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SCI期刊論文
Chen BW, Chao CH, Su JH, Wen ZH, Sung PJ, Sheu JH. Anti-inflammatory eunicellin-based
diterpenoids from the cultured soft coral Klyxum simplex. Bioorganic Medicinal Chemistry
2010;8:2363-2366. (IF=3.075 subject categories Chemistry, medicinal 12/55)
Cheng SY, Chuang CT, Wen ZH, Wang SK, Chiou SF, Hsu CH, Dai CF, Duh CY. Bioactive
norditerpenoids from the soft coral Sinularia gyrosa. Bioorganic Medicinal Chemistry 2010 in
pressed (IF=3.075 subject categories Chemistry, medicinal 12/55)
Lu Y, Su JH, Huang CY, Liu YC, Kuo YH, Wen ZH, Hsu CH, Sheu JH. Cembranoids from the
soft corals Sinularia granosa and Sinularia querciformis. Chemical & Pharmaceutical
Bulletin 2010;58:464-466. (IF=1.623; subject categories Chemistry, multidisciplinary 48/125)
Cheng SY, Lin EH, Wen ZH#, Chiang MY, Duh CY#. Two new verticillane-type diterpenoids
from the Formosan soft coral Cespitularia hypotentaculata. Chemical & Pharmaceutical
Bulletin 2010 accept (IF=1.623; subject categories Chemistry, multidisciplinary 48/125)
#correspondent author (equally contributed to this paper)
Cheng SY, Lin EH, Huang JS, Wen ZH, Duh CY. Ylangene-type and nardosinane-type
sesquiterpenoids from the soft coral Lemnalia flava and Paralemnalia thyrsoides. Chemical &
Pharmaceutical Bulletin 2010;58:381-385. (IF=1.623; subject categories Chemistry,
multidisciplinary 48/125)
Cheng SY, Huang KJ, Wang SK, Wen ZH, Chen PW, Duh CY. Antiviral and
anti-inflammatory metabolites from the soft coral Sinularia capillosa. Journal of Natural
Products 2010 in press (IF=2.843 subject categories Chemistry, applied 4/60) PMID:
20155971
Lin WY, Su JH, Lu Y, Wen ZH, Dai CF, Kuo YH, Sheu JH. Cytotoxic and anti-inflammatory
cembranoids from the Dongsha Atoll soft coral Sarcophyton crassocaule. Bioorganic
Medicinal Chemistry 2010;18:1936-1941 (IF=3.075 subject categories Chemistry, medicinal
12/55)
Su JH, Chiang MY, Wen ZH, Dai CF, Hsu CH, Sheu JH. Sesquiterpenoids from the Formosan
soft coral Sinularia leptoclados. Chemical & Pharmaceutical Bulletin 2010;58:250-253.
(IF=1.623; subject categories Chemistry, multidisciplinary 48/125)
Chen WF, Sung CS, Jean YH, Su TM, Wang HC, Ho JT, Huang SY, Lin CS, Wen ZH*.
Suppressive effects of intrathecal granulocyte colony-stimulating factor on excessive release of
excitatory amino acids in the spinal cerebrospinal fluid of rats with cord ischemia: Role of
glutamate transporters Neuroscience 2010;165:1217-1232. (IF=3.556; subject categories
Neuroscience 66/219) *correspondent author
10. Wu SC, Horng JL, Liu ST, Liu ST, Hwang PP, Wen ZH, Lin CS, Lin LY.
Ammonium-Dependent Sodium Uptake in Mitochondrion-Rich Cells of Medaka (Oryzias
latipes) Larvae. American Journal of Physiology-Cell Physiology 2010;298:C237-250.
(IF=4.23 subject categories Physiology 9/74)
11. Cheng SY, Wang SK, Wen ZH, Dai CF, Duh CY. Three new eudesmanoids from the Formosan
soft coral Nephthea erecta. Journal of Asian Natural Prodcuts Research 2009;11:967-973.
12. Chakraborty C, Hsu CH, Wen ZH, Lin CS. Anticancer drugs discovery and development from
marine organism. Current Topics in Medicinal Chemistry 2009;9:1536-1545. (IF=4.268;
subject categories Chemistry, Medicinal 4/40)
13. Cheng SY, Huang KJ, Wang SK, Wen ZH, Hsu CH, Dai CF, Duh CY. New terpenoids from
the soft corals Sinularia capillosa and Nephthea chabroli. Organic Letters
2009;11:4830-4833. (IF=5.128; subject categories Chemistry, Organic 4/55)
14. Liu GS, Huang HT, Lin CJ, Shi JY, Liu LF, Tseng, RT, Weng WT, Lam HC, Wen ZH, Cheng
TL, Hsu KS, Tai MH. Prophylactic proopiomelanocortin expression alleviates
capsaicin-induced neurogenic inflammation in rat trachea. Shock 2009;32:645-50.
15. Tseng YJ, Wen ZH, Dai CF, Chiang MY, Sheu JH. Nanolobatolide, a new C18 metabolite
form the Formosan soft coral Sinularia nanolobata. Organic Letters 2009;11:5030-5032.
