The 59th annual Montagna Symposium on the Biology of Skin presents
POSTERS Ewout M. Baerveldt1,2, Armanda J. Onderdijk1,2, Chris Wohn2, Marius Kant1,2, Eddy F. Florencia1,2, Jon D. Laman2, H. Bing Thio1, Johann E. Gudjonsson2, Errol P. Prens1,2 1Departments of Dermatology and 2Immunology, Erasmus MC, Rotterdam, The Netherlands 3Department of Dermatology, University of Michigan, Ann Arbor, MI Nerve growth factor regulation by Th17/IL23 in murine psoriasis-like model and human uninvolved psoriatic skin Paulo R. Bargo, Melissa Chu, Inseok Seo, Guojin Zhang, Nikiforos Kollias Johnson & Johnson Consumer Companies In vivo assessment of the evolution of UV-induced immune responses in human skin Elhabib Benlhabib1, M. K. Hordinsky1, A. C. Junqueira Bertin1, I. G. Panoutsopoulou1,3, G. Wendelschafer-Crabb3, W. R. Kennedy3, G. L. Wilcox1,2 Departments of 1Dermatology, 2Neuroscience and 3Neurology, University of Minnesota, Minneapolis, MN Long-term exposure to sun (UVB) induces skin cancer, premature skin aging and cutaneous immunosuppression Jamie J. Bernard, Richard L. Gallo Division of Dermatology, University of California, San Diego Cox-2 activity is required for enhanced antimicrobial peptide expression and bacteriocidal activity in human keratinocytes Ferda Cevikbas1, Xidao Wang2, Akihiko Ikoma1, Victoria Fong1, Stephan Seeliger3, Stacey R. Dillon4, Michael Fischer5, Peter Reeh 5, Attila Antal6, Bernhard Homey6, Allan Basbaum2, Martin Steinhoff1 Departments of 1Dermatology, Surgery and 2Anatomy, University of California, San Francisco, CA 3Department of Pediatrics, University of Goettingen, Germany 4ZymoGenetics, Inc., Seattle, WA 5Department of Physiology, University of Erlangen, Germany 6Department of Dermatology, University of Duesseldorf, Germany Interleukin-31 induces scratching in mice via IL-31RA/OSMRβ activation in untreated as well as oxazolone-sensitized skin Melanie C. Dispenza, Amanda M. Nelson, Kathryn L. Gilliland, Zhaoyuan Cong, Amy L. Longanecker, LeRoy J. Tanner, Diane M. Thiboutot Dept of Dermatology, Pennsylvania State University College of Medicine, Hershey, PA Immune modulation by isotretinoin in vivo . José R. Fernández, Xuyan Feng, Eduardo Pérez, Karl Rouzard, Arnold González, Seung-Yub Lee, Michael Voronkov, Gopal Sarngadharan, Joel S. Gordon, Maxwell Stock Signum Biosciences, Inc., Monmouth Junction, NJ Isoprenylcysteine (IPC) analogs, G-protein CAAX tail mimics, are a new class of topical anti-inflammatories with a low potential for adverse effects Akihiko Ikoma1, Ferda Cevikbas1,2, Victoria Fong1, Eric Camerer3, Shaun R. Coughlin3, Martin Steinhoff1,2 1Departments of Dermatology, 2Surgery and 3 Cardiovascular Research Institute, University of California, San Francisco, CA 4 Cardiovascular Research Center, INSERM, Paris, France Conditional over-expression of protease-activated receptor-2 in murine keratinocytes results in pruritic dermatitis with increased nerve growth factor release in vivo Zhixing Wang1, Jay Kirkwood1, Fred Stevens1, Mark Leid1,2, Gitali Ganguli-Indra1, Arup Indra1,2,3,4 1Department of Pharmaceutical Sciences, College of Pharmacy, 2Molecular and Cellular Biology Program, 3Environmental Health Science Center, Oregon State University, Corvallis, OR 4Department of Dermatology, Oregon Health and Science University, Portland, OR Transcription factor Ctip2/ Bcl11b regulates skin lipid metabolism and plays a crucial role in formation of epidermal permeability barrier (EPB)
Rosane Teles1, Andrew Chung1, Saeid Ghavami2, Huiying Li3, Xinmin Li4, Delphine J.Lee1 1Division of Dermatology, Dept of Medicine, 2Dept of Pathology & Laboratory Medicine, David Geffen School of Medicine and 3Crump Institute for Molecular Imaging, Dept of Molecular and Medical Pharmacology, UCLA-DOE Institute for Genomics and Proteomics, University of California, Los Angeles, CA 4Dept of Physiology, Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada Gene expression profiles at the site of disease reveal a role for S100A8 /A9 in promoting melanocyte loss in vitiligo
