Traci a

Traci A. Wilgus, Ph.D.
Phone: (614) 366-8526 Fax: (614) 366-9389
Education:
Bachelor of Science, Microbiology The Ohio State University, Columbus, OH Doctor of Philosophy, Molecular Virology, Immunology & Medical Genetics The Ohio State University, Columbus, OH Dissertation Title: Inflammation in ultraviolet light B-induced carcinogenesis, wound healing and fibrosis in adult and fetal murine skin.
Employment History:
Student Research Assistant (Dr. Michael Para) The Ohio State University, Division of Internal Medicine Assistant/Graduate Student (Dr. Tatiana Oberyszyn) The Ohio State University, Department of Molecular Virology, Immunology & Medical Genetics Research Associate/Postdoctoral Fellow (Dr. Tatiana Oberyszyn) The Ohio State University, Department of Pathology Associate/Postdoctoral Fellow (Dr. Luisa DiPietro) Loyola University Medical Center, Department of Surgery and Burn & Shock Trauma Institute University of Illinois at Chicago, Department of Periodontics and Center for Wound Healing & Tissue Regeneration Comprehensive Cancer Center, MCC Program
Publications:

TA Wilgus, MS Ross, ML Parrett and TM Oberyszyn. 2000. Topical application of a selective cyclooxygenase inhibitor suppresses UVB mediated cutaneous inflammation. Prostaglandins Other Lipid Mediat 62(4) 367-384. TM Oberyszyn, FM Robertson, KL Tober, MS Ross, ML Parrett, TA Wilgus, S Iyer, J Woo, and R Buelow. 2001. Inhibition of cutaneous ultraviolet light-induced tumor necrosis factor-alpha protein production by Allotrap 1258, a novel immunomodulatory peptide. Photochem Photobiol 73(2) 184-190. TA Wilgus, ML Parrett, MS Ross, KL Tober, FM Robertson and TM Oberyszyn. 2002. Inhibition of ultraviolet light B-induced cutaneous inflammation by a specific cyclooxygenase-2 inhibitor. Adv Exp Med Biol 507: 85-92. TA Wilgus, Y Vodovotz, E Vittadini, EA Clubbs, and TM Oberyszyn. 2003. Reduction of scar formation in full-thickness wounds with topical celecoxib treatment. Wound Repair Regen 11(1) 25-34. TA Wilgus, AT Koki, B Zweifel, PA Rubal, DF Kusewitt, and TM Oberyszyn. 2003. Inhibition of cyclooxygenase-2 activity with topical celecoxib blocks cutaneous ultraviolet light-B mediated inflammation and tumor formation. Mol Carcinog 38(2) 49-58. TA Wilgus, AT Koki, B Zweifel, PA Rubal, and TM Oberyszyn. 2003. Chemotherapeutic efficacy of topical celecoxib in a murine model of ultraviolet light B induced skin cancer. Mol Carcinog 38(1) 33-39. TA Wilgus, TS Breza, Jr., and TM Oberyszyn. 2004. Treatment with 5-fluorouracil and celecoxib displays synergistic regression of ultraviolet light B-induced skin tumors. J Invest Dermatol 122(6) 1488-1494. TA Wilgus, VK Bergdall, KL Tober, KJ Hill, S Mitra, NA Flavahan, and TM Oberyszyn. 2004. The impact of cyclooxygenase-2 mediated inflammation on scarless fetal wound healing. Am J Pathol 165(3): 753-761. TA Wilgus, VK Bergdall, LA DiPietro, and TM Oberyszyn. 2005. Hydrogen peroxide disrupts scarless fetal wound repair. Wound Rep Regen 13(5): 513-519. TA Wilgus, AM Matthies, KA Radek, J Dovi, A Burns, R Shankar, and LA DiPietro. 2005. Novel function for vascular endothelial growth factor receptor-1 on epidermal keratinocytes. Am J Pathol 167(5): 1257-1266. KL Tober, TA Wilgus, DF Kusewitt, JM Thomas-Ahner, T Maruyama, and TM Oberyszyn. 2006. Importance of the EP1 receptor in cutaneous UVB-induced inflammation and tumor development. J Invest Dermatol 126: 205-211. ME Kleinman, K Yamada, A Takeda, V Chandrasekaran, M Nozaki, JZ Baffi, RJC Albuquerque, S Yamasaki, M Itaya, Y Pan, B Appukuttan, D Gibbs, Z Yang, K Karikó, BK Ambati, TA Wilgus, LA DiPietro, E Sakurai, K Zhang, JR Smith, EW Taylor, and J Ambati. 2008. Sequence- and target-independent angiogenesis suppression by siRNA via TLR3. Nature 452(7187): 591-598. TA Wilgus, AM Ferreira, TM Oberyszyn, VK Bergdall, and LA DiPietro. 2008. Modulation of dermal scar formation by vascular endothelial growth factor. Lab Invest 88(6): 579-590. **Recommended by Faculty of 1000 Biology; Evaluation citation: ME Schrementi, TA Wilgus, A Chen, J Yoon, L He, and LA DiPietro. 2008. Blockade of mast cell reduces cutaneous inflammation and scar formation. In revision. Reviews and Book Chapters:
TA Wilgus. 2007. Regenerative healing in fetal skin: A review of the literature. Ostomy Wound Manage 53(6): 16-31. TA Wilgus. 2008. Immune cells in the healing skin wound: influential players at each stage of repair. Pharmacol Res 58(2): 112-116.
Memberships:


American Association for Cancer Research
American Society for Investigative Pathology
Awards and Honors:

First Place Talk, Graduate Student Colloquium, Ohio State University Travel Award to attend the Gordon Research Conference on Tissue Repair and Regeneration 2001 Cayman Chemical Travel Award to attend the Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Related Diseases Conference 2003 Travel Fellowship to attend the International Investigative Dermatology/Society of Investigative American Society for Investigative Pathology Merit Award Farber Travel Award to attend the Montagna Symposium on the Biology of Skin
Fellowships:

Efficacy of combination topical chemotherapy with celecoxib and 5-fluorouracil against ultraviolet-light B induced squamous cell carcinoma of the skin VEGF-induced angiogenesis and scar formation VEGF receptor signaling in dermal fibroblasts: implications for scarring
Grants:

FUNDED:
R01CA127109
NIH/NCI Keratinocyte responses to VEGF in carcinogenesis Role: Principle Investigator
This project will assess whether direct signaling of VEGF through VEGFR-1 in keratinocytes is involved in skin
carcinogenesis.
PENDING:
NIH - Harnessing Inflammation for Reconstruction of Oral and Craniofacial Tissues
Role: Co-Investigator (Sudha Agarwal, PI)

Department of Defense - Efficacy of dopamine antagonists in wound healing
Role: Consultant (Sujit Basu, PI)

SUBMITTED, NOT FUNDED:
R01
DNA-based vaccine for oral carcinoma Role: Co-Investigator (PI: Cohen) This project will determine the efficacy of a novel DNA vaccine approach in treating oral carcinoma.
Seminars and Oral Presentations:
2004 Inflammation, angiogenesis and scar formation, Department of Surgery/Burn & Shock Trauma Institute, 2004 Inflammation, angiogenesis and skin function, Skin Research Group, Ohio State University 2005 Modulation of dermal scar formation by VEGF, Department of Surgery/Burn & Shock Trauma Institute, 2005 VEGF-associated angiogenesis promotes cutaneous scar tissue deposition, Experimental Biology meeting 2005 American Society of Investigative Pathology Merit Award Presentation, Experimental Biology meeting 2005 Modulation of scar formation by vascular endothelial growth factor, Wound Healing Society meeting 2006 Modulation of wound scar formation by MCP-1, Experimental Biology meeting 2006 Fetal wound healing, Symposium on Advanced Wound Care meeting 2006 Non-endothelial influences of VEGF on wound healing, Wound Healing Society meeting 2006 Non-endothelial effects of VEGF in wound healing and skin carcinogenesis, Center for Molecular Biology of Oral Diseases, University of Illinois at Chicago 2007 New roles for VEGF in wound healing and skin carcinogenesis, Columbus Children’s Research Institute, 2007 Functional roles for VEGF in the skin: Not just for angiogenesis anymore, Department of Pathology, The 2008 Angiogenesis and Wound Repair, Wound Healing Research Group, DHLRI, The Ohio State University 2008 New roles for vascular endothelial growth factor in the skin. Clinical/Research Dermatology Retreat, The 2008 VEGF in skin carcinogenesis: Angiogenesis and beyond, Molecular Carcinogenesis and Chemoprevention Program, Comprehensive Cancer Center, The Ohio State University 2008 Inflammation and Angiogenesis in the Skin, Department of Pathology Research in Progress, The Ohio State
University