(IF=5.128; subject categories Chemistry, Organic 4/55) 16. Jean YH, Chen WF, Sung CS, Duh CY, Huang SY, Lin CS, Tai MH, Tzeng SF, Wen ZH*.
Capnellene, a natural marine compound derived from soft coral, attenuates chronic constriction
injury-induced neuropathic pain in rats. British Journal of Pharmacology 2009;158:713-725.
(IF=4.902 subject categories Pharmacology & Pharmacy 18/216) *correspondent author
17. Horng JL, Hwang PP, Shih TT, Wen ZH, Lin CS, Lin LY. Chloride transport in
mitochondrion-rich cells of euryhaline Tilapia (Oreochromis mossambicus). American
Journal of Physiology-Cell Physiology 2009;297;C845-854. (IF=4.23 subject categories
Physiology 9/74)
18. Chakraborty C, Hsu CH, Wen ZH, Duh CY, Lin CS. Drug discovery from marine resources.
Current Science 2009;97:292-293. (IF=0.774 subject categories Multidisciplinary Science
22/42)
19. Chakraborty C, Hsu CH, Wen ZH, Lin CS. Recent advances of fluorescent technologies for
drug discovery development. Current Pharmaceutical Design 2009;15:3552-3570. (IF=4.399
subject categories Pharmacology & Pharmacy 26/216)
20. Wong CS, Wu GJ, Chen WF, Jean YH, Hung CH, Lin CS, Huang SY, Wen ZH*.
N-methyl-D-aspartate receptor antagonist D-AP5 prevents pertussis toxin-induced alterations in
rat spinal cords by inhibiting increase in concentrations of spinal CSF excitatory amino acids
and downregulation of glutamate transporters. Brain Research Bulletin 2009;80:69-74.
*correspondent author (IF=2.281; subject categories Neuroscience 135/219)
21. Lee CH#, Wen ZH#, Chang YC, Huang SY, Tang CC, Chen WF, Hsieh SP, Jean YH.
Intra-articular magnesium sulfate (MgSO4) reduces experimental osteoarthritis and nociception:
association with attenuation of N-methdyl-D-sapartate (NMDA) receptor subunit 1
phosphorylation and apoptosis in rat chondrocytes. Osteoarthritis & Cartilage
2009;17:1485-1493. (IF=4.082; subject categories Orthopedics 1/49) # equally contributed to
this paper
----------------------------------------------2009.07.31-----------------------------------------
22. Liu GS, Shi JY, Lai CL, Hong YR, Shin SJ, Huang HT, Lam HC, Wen ZH, Hsu KS, Howng
SL, Tai MH. Peripheral gene transfer of glial-derived neurotrophic factor ameliorates the
neuropathic deficits in diabetic rats. Human Gene Therapy 2009;20:715-727. (IF=4.101
subject categories Biotechnology and applied Microbiology 23/144)
23. Wu SL, Su JH, Wen ZH, Hsu CH, Chen BW, Dai CF, Kuo YH, Sheu JH. Simplexins A-I,
eunicellin-based diterpenoids from the soft coral Klyxum simplex. Journal of Natural
Products 2009;72:994-1000. (IF=2.843 subject categories Chemistry, applied 4/60)
24. Cheng SY, Huang YC, Wen ZH, Hsu CH, Wang SK, Dai CF, Duh CY. New 19-oxygenated
and 4-methylated steroids from the Formosa soft coral Nephthea chabroli. Steroids
2009;74:543-547. (IF=2.588, subject categories biochemistry & molecular biology
140/276;cited:0)
25. Cheng SY, Wen ZH, Wang SK, Chiou SF, Hsu CH, Dai CF, Duh CY. Anti-inflammatory
cembranolides from soft coral Lobophytum durum. Bioorganic & Medicinal Chemistry
2009;17:3763-3769. (IF=3.075 subject categories Chemistry, medicinal 12/55;cited:0)
26. Chakraborty C, Hsu CH, Wen ZH, Lin CS, Agoramoorthy G. Zebrafish: a complete animal
model for in vivo drug discovery and development. Current Drug Metabolism
2009;10:166-124. (IF=4.350; subject categories Pharmacology & Pharmacy 29/216;cited:0)
27. Cheng SY, Huang YC, Wen ZH, Chiou SF, Hsu CH, Wang SK, Dai CF, Chiang MY, Duh CY.
Novel sesquiterpenes and norergosterol from the soft corals Nephthea erecta and N. chabroli.
Tetrahedron Letters 2009;50:802-806. (IF：2.538, subject categories chemistry, organic
Ranking: 21/55 ;cited:0)
28. Chakraborty C, Sarkar B, Hsu CH, Wen ZH, Lin CS, Shieh PC. Future prospects of
nanoparticles on brain targeted drug delivery. Journal of Neuro-oncology. 2009;10:116-124.
(IF=2.323; subject categories clinical neurology 70/156;cited:0)
29. Cheng SY, Wen ZH, Chiou SF, Tsai CW, Wang SK, Hsu CH, Dai CF, Chiang MY, Wang
WH, Duh CY. Ceramide and Cerebrosides from the Octocoral Sarcophyton ehrenbergi.
