Chemwatch msds

ULTRACOLOR AEROSOL SURVEY MARKER -
NON FLUORO COLOUR RANGE
Material Safety Data Sheet
Issue Date: 25-Sept-2009
CHEMWATCH 63019
Version No:2.0
Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
PRODUCT NAME
SYNONYMS
PROPER SHIPPING NAME
PRODUCT USE
SUPPLIER
Company:Ultracolor Products Address: 3 Anderson Place South Windsor NSW, 2756 AUS Telephone: +61 2 4577 4866 Fax: +61 2 4577 6919 Section 2 - HAZARDS IDENTIFICATION
STATEMENT OF HAZARDOUS NATURE
HAZARDOUS SUBSTANCE. DANGEROUS GOODS. According to the Criteria of NOHSC, and the ADG
Code.
CHEMWATCH HAZARD RATINGS
SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4 POISONS SCHEDULE
» Keep away from sources of ignition. No smoking. » Do not breathe gas/ fumes/ vapour/ spray. » Limited evidence of a carcinogenic effect. » Keep container in a wel ventilated place. » Risk of explosion if heated under confinement. » Avoid exposure - obtain special instructions before use. » Harmful: danger of serious damage to health by » To clean the floor and al objects contaminated by this prolonged exposure through inhalation. » Possible risk of harm to the unborn child. » Vapours may cause drowsiness and dizziness. » Keep away from food drink and animal feeding stuffs. » Inhalation and/or skin contact may produce » In case of contact with eyes rinse with plenty of water and contact Doctor or Poisons Information Centre. » Cumulative effects may result fol owing » If swal owed IMMEDIATELY contact Doctor or Poisons Information Centre (show this container or label). » May produce discomfort of the respiratory » This material and its container must be disposed of as Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS
Section 4 - FIRST AID MEASURES
SWALLOWED
· For advice, contact a Poisons Information Centre or a doctor.
· If swal owed do NOT induce vomiting.
· If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain open airway and prevent aspiration.
· Observe the patient careful y.
· Never give liquid to a person showing signs of being sleepy or with reduced awareness; i.e. becoming unconscious· Give water to rinse out mouth, then provide liquid slowly and as much as casualty can comfortably drink.
· Seek medical advice. » If this product comes in contact with the eyes:· Immediately hold eyelids apart and flush the eye continuously with running water.
· Ensure complete irrigation of the eye by keeping eyelids apart and away from eye and moving the eyelids by occasional y lifting the upper and lower lids.
· Continue flushing until advised to stop by the Poisons Information Centre