2008 Wound repair in the fetus: The key to perfect repair? Department of Pathology Grand Rounds, The Ohio
State University

Service – University (The Ohio State University):

Poster judge, OSU Medical Center Research Day Oral Presentation judge, Edward Hayes Research Forum Paper judge, Edward Hayes Research Forum Abstract/Poster judge, Biological Sciences Undergraduate Research Colloquium Poster judge, Denman Undergraduate Research Forum Committee member, Senior Thesis - Undergraduate Research (Jessica Rosette) Committee member, Ph.D. Dissertation - IBGP (F. Jason Duncan) Committee member, Ph.D. Dissertation – MCDB (Jessica Fleming) Graduate Faculty Representative, Ph.D. Dissertation – Microbiology (Daniele Vicari) Committee member, Pathology Graduate Studies Committee Committee member, Ph.D. Dissertation – IBGP (Nick Sullivan) Service – University (University of Illinois at Chicago):

Poster judge, UIC College of Dentistry Annual Clinic and Research Day Master’s degree committee member, Oral Sciences Program, Logesh Swayamprakasam Master’s degree committee member, Oral Sciences Program, Allison Yen Animal Care Committee (IACUC) – Teaching subcommittee Member Service – External:


Editorial Duties:
Managing Editor, special edition of Frontiers in Bioscience, ‘Emerging trends in wound repair’ (Launch date: January 2007) 2008-present Editorial Board Member, Ostomy Wound Management Archives of Dermatological Research BMC Cancer Frontiers in Bioscience Journal of the American College of Surgeons Journal of Burn Care & Rehabilitation Journal of Investigative Dermatology Molecular Carcinogenesis Regenerative Medicine Saudi Medical Journal Ad hoc reviewer, NSF CAREER Award, Developmental Systems Program, October 2007 Ad hoc reviewer, U.S. Army Research Office Grant, Life Sciences Division, October 2007 Reviewer, Local American Cancer Society, November 2007 Ad hoc reviewer, NIH Special Emphasis Panel, November 2007 Session moderator, Wound Healing Society Meeting, May 2006 2008-present Website Committee Member, Wound Healing Society External Promotion and Tenure Evaluation:
Advanced coursework:

2003 NCI-AACR sponsored Edward A. Smuckler Memorial Pathobiology of Cancer Workshop 2005 New England BioLabs Molecular Biology Summer Workshop
Formal Teaching:
2002 Lecture: Tissue remodeling and fetal wound healing, Ohio State University Course: Dentistry 803 - Wound healing: Molecular, Cellular & Clinical Aspects 2005 Lecture: Fetal wound healing: A tool for studying scar formation, Loyola University Course: Surgery - Integrated Basic Science and Critical Care Seminar Epithelial differentiation and repair, University of Illinois at Chicago Course: Oral Sciences 594 - Special Topics in Oral Sciences-Wound Healing Fetal wound healing, University of Illinois at Chicago Course: Oral Sciences 594 - Special Topics in Oral Sciences-Wound Healing 2007 Facilitator, Autoimmune disease small group discussions, University of Illinois at Chicago Course: MIMX 322 - Dental Microbiology and Immunology Cutaneous biology and skin disorders, Ohio State University Course: IBGP 706 - Faculty Research in Biomedical Science Course: BIOM SCI H720.01 - BMS Research Experience Course: IBGP 797.01 - Integrated Biomedical Science Graduate Seminar
Abstracts:

TA Wilgus, FM Robertson, ML Parrett, MS Ross, KL Tober, and TM Oberyszyn. 1999. Inhibition of ultraviolet light B-induced cutaneous inflammation by a specific cyclooxygenase-2 (COX-2) inhibitor. Presented at the Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Related Diseases Conference. Prostaglandins Other Lipid Mediat 59(1-6): 219. TA Wilgus, ML Parrett, MS Ross, and TM Oberyszyn. 2000. Topical application of a specific cyclooxygenase-2 inhibitor, celecoxib, inhibits the acute cutaneous ultraviolet light B mediated inflammatory response. Presented at the Am. Assoc. for Cancer Res. Meeting. Proc Am Assoc Cancer Res 41:493-494. TA Wilgus, MS Ross, ML Parrett, and TM Oberyszyn. 2000. Alleviation of acute UVB-mediated cutaneous inflammation by a specific cyclooxygenase-2 (COX-2) inhibitor. Presented at the Graduate Student Colloquium, Ohio State University. TA Wilgus, ML Parrett, MS Ross, and TM Oberyszyn. 2001. Topical application of a specific cyclooxygenase-2 inhibitor, celecoxib inhibits the acute cutaneous ultraviolet light B mediated inflammatory response. Presented at the Comprehensive Cancer Center Scientific Meeting, Ohio State University. TA Wilgus, MS Ross, and TM Oberyszyn. 2001. Topical application of the anti-inflammatory drug celecoxib reduces scarring after full-thickness incisional skin wounding. Presented at the Graduate Student Colloquium, Ohio State University. TA Wilgus, MS Ross, and TM Oberyszyn. 2001. Celecoxib inhibits cutaneous oxidative DNA damage induced by ultraviolet light. Presented at the Am. Assoc. for Cancer Res. Meeting. Proc Am Assoc Cancer Res 42: 573-574. AM VanBuskirk, TA Wilgus, and TM Oberyszyn. 2001. In vivo inhibition of plasmacytoma growth by the COX-2 inhibitor, celecoxib. Presented at the Am. Assoc. for Cancer Res. Meeting. Proc Am Assoc Cancer Res 42: 44. KL Tober, TM Oberyszyn, JA Holinga, MC Ullrich, TA Wilgus, MS Ross, and FM Robertson. 2001. Differential effects of selective inhibitors of constitutive or inducible nitric oxide synthase on angiogenesis in murine multi-stage carcinogenesis. Presented at the Am. Assoc. for Cancer Res. Meeting. Proc Am Assoc Cancer Res 42: 585. TA Wilgus, MS Ross, KL Tober, and TM Oberyszyn. 2001. Mechanism of chemoprevention by celecoxib: inhibition of oxidative DNA damage? Presented at the Keystone Symposia: Eicosanoid Lipid Mediators-Biochemistry, Molecular Biology and Pharmacology and Cell-Cell Interactions in Inflammation. TA Wilgus, MS Ross, and TM Oberyszyn. 2001. Topical application of the anti-inflammatory drug celecoxib reduces scarring after full-thickness incisional skin wounding. Presented at the Gordon Research Conference on Tissue Repair and Regeneration. TA Wilgus and TM Oberyszyn. 2001. Inhibition of scar formation in the skin after topical treatment with a cyclooxygenase-2 inhibitor. Presented at the Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Related Diseases Conference. TA Wilgus and TM Oberyszyn*. 2001. Inhibition of cyclooxygenase-2 activity blocks cutaneous ultraviolet light-B mediated inflammation and tumor formation. Presented at the Annual Congress of the Chilean Society of Pharmacology/Chilean Society of Physiological Sciences/Chilean Society of Biology Meeting, Pucon, Chile. *presenter TA Wilgus, AT Koki, B Zweifel, and TM Oberyszyn. 2002. Inhibition of cyclooxygenase-2 activity with topical celecoxib blocks cutaneous ultraviolet light-B mediated inflammation and tumor formation. Presented at the Comprehensive Cancer Center Scientific Meeting, Ohio State University. TA Wilgus, AT Koki, B Zweifel, and TM Oberyszyn. 2002. Inhibition of cyclooxygenase-2 activity with topical celecoxib blocks cutaneous ultraviolet light-B mediated inflammation and tumor formation. Presented at the Am. Assoc. for Cancer Res. Meeting. Proc Am Assoc Cancer Res 43:1144. TA Wilgus, NA Flavahan, S Mitra, and TM Oberyszyn. 2002. Potential targets for anti-scarring therapy: cyclooxygenase-2 and thrombospondin. Presented at the Society for Investigative Dermatology Meeting. J Invest Dermatol 119(1): 320. TA Wilgus and TM Oberyszyn. 