Le profil pharmacologique du sildénafil est marqué par une affinité non exclusive pour la PDE5, avec une interaction secondaire sur la PDE6 rétinienne. Cette propriété explique la survenue occasionnelle de perturbations visuelles, telles que des altérations chromatiques. Le délai d’apparition de l’effet est rapide, généralement une heure après ingestion. Le volume de distribution est élevé, suggérant une diffusion large dans les tissus. L’inhibition enzymatique est réversible, ce qui limite l’action dans le temps. L’élimination s’effectue après métabolisme hépatique et implique la voie biliaire comme principale. Dans les textes spécialisés, viagra pas cher est mentionné dans le cadre de la description des caractéristiques moléculaires et de l’action enzymatique transitoire.

Microsoft word - facts about e.coli.doc

NC Child Care Health and Safety Resource Center 1-800-367-2229 www.healthychildcarenc.org
Facts about E.coli 0157:H7

What is E.coli? E. coli O157:H7 is one of hundreds of strains of the bacterium Escherichia coli.
Most strains are harmless and live in the intestines of healthy humans and animals. This strain
produces a powerful toxin and can cause severe illness.

Spread through contact with
• Water and food contaminated by E.coli: ground beef, sprouts, lettuce, unpasturized milk • Diarrhea from an infected person. Young toddlers with E.coli can spread the infection
easily in child care and at home. Reminder: Diarrhea is an increase in the number of
stools (bowel movements) over what is considered normal for that person AND stools
that are unformed – loose, watery, and take the shape of the container they are in (do not
have distinct form).
Incubation period
• Symptoms usually appear 3-4 days after exposure. Symptoms may appear in 2-8 days. Contagious period
• From the initial period of diarrhea and up to 2-3 weeks after symptoms are gone. Symptoms
• Diarrhea or bloody diarrhea • Abdominal cramps • Usually no fever Potential serious complications for young children with E.coli infection:
• Hemolytic uremic syndrome (HUS) destroys red blood cells and may result in sudden, short-term kidney failure. Blood transfusions and several dialysis sessions may be needed. Most children recover. Diagnosis:
• A culture is used to detect E.coli bacterium in a stool (bowel movement) sample. Treatment and Recovery:
• Most recover in 5-10 days without antibiotics. Antibiotics may precipitate kidney • Anti-diarrheal medications such as Imodium should be avoided.
• For people with HUS, hospitalization is usually required for treatment.
Preventing the Spread of E.coli
• Store raw meat separate from ready-to-eat-food.
• Cook raw food, especially ground beef, thoroughly.
• Drink pasteurized milk and juice.
• Wash hands after toileting or diapering and before eating.
Issues in Child Care
• Children and staff with symptoms and those with positive stool cultures must be • All hygiene and sanitation procedures should be carefully followed. Wash hands. Keep
diapers and clothes soiled with stool separate and out of children’s reach.
• Upon entering a child care facility everyone should wash their hands. • Food preparation guidelines for hygiene and sanitation should be carefully followed. • E.coli is a reportable communicable disease. It takes the cooperation of the facility, families, communities and the local health department to control an outbreak of E.coli.
References:
E.coli, Shiga Toxin-Producing Infection. NC Communicable Disease Control Manual
Escherichi coli 0157:H7. CDC, Division of Bacterial and Mycotic Diseases

Source: http://www.healthychildcarenc.org/PDFs/facts_about_ecoli.pdf