Journal of Natural Products 2009;72:465-468. (IF=2.843 subject categories Chemistry,
applied 4/60;cited:0)
30. Cheng SY, Wen ZH, Wang SK, Chiou SF, Hsu CH, Dai CF, Chiang MY, Duh CY.
Unprecedented hemiketal cembranolides with anti-inflammatory activity from the soft coral
Lobophytum durum. Journal of Natural Products 2009;72:152-155. (IF=2.843 subject
categories Chemistry, applied 4/60;cited:0)
31. Cheng SY, Wen ZH, Wang SK, Chiang MY, El-Gamal AAH, Dai CH, Duh CY. Revision of
the absoulte configuration at C (23) hydroxyl of lanostanoids and isolation secondary
metabolites from Formosan soft coral Nephthea erecta. Chemistry & Biodiversity
2009;6:86-95. (IF=1.659 subject categories chemistry, multidisciplinary 47/125;cited:0)
32. Su JH, Lo CL, Lu Y, Wen ZH, Huang CY, Dai CF, Sheu JH. Anti-inflammatory
polyoxygenated steroids from the soft coral Sinularia sp. Bulletin of the Chemical Society of
Japan 2008;81:1616-1620. (IF=1.677; subject categories Chemistry, multidisciplinary
45/125;cited:0)
33. Chao CH, Wen ZH, Wu YC, Yeh HC, Sheu JH. Cytotoxic and anti-inflammatory cembranoids
from the Soft Coral Lobophytum crassum. Journal of Natural Products 2008; 71: 1819-1824.
(IF=2.843 subject categories Chemistry, applied 4/60;cited:0)
34. Lu Y, Huang CY, Lin YF, Wen ZH, Su JH, Kuo YH, Chiang MY, Sheu JH. Anti-inflammatory
cembranoids from the soft corals Sinularia querciformis and Sinularia granosa. Journal of
Natural Products 2008; 71:1754-1959. (IF=2.843 subject categories Chemistry, applied
4/60;cited:1)
35. Wu GJ, Chen WF, Sung CS, Jean YH, Hung CH, Chen FA, Hsieh MH, Wen ZH*. Isoflurane
attenuates dynorphin-induced cytotoxicity and downregulation of Bcl-2 expression in
differentiated neuroblastoma SH-SY5Y cells. Acta Anaesthesiologica Scandinavica
2009;53:55-60. (IF = 1.953, subject categories Anesthesiology 11/22; cited:0) *correspondent
author
36. Cheng SY, Wen ZH, Chiou SF, Hsu CH, Wang SK, Dai CF, Chiang MY, Duh CY.
Durumolides A-E, anti-inflammatory and antibacterial cembranolides from the soft coral
Lobophytum durum. Tetrahedron 2008;64:9698-9704.(IF=2.897; subject categories Chemistry,
organic 16/55;cited:5)
37. Chao CH, Wen ZH, Su JH, Chen IM, Huang HC, Dai CF, Sheu JH. Further study on
anti-inflammatory oxygenated steroids form the octocoral Dendronephthya griffini. Steroids
2008;73:1353-8 (IF=2.588, subject categories biochemistry & molecular biology 140/276;
cited:0)
38. Huang YC, Wen ZH, Wang SK, Hsu CH, Duh CY. New anti-inflammatory 4-methylated
steroids from the Formosan soft coral Nephthea chabroll. Steroids 2008;73:1181-1186.
(IF=2.588, subject categories biochemistry & molecular biology 140/276;cited:2)
39. Jean YH#, Wen ZH#, Chang YC, Hsieh SP, Lin JD, Tang CC, Chen WF, Chou AK, Wong CS.
Increase in excitatory amino acid concentration and transporters expression in osteoarthritic
knees of anterior cruciate ligament transected rabbits. Osteoarthritis & Cartilage
2008;16:1442-1449. (IF=4.082; subject categories Orthopedics 1/49;cited:0) # equally
contributed to this paper
40. Ahmed AF, Tai SH, Wen ZH, Su JH, Wu YC, Hu WP, Sheu JH. A C-3 methylated
isocembranoid and 10-oxocembranoids from a formosan soft coral, Sinularia grandilobata.
Journal of Natural Product 2008;71:946-951. (IF=2.843 subject categories Chemistry,
applied 4/60;cited:0)
41. Chen SD, Wen ZH, Chang WK, Chan KH, Tsou MT, Sung CS, Tang GJ. Acute effect of
methylprednisolone on the brain in a rat model of allergic asthma. Neuroscience Letters
2008;440:57-91. (IF=2.200, subject categories Neuroscience 139/219;cited:0)
42. Chang CH, Wen ZH, Wang SK, Duh CY. Capnellenes from the Formosan soft coral Capnella
imbricata. Journal of Natural Products 2008;71:619-621.(IF=2.843; subject categories
Chemistry, applied 4/60;cited:1)
43. Chen WF, Jean YH, Sung CS, Huang SY, Wu GJ. Ho JT, Su TM, Wen ZH*. Intrathecally
injected granulocyte colony-stimulating factor produced neuroprotective effects in spinal cord
ischemia via the mitogen-activated protein kinase and Akt pathways. Neuroscience
2008;153:31-43. (IF=3.556; subject categories Neuroscience 66/219;cited:0) *correspondent
author
44. Chao CH, Wen ZH, Chen IM, Su JH, Huang HC, Chiang MY, Sheu JH. Anti-inflammatory
steroids from the octocoral Dendronephthya griffini. Tetrahedron 2008;64:3554-3560.