2002. Inhibition of scar formation with topical celecoxib treatment. Presented at the Wound Healing Society Meeting. Wound Repair Regen 10(2): A61. TA Wilgus, VK Bergdall, and TM Oberyszyn. 2002. The promotion of scar formation in fetal wounds by hydrogen peroxide. Presented at the Wound Healing: Oxygen and Emerging Therapeutics Conference. TA Wilgus, TS Breza, Jr., JL Hatton, and TM Oberyszyn. 2003. Regression of ultraviolet light B induced skin tumors with 5-fluorouracil and celecoxib. Presented at the Am. Assoc. for Cancer Res. Meeting. Proc Am Assoc Cancer Res 44: 738-739. AM VanBuskirk, TM Oberyszyn, AE Parent, JL Hatton, TA Wilgus and DF Kusewitt. 2003. A murine model of increased skin cancer risk in immunocompromised patients. Presented at the Am. Assoc. for Cancer Res. Meeting. Proc Am Assoc Cancer Res 44: 758-759. TA Wilgus, TS Breza, Jr., JL Hatton, and TM Oberyszyn. 2003. Combination chemotherapy for the treatment of ultraviolet light B induced skin tumors using efudex and celecoxib. Presented at the Society of Investigative Dermatology meeting. J Invest Dermatol 121(1) 1210. TS Breza, Jr., TM Oberyszyn, and TA Wilgus. 2003. Regression of ultraviolet light induced skin tumors with the combination of 5-fluorouracil and celecoxib. Presented at the OSU Medical Center Graduate and Postgraduate Research Forum, Ohio State University. TA Wilgus, TS Breza, Jr., and TM Oberyszyn. 2003. The effects of 5-fluorouracil and celecoxib on apoptosis, proliferation, and the regression of ultraviolet light B induced skin tumors. Presented at the Edward A. Smuckler Memorial Pathobiology of Cancer Workshop. TA Wilgus, KL Tober, and TM Oberyszyn. 2003. Induction of the EP1 receptor in murine skin following acute and chronic UVB exposure. Presented at the Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Related Diseases Conference. TA Wilgus, TM Oberyszyn, VK Bergdall, and LA DiPietro. 2004. Characterization of angiogenesis during scarless and fibrotic fetal wound repair. Presented at the Experimental Biology Meeting. FASEB J 18(5) A941. TA Wilgus, TM Oberyszyn, VK Bergdall, AM Ferriera, and LA DiPietro. 2005. VEGF-associated angiogenesis promotes cutaneous scar tissue deposition. Presented at the Experimental Biology Meeting. FASEB J 19(4) A482. TA Wilgus, AM Matthies, KA Radek, and LA DiPietro. 2005. Epidermal keratinocytes express functional vascular endothelial growth factor receptor-1. Presented at the Society for Investigative Dermatology Meeting. J Invest Dermatol 124(4): A93. TA Wilgus, TM Oberyszyn, VK Bergdall, AM Ferreira, and LA DiPietro. 2005. Modulation of scar formation by vascular endothelial growth factor. Presented at the Wound Healing Society Meeting. Wound Rep Regen 13(2) A18. TA Wilgus, VK Bergdall, LA DiPietro, and TM Oberyszyn. 2005. The effects of hydrogen peroxide on fetal wound repair. Presented at the Wound Healing Society Meeting. Wound Rep Regen 13(2) A45. TA Wilgus, AM Ferreira, TM Oberyszyn, VK Bergdall, and LA DiPietro. 2005. Vascular endothelial growth factor modulates cutaneous scarring. Presented at the Gordon Research Conference on Tissue Repair and Regeneration. TA Wilgus and LA DiPietro. 2005. Non-endothelial effects of vascular endothelial growth factor: implications for wound repair. Presented at the Montagna Symposium on the Biology of Skin. J Invest Dermatol Symp Proceed, 2006, 11(1) 143. AM Ferreira, DE Faunce, TA Wilgus, R Fresco, JA McNulty, and LA DiPietro. 2006. Modulation of wound scar formation by monocyte chemoattractant protein-1 (MCP-1). Presented at the Experimental Biology Meeting. FASEB J 20(5) A872. LA DiPietro, TA Wilgus, and AM Szpaderska. 2006. Angiogenesis in healing wounds: why less may be more. Presented at the Experimental Biology Meeting. FASEB J 20(5) A871. TA Wilgus. 2006. Fetal wound healing. Presented at the Symposium on Advanced Wound Care. TA Wilgus, TM Oberyszyn, LA DiPietro, and DF Kusewitt. 2007. The role of epithelial vascular endothelial growth factor receptor-1 (VEGFR-1) in skin carcinogenesis. Presented at the Am. Assoc. for Cancer Res. Meeting. Proc Am Assoc Cancer Res 48: 625.

Source: https://heartlung.osu.edu/SiteCollectionDocuments/CVs/WilgusCV.pdf