Kimberly R. Lumsden1, Amanda M. Nelson2, Melanie Dispenza3, Kathryn L. Gilliland2, Zhaoyuan Cong2, Diane M. Thiboutot1,2 1Jake Gittlen Cancer Research Foundation, Departments of 2Dermatology and 3Molecular and Cellular Physiology, Pennsylvania State University, College of Medicine, Hershey, PA NGAL expression is induced by P. acnes and isotretinoin in sebocytes and increased on the skin surface of acne patients and patients receiving isotretinoin Heather McGee, Richard Flavell, Valerie Horsley Departments of Immunobiology, and Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT Role of Interleukin-22 in acute skin wounding Jun Muto1, Lionel Breton2, Richard L. Gallo1 1Division of Dermatology, University of California, San Diego 2L’Oréal Recherche, Clichy, France A C-xylopyranoside derivative stimulates dermatan sulfate synthesis and promotes keratinocyte migration Amanda M. Nelson, Zhaoyuan Cong, Kathryn L. Gilliland, Diane M. Thiboutot Jake Gittlen Cancer Research Foundation and Department of Dermatology, Pennsylvania State University College of Medicine, Hershey, PA On the TRAIL to isotretinoin’s mechanism of action in acne treatment Stephen M. Ostrowski 1,2, Abdelmadjid Belkadi1, Candace M. Matheny2, Doina Diaconu2, Nicole L. Ward 1,2,3 Departments of 1Neurosciences and 2Dermatology, Case Western Reserve University, Cleveland, OH; 3The Murdough Family Center for Psoriasis, University Hospitals, Case Medical Center, Cleveland, OH Nerve-derived substance P (SP) and calcitonin gene related peptide (CGRP) sustain CD11c+ and CD4+ cutaneous cell infiltration and contribute to acanthosis in the KC-Tie2 mouse model of psoriasis
So Yeon Paek1, Fumi Miyagawa1, Hong Zhang1, Jay Linton1, R. Mark Simpson2, Stephen I. Katz1 1Dermatology Branch, CCR, NCI, NIH, Bethesda, MD 2Molecular Pathology Unit, Laboratory of Cancer Biology & Genetics, NIH, Bethesda, MD Peptide protection of the pinna: how small molecules rescue ear phenotype in a mouse model of autoimmunity Ioanna Panoutsopoulou1, George L. Wilcox1,3,4, Gwen Wendelschafer-Crabb2, William R. Kennedy2, Maria K. Hordinsky1 Departments of 1Dermatology, 2Neurology, 3Neuroscience and 4Pharmacology, University of Minnesota, Minneapolis, MN Suction skin blister confocal analysis of nerve fiber and Langerhans cell expression in psoriasis and normal human skin
Amala Soumyanath1, Julia Sonka2, Kevin Phillips3,4, Steven Jacques3,4, Philippe Thuillier2 Departments of 1Neurology, 2Public Health and Preventive Medicine, 3Biomedical Engineering and 4Dermatology, Oregon Health and Science University, Portland, OR Melanocytic responses to piperine, a small molecule from nature Ronald Wolf1,5, Francesca Mascia1, Alif Dharamsi1, O.M. Zack Howard2, Christophe Cataisson1, Val Bliskovski1, Jason Winston1, Lionel Feigenbaum4, Ulrike Lichti1,Thomas Ruzicka5,Triantafyllos Chavakis3, Stuart H. Yuspa1 1Laboratory of Cancer Biology and Genetics, 3Experimental Immunology Branch, CCR, NCI, NIH, Bethesda, MD 2Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, CCR, NCI, NIH, Frederick, MD 4 Laboratory Animal Sciences Program, SAIC, Frederick, MD 5Department of Dermatology, Ludwig Maximilian University, Munich, Germany Small S100 molecules with cutaneous antimicrobial activity prime skin for inflammation: A mouse model for psoriasis susceptibility
Basic, uncomplicated infection with Borrelia burgdorferi-not too ill, respond readily to antibioticsDisseminated, symptomatic disease- usually present longer, and may Need higher doses, longer duration, and also may need IV treatmentsNeed complex antibiotic regimens of long durationChronic Lyme- Patients ill for > I year, with many complications possible:Immune deficiencies (the beginnings
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