
inserting DNA into cells-a procedure at the heart of the production of several of today's
Technology Review: TR University Research Scorecard
http://www.technologyreview.com/printer_friendly_article.aspx?id=125.
bestselling biotech drugs, including plasminogen activator, which if administered early
can lessen the damage inflicted by a heart attack. Indeed, about 80 percent of
Columbia's licensing revenue comes from fees paid to the university by pharmaceutical
companies for three technologies, according to Scot Hamilton, senior director of
Science and Technology Ventures-the university's technology transfer organization.
Biotech rules at other campuses, too. Two-thirds of the $74 million in licensing
revenues flowing into the University of California system comes from patents issued to
the University of California, San Francisco, School of Medicine; only about $8 million
of the total arises from patents issued to the system's flagship Berkeley campus,
according to William Hoskins, director of the Office of Technology Licensing at
Berkeley. For third-ranked Florida State University, virtually all of its $57 million in
licensing revenues comes from a patent by chemist Robert Holton on a method to
produce the tumor-fighting chemical paclitaxel-marketed by Bristol-Myers Squibb as
Taxol, the world's top-selling anticancer drug.
And the lion's share of Yale University's $40-plus million in licensing income comes
from an anti-retroviral drug called stavudine, which is marketed under the brand name
Zerit by Bristol-Myers Squibb and is one constituent of the anti-AIDS drug "cocktail."
Subtract the Zerit income from its portfolio and Yale's license revenue shrinks to about
$15 million, according to E. Jonathan Soderstrom, managing director of Yale's Office
While much of the action is at the elite private schools, several public universities have
made patents and technology transfer a big part of their strategies. The University of
California, with its nine campuses and almost $2 billion research budget, tops the field
in technological strength and comes in second only to Columbia in licensing income.
And the granddaddy of university technology transfer is far from the technology-
frenzied coasts. The University of Wisconsin-Madison has been licensing patents from
its research since 1925, when dairy scientist Harry Steenbock discovered an irradiation
process that could activate vitamin D in milk, notes Bryan Renk, director of patents
and licensing at the Wisconsin Alumni Research Foundation, which handles the
school's patent and license affairs. "Licensing is a big-hit game," says Renk, adding that
Wisconsin has produced a blockbuster "just about every decade." Another Midwestern
public university is rising fast in the licensing sweepstakes as well: Michigan State
University. The school owes most of last year's $24 million in revenue to patents
awarded to researcher Barnett Rosenberg for the anticancer drugs cisplatin and
carboplatin, which have dramatically lowered the mortality rate for patients with
testicular cancer and offer hope for improved treatment of ovarian and cervical cancer.
Driven in part by the prospect of dramatic licensing revenues, many universities are
cultivating a culture of entrepreneurship. No wonder, then, that campus technology
transfer offices are finding themselves an important stop on the tour when schools hire
Technology Review: TR University Research Scorecard
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new research talent. "We are heavily involved in faculty recruiting," says Yale's
Soderstrom. Renk says the same is becoming true at Michigan State. "New faculty are
more entrepreneurial," he says. "They come interview the technology transfer officers
and ask how well funded and well staffed we are." That way, prospective faculty can
get a read on the level of institutional support they will receive to move their inventions
out of the lab and into practical use.
A university's success in patent licensing depends on a number of factors. Columbia's
Hamilton attributes his school's success in part to a creative faculty that is willing to
disclose its inventions to a technology transfer office. One immutable circumstance:
location. Hamilton says New York City's business-friendly environment has been a
boon to spinoffs. "We're not so cloistered here-the faculty tend to be more worldly, and
we find that there is less prejudice" against commercializing the fruits of research,
While they work to make things as easy as possible, even the most successful patent-
licensing universities view income as a happy by-product. "Our main goal is to provide
a service to the faculty-to help them get their ideas out into practical use," says John
Ritter, director of the Office of Technology Licensing and Intellectual Property at
Princeton University. "If we get a revenue stream, that's gravy."
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