(IF=2.897; subject categories Chemistry, organic 16/55;cited:1)
45. Chang CH, Wen ZH, Wang SK, Duh CY. New anti-inflammatory steroids from the Formosan
soft coral Clavularia viridis. Steroids 2008;73:562-567. (IF=2.588, subject categories
biochemistry & molecular biology 140/276;cited:0)
46. Ahmed AF, Wen ZH, Su JH, Hsieh YT, Wu YC, Hu WP, Sheu JH. Oxygenated cembranoids
from a Formosan soft coral Sinularia gibberosa. Journal of Natural Products
2008;71:179-185 (IF=2.843; subject categories Chemistry, applied 4/60;cited:3)
47. Yeh TT, Wen ZH, Lee HS, Lee CH, Yang Z, Jean YH, Wu SS, Nimni ME, Han B.
Intra-articular injection of collagenase induced experimental osteoarthritis of the lumbar facet
joint in rats. European Spine Journal 2008;17:734-742. (IF=2.396, subject categories
Orthopedics 8/49;cited:1)
48. Wen ZH, Wu GJ, Hsu LC, Chen WF, Chen JY, Shui HA, Chou AK, Wong CS.
N-Methyl-D-aspartate receptor antagonist MK-801 attenuates morphine tolerance and
associated glial fibrillary acid protein up-regulation: a proteomic approach. Acta
Anaesthesiologica Scandinavica 2008;52:499-508. (IF = 1.953, subject categories
Anesthesiology 11/22;cited:0)
49. Jean YH, Chen WF, Duh CY, Huang SY, Hsu CH, Lin CS, Sung CS, Chen IM, Wen ZH*.
Inducible nitric oxide synthase and cyclooxygenase-2 participate in anti-inflammatory and
analgesic effects of the natural marine compound lemnalol from Formosan soft coral Lemnalia
cervicorni. European Journal of Pharmacology 2008;578:323-331. (IF=2.787, subject
categories Pharmacology & Pharmacy 76/219;cited:0) *correspondent author
50. Wu GJ, Chen WF, Sung CS, Jean YH, Shih CM, Shyu CY, Wen ZH*. Preventive effects of
intrathecal methylprednisolone administration on spinal cord ischemia in rats: the role of
excitatory amino acid metabolizing systems. Neuroscience 2007;147:294-303. (IF=3.556;
subject categories Neuroscience 66/219; cited:5) *correspondent author
51. Yeh TT, Wu SS, Lee CH, Wen ZH, Lee HS, Yang Z, Nimni ME, Han B. The short-term
therapeutic effect of recombinant human bone morphogenetic protein-2 on
collagenase-induced lumbar facet joint osteoarthritis in rats. Osteoarthritis & Cartilage 2007;
15: 1357-1366. (IF=4.0823.793; subject categories Orthopedics 1/49; cited:0)
52. Behery FA, Naeem ZE, Maatooq GT, Amer MM, Wen ZH, Sheu JH, Ahmed AF.
Phenanthrenoids from Juncus acutus L., new natural lipopolysaccharide-inducible nitric oxide
synthase inhibitors. Chemical & Pharmaceutical Bulletin 2007;55:1264-1266. (IF=1.623;
subject categories Chemistry, multidisciplinary 48/125;cited:0)
53. Jean YH, Wen ZH, Chang YC, Hsieh SP, Tang CC, Wang YH, Wong CS. Intra-articular
injection of the cyclooxygenase-2 inhibitor parecoxib attenuates osteoarthritis progression in
anterior cruciate ligament-transected knee in rats: role of excitatory amino acids.
Osteoarthritis & Cartilage 2007;15:638-645 (IF=4.082.793; subject categories Orthopedics
1/49;cited:3)
54. Wu GJ*, Wen ZH*, Chen WF, Chang YC, Cherng CH, Wong CS. The effect of dexamethasone
on spinal glutamine synthetase and glutamate dehydrogenase expression in morphine-tolerant
rats. Anesthesia & Analgesia 2007;104:726-30 * equally contributed to this paper (IF=2.590;
subject categories Anesthesiology 6/22;cited:4)
55. Hsu CH, Wen ZH, Lin CS, Chakraborty C. The zebrafish model: use in studying cellular
mechanisms for a spectrum of clinical disease entities. Current Neurovascular Research
2007;4:111-20. (IF= 3.571; subject categories Clinical neurology, 28/156;cited:0)
56. Huang HC, Wen ZH, Chao CH, Ahmed AF, Chiang MY, Kuo YH, Hsu CH, Sheu JH. Novel
sesquiterpenoids from the Formosan soft coral Paralemnalia thyrsoides. Tetrahedron Letters
2006;47:8751-8755. (IF=2.538; subject categories Chemistry, organic 21/55;cited:9)
57. Ahmed AF, Hsieh YT, Wen ZH, Wu YC, Sheu JH. Polyoxygenated sterols from the Formosan
soft coral Sinularia gibberosa. Journal of Natural Products 2006;69:1275-1279. (IF=2.843;
subject categories Chemistry, applied 4/60;cited:13)
58. Jean YH, Wen ZH, Lee HS, Chang YC, Hsieh SP, Cherng CH, Wu CT, Wong CS. Hyaluronic
acid attenuates early osteoarthritis development in the anterior cruciate ligament-transected
knee: associated with excitatory amino acids release in the joint dialysate. Journal of
Orthopaedic Research 2006;24:1052-1061.(IF=2.963; subject categories Orthopedics 4/49;
cited:5)
59. Wu GJ, Wen ZH, Chang YC, Yang SN, Tao PL, Wong CS. Protein kinase C inhibitor
chelerythrine attenuates the morphine-induced excitatory amino acid release and reduction of
the antinociceptive effect of morphine in rats injected intrathecally with pertussis toxin. Life
Sciences 2006;78:1801-1807. (IF=2.583; subject categories Medicine, research &
experimental 33/82;cited:1)
以下個人單位非中山大學
60. Lin JA, Lee MS, Wu CT, Yeh CC, Lin SL, Wen ZH, Wong CS. Attenuation of morphine
tolerance by intrathecal gabapentin is associated with suppression of morphine-evoked
excitatory amino acid release in the rat spinal cord. Brain Research
2005;1054:167-173.(IF=2.494; subject categories Neuroscience 120/219;cited:13)
61. Sung CS, Wen ZH, Chang WK, Chan KH, Ho ST, Tsai SK, Chang YC, Wong CS. Inhibition
of p38 mitogen-activated protein kinase attenuates interleukin-1-induced thermal
hyperalgesia and inducible nitric oxide synthase expression in the spinal cord. Journal of
Neurochemistry. 2005;94:742-752. (IF=4.500; subject categories Neuroscience
40/219;cited:17)
62. Wen ZH, Wu GJ, Chang YC, Wang JJ, Wong CS. Dexamethasone modulates the
development of morphine tolerance and expression of glutamate transporters in rats.
Neuroscience 2005;133:807-817. (IF=3.556; subject categories Neuroscience 66/219;cited:17)
63. Jean YH, Wen ZH, Chang YC, Huang GS, Lee SH, Hsieh SP, Wong CS. Increased
concentration of neuro-excitatory amino acids in rat anterior cruciate ligament-transected knee
joint dialysates: a microdialysis study. Journal of Orthopaedic Research 2005;23:569-75.
(IF=2.437; subject categories Orthopedics 5/48;cited:5 )
64. Sung CS, Wen ZH, Chang WK, Ho ST, Tsai SH, Chang YC, Wong CS. Intrathecal
interleukin-1 beta administration induces thermal hyperalgesia by activating inducible nitric
oxide synthase expression in the rat spinal cord. Brain Research
2004;1015:145-153.(IF=2.494; subject categories Neuroscience 120/219;cited:31)
65. Wen ZH, Chang YC, Cherng CH, Wang JJ, Tao PL, Wong CS. Increasing of intrathecal CSF
excitatory amino acids concentration following morphine challenge in morphine-tolerant rats.
Brain Research 2004;959:253-259. (IF=2.494; subject categories Neuroscience
120/219;cited:16)
66. Wen ZH, Guo YW, Chang YC, Wong CS. D-2-amino-5-phosphonopentanoic acid inhibits
intrathecal pertussis toxin-induced thermal hyperalgesia and protein kinase Cgamma
up-regulation. Brain Research 2003;963:1-7. (IF=2.494; subject categories Neuroscience
120/219;cited:5)
67. Wen ZH, Yang LC, Wang JJ, Hsing CH, Chen JY, Chang YC, Wong CS. Intrathecal pertussis
toxin induces thermal hyperalgesia: involvement of excitatory and inhibitory amino acids.
Neuroscience 2003;116:871-878. (IF=3.556; subject categories Neuroscience 66/219;cited:14)
68. Lin CR, Wang CH, Wu P, Wen ZH, Buerkle H, Yang LC. Apraclonidine attenuates the
increases in spinal excitatory amino acid release in rats with adjuvant-induced inflammation. Anesthesia & Analgesia 2002;94:701-705.(IF=2.590; subject categories Anesthesiology
6/22;cited:4)
69. Wen ZH, Wong CS, Lin CR, Chou AK, Tan PH, Chang YC, Kao CH, Cheng TJ, Yang LC.
Changes in the levels of nitric oxide synthase and protein kinase C gamma following kainic
acid receptor activation in the rat spinal cord. Neuroscience Letters 2001;309:25-28.
(IF=2.200; subject categories Neuroscience 139/219;cited:4)
70. Ho YJ, Liu TM, Tai MY, Wen ZH, Chow SS, Tsai YF, Wong CS. Effect of olfactory
bulbectomy on NMDA receptor density in the rat brain: [3H]MK-801 binding assay. Brain
Research 2001;900:214-218. (IF=2.494; subject categories Neuroscience 120/219;cited:14)
1. Wen ZH, Tang CC, Chang YC, Huang SY, Hsieh SP, Lee CH, Huang GS, Ng HF, Neoh CA,
Hsieh CS, Chen WF, Jean YH. Glucosamine sulfate reduces experimental osteoarthritis and nociception in rats: association with changes of mitogen-activated protein kinase in chondrocytes. Osteoarthritis & Cartilage 2010 revision (IF=4.082; subject categories Orthopedics 1/49)
1.溫志宏、杜昌益、林全信、徐基新；Lemnalol applying for treating inflammation and pain 穗花珊瑚醇於發炎疼痛治療之應用(中華民國專利申請中 096114501) 2. 許 志 宏 、 趙 子 華 、 溫 志 宏 ； Sulfur-containing compound, method of preparation and pharmaceutical uses thereof 含 硫 化 合 物 其 製 造 方 法 及 其 醫 藥 上 之 應 用 ( 中 華 民 國 專 利096132313 申請中;美國、歐盟及日本專利申請中) 3.溫志宏、杜昌益、林宗諺、孫裕民、張晉祥、林全信；Compound and pharmaceutical composition thereof for treating neuropathic pain 用於治療神經病理性疼痛之刺冠珊瑚醇化合物及其醫藥組合(中華民國專利 096141098 申請中) 4 . 許 綸 中 、 溫 志 宏 、 李 冠 諭 ; U s e o f v a n i l l y a l c o h o l f o r t h e t r e a t m e n t o f P a r k i n s o n ’s d i s e a s e 香 莢 蘭 醇 在 製 備 治 療 巴 金 森 氏 症 之 藥 物 的 用 途 ( 中 華 民 國9 7 11 3 3 9 6 及 美 國 專 利 申 請 中 ) 5. 許志宏、溫志宏、王維賢、樊同雲、林彥佑、林妤芳、盧詣; Isolating Method from Cultured Sinularia flexibilis and Ya-s 11 for Use in Treatment of Rheumatoid Arthritis 自養殖型柔軟指形軟珊瑚分離天然物 Ya-s 11 方法及其用於治療類風濕性關節炎(中華民國專利送審中 097148684) 6. 溫志宏、許志宏、樊同雲、王維賢、林彥佑; 11-Dehydrosinulariolide Isolating Method from Cultured Sinularia flexibilis and the Application in Treatment of Neurodegenerative Diseases in Treatment of Neurodegenerative Diseases 自 養 殖 型 柔 軟 指 形 軟 珊 瑚 分 離 天 然 物11-Dehydrosinulariolide 方法及其用於治療神經退化性疾病(中華民國專利申請中 098124526) 7. 許志宏、溫志宏、樊同雲、王維賢、林彥佑; Dihydrosinularin Isolating Method from Cultured Sinularia flexibilis and the Application in Treatment of Neurodegenerative Diseases 自養殖型柔軟指形軟珊瑚分離天然物 dihydrosinularin 方法及其用於治療神經退化性疾病(中華民國專利申請中 098124525) 8. 溫志宏、吳柏賢、劉文生、張富信、陳琮崴; Fish body image analysis for use in the screening
of a candidate as a skin whitening agent and applications of the same 用於篩選一作為一皮膚美白
劑之候選物的魚體影像分析系統及其應用(中華民國專利申請中 098137923)
9.王惠民、陳中一、溫志宏; Composition for inhibiting melanogenesis and use thereof 抑制皮膚
黑色素沉著之組合物及其用途(中華民國專利申請中 099105580)

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班馬魚數值化分析活體美白活性 亞比多生技發展公司 非 SCI
1. Wen ZH, Chang YC, Wong CS. Implication of intrathecal pertussis toxin animal model on the
cellular mechanisms of neuropathic pain syndrome. Act. Anaesthesiol. Sin .
2003;41:187-196.(國科會優良期刊)
2. Lin SC, Hsieh SP, Wen ZH, Tu CH, Hung CH, Tang CC, Jean YH. The effect of platelet gels on
lumbar intertransverse process spinal fusion in a rabbit model. Formos J Surg 2008;41:7-14.
(被選為當年度最優秀論文)
3. Sarkar BK, Zen W, Ding S, Hsu CH, Wen ZH, Ling CS, Carkraborty C. Micro-magnetic
resonance image (m-MRI) study on the sepsis effected eyeball of zebrafish. Nature Precedings
posted 21 Dec 2008.


研討會論文
1.
Wen ZH, Chang YC, Wong CS. Mechanism of neuropathic pain syndrome: effect of pertussis
toxin. The 2000 annual meeting of Society of Anesthesiologists of Republic of China at
National Taiwan University, Taipei, from September 16 to 17.
Wen ZH, Chang YC, Wong CS. The effect of pertussis toxin on the cerebrospinal fluid
nociceptive neuromodulators in a rat neuropathic pain model. 16th Biomedical Sciences Annual
Meeting of ROC in Taipei, March 24-25, 2001.
Wen ZH, Guo YW, Chang YC, Ho ST, Wong CS. Intrathecal pertussis toxin induced-thermal
hyperalgesia: involvement of NMDA-PKC system. 10th World Congress on Pain, San Diego,
August 17-22, 2002.
Wong CS, Wen ZH, Chang YC. Intrathecal dexamethasone attenuated morphine
antinociceptive tolerance. 10th World Congress on Pain, San Diego, USA, August 17-22, 2002.
Wen ZH, Guo YW, Chang YC, Ho ST, Wong CS. Intrathecal pertussis toxin induced-thermal
hyperalgesia: involvement of NMDA-PKC  system. The 2002 annual meeting of Society of
Anesthesiologists of Republic of China at National Taiwan University, Taipei, from September
16 to 17.
Wong CS, Wen ZH, Chang YC. Intrathecal dexamethasone attenuated morphine
antinociceptive tolerance. The 2002 annual meeting of Society of Anesthesiologists of
Republic of China at National Taiwan University, Taipei, from September 16 to 17.
Wen ZH, Chang YC, Cherng CC, Wong CS. Increasing of CSF excitatory amino acids release
by morphine challenge in morphine tolerant rats. The year 2003 annual meeting of Chinese
Association for the Study of Pain in Taipei, March 15-16, 2003.
Wen ZH, Chang YC, Cherng CC, Wong CS. Establishment of a microdialysis animal model
for the study of spinal cord ischemia. The year 2003 annual meeting of Chinese Association for
the Study of Pain in Taipei, March 15-16, 2003.
Jean YH, Wen ZH, Chang YC, Chen YC, Wong CS. Role of excitatory amino acids and
PGE2 in early osteoarthritis of knee joint in rat: a microdialysis study. The year 2003 annual
meeting of Chinese Association for the Study of Pain in Taipei, March 15-16, 2003.
10. Wen ZH, Chang YC, Chen YC, Wong CS. Increasing of CSF excitatory amino acids release
by morphine challenge in morphine tolerant rats. 18th Biomedical Sciences Annual Meeting of ROC in Taipei, March 22-23, 2003. 11. Wen ZH, Chang YC, Wong CS. The relationship between spinal excitatory amino acids level
and neurological function in spinal cord ischemia: establish a spinal cord ischemia-microdialysis animal model. 18th Biomedical Sciences Annual Meeting of ROC in Taipei, March 22-23, 2003. 12. Jean YH, Wen ZH, Chang YC, Chen YC, Wong CS. Role of excitatory amino acids in early
osteoarthritis of knee joint in rats: a microdialysis study. 18th Biomedical Sciences Annual Meeting of ROC in Taipei, March 22-23, 2003. 13. Sung CS, Wen ZH, Chang WK, Tsai SK, Chang YC, Wong CS. Intrathecal injection of
interleukin-1 induces thermal hyperalgesia and inducible nitric oxide synthase expression in the rat spinal cord. The 2003 annual meeting of Society of Anesthesiologists of Republic of China at Chi-Mei medical center, Tainan, from September 19 to 21. 14. Jean YH, Wen ZH, Chang YC, Chen YC, Wong CS. Role of excitatory amino acids , nitric
oxide and PGE2 in early osteoarthritis of knee joint. 3rd Annual Meeting of Pacific Asian Society of Minimally Invasive Spine, Taipei, October 24-25, 2003. 15. Wen ZH, Chang YC, Chen YC, Wong CS. The Effect of Excitatory Amino Acids and PKC
on the PTX-induced Neuropathic Pain: A Possible Role of Glutamate Transporters. 19th Biomedical Sciences Annual Meeting of ROC in Taipei, Apr 22-23, 2004. 16. Sung CS, Wen ZH, Chang YC, Wong CS. Intrathecal interleukin-1 administration induces
thermal hyperalgesia and inducible nitric oxide synthase expression in the rat spinal cord. 19th Biomedical Sciences Annual Meeting of ROC in Taipei, Apr 22-23, 2004. 17. Wen ZH, Chang YC, Wong CS. The Effect of Excitatory Amino Acids and PKC on the
PTX-induced Neuropathic Pain: A Possible Role of Glutamate Transporters. The year 2004 annual meeting of Chinese Association for the Study of Pain in Taichung, April 10-11, 2004. 18. Wen ZH, Chang YC, Wong CS. Dexamethasone restores the antinociceptive effect of
morphine and the associated increase in intrathecal CSF excitatory amino acid concentrations following morphine challenge in morphine-tolerant rats: the role of glutamate transporters. The year 2004 annual meeting of Chinese Association for the Study of Pain in Taichung, April 10-11, 2004. 19. Sung CS, Wen ZH, Chang YC, Wong CS. Intrathecal interleukin-1 administration induces
thermal hyperalgesia and inducible nitric oxide synthase expression in the rat spinal cord. The year 2004 annual meeting of Chinese Association for the Study of Pain in Taichung, April 10-11, 2004. 20. Wen ZH, Wu GJ, Chang YC, Wong CS. NMDA Receptor Antagonist MK-801 Attenuates
Morphine Tolerance and Associated Glial Marker Glial Fibrillary Acid Protein Up-gulation: a proteomics approach. The 2004 annual meeting of Society of Anesthesiologists of Taiwan at Chang Gung Memorial Hospital, Taoyun, from September 25 to 26.(壁報比賽第一名) 21. Sung CS, Wen ZH, Chan KH, Tsai SK, Chang YC, Wong CS. Activation of spinal p38
mitogen-activated protein kinase is crucial for intrathecal interleukin-1-induced thermal hyperalgesia and inducible nitric oxide synthase expression. The 2004 annual meeting of Society of Anesthesiologists of Taiwan at Chang Gung Memorial Hospital, Taoyun, from September 25 to 26. 22. Wu GJ, Hsu LT, Chang YC, Wong CS, Wen ZH. Proteomic evidence for spinal glia activation
in the development of chronic constrictive injury induced neuropathic pain. 20th Biomedical Sciences Annual Meeting of ROC in Taipei, Mar 26-27, 2005. 23. Chen KH, Chang WK, Lai YL, Chang YC, Sung CS, Wen ZH. Intrathecal dexamethasone
suppresses experimental autoimmune encephalomyelitis: implication for the role of excitatory amino acid systems in the development of multiple sclerosis. 20th Biomedical Sciences Annual Meeting of ROC in Taipei, Mar 26-27, 2005. 以下個人單位為中山大學
24. Wen ZH, Sung CS, Chen WF, Chang YC, Huang SY, Tu CM, Wei YC, Duh CY.
Anti-inflammatory and analgesic activity of marine nature compound-Lemnalol of Formosan soft coral Lemnalia Cervicorni. The year 2006 annual meeting of Chinese Association for the Study of Pain in Kaohsiung, Mar 18-19, 2006. 25. Wu GJ, Chen WF, Sung CS, Shih CM, Shyu CY, Wen ZH. Preventive effects of intrathecal
methylprednisolone on spinal cord ischemia in rats: the role of excitatory amino acid metabolizing systems. The 2006 annual meeting of Society of Anesthesiologists of Taiwan at National Cheng Kung University Hospital, Tainan, from September 24 to 25. 26. Wu GJ, Chen WF, Sung CS, Shih CM, Shyu CY, Wen ZH. Preventive effects of intrathecal
methylprednisolone on spinal cord ischemia in rats: the role of excitatory amino acid metabolizing systems. The 2006 International Symposium on Stroke Research (ISSR) of Taiwan at Taipei Medical University, from Nov 5-4. 27. Chen WF, Jean HY, Sung CS, Wu GJ, Huang SY, Cheng YR, Wen ZH. Intrathecally injected
granulocyte colony stimulating factor produced neuroprotective in spinal cord ischemia via mitogen-activated kinase and Akt pathway. The 23th Joint Annual Conference of Biomedical Science, Taipei, Mar 29-30, 2007. 28. Jean YH, Chen WF, Tsai FN, Chen YW, Chang TW, Wu CL, Wen ZH. Increased in glutamate
and aspartate transporter expression in experimental osteoarthritis knees in rabbits. The 23th Joint Annual Conference of Biomedical Science, Mar 29-30, Taipei, 2008. 29. Huang SY, Wen ZH. Establishment of a novel in vivo inflammatory zebrafish animal model.
The 23th Joint Annual Conference of Biomedical Science, Mar 29-30, Taipei, 2008. 30. Huang TY, Chen WF, Jean YH, Sung CS, Huang SY, Tsai FN, Wen ZH. Neuroprotective
effect of dihydrosinularin, a marine-derived compound obtained from the soft coral Sinularia querciformis, on 6-hydroxydopamine-induced death in human neuroblastoma cells. The 24th Joint Annual Conference of Biomedical Science, Taipei, Mar 21-22, 2009. 31. Lin YY, Sheu JH, Jean YH, Sung CS, Huang SY, Sun YM, Chang TW, Wen ZH. Therapeutic
effects of the marine natural product 11-epi-sinulariolide acetate on rats with adjuvant-induced arthritis. The 24th Joint Annual Conference of Biomedical Science, Taipei, Mar 21-22, 2009. 32. Lin YC, Huang SY, Duh CY, Jean YH, Chen WF, Wen ZH. Lemnalol, a natural marine
compound obtained from the Formosan soft coral Lemnalia cervicorni attenuates nociceptive responses and activity of the spinal glial cells in neuropathic rats. The 24th Joint Annual Conference of Biomedical Science, Taipei, Mar 21-22, 2009. 33. Huang SY, Chen CH, Chen NF, Lin YY, Sheu JH, Wen ZH. Sinularin, a marine nature
compound obtained from indigenous soft coral Sinularia querciformi, attenuates nociceptive responses and activity of the spinal glial cells in carrageenan injected rats. The 25th Joint Annual Conference of Biomedical Science, Taipei, Mar 27-28, 2010. 34. Sun YM, Lin YY, Su JH, Lee HP, Jean YH, Sheu JH, Wen ZH. Amelioration of
adjuvant-induced arthritis in rats by a marine-derived compound, Excavatolide B. The 25th Joint Annual Conference of Biomedical Science, Taipei, Mar 27-28, 2010. 35. Shen JW, Chen WF, Cho CL, Wen ZH. The effect of granulocyte-colony stimulating factor on
interferon--induced neuroinflammation in BV2 murine microglial cells. The 25th Joint Annual Conference of Biomedical Science, Taipei, Mar 27-28, 2010. 36. Shu LC, Wen ZH, Wu HC. Anti-inflammatory activities of 5,8,11-cis-eicosatrienoic acid. The
25th Joint Annual Conference of Biomedical Science, Taipei, Mar 27-28, 2010.

Source: http://www.mr.nsysu.edu.tw/teacher/xzhpapers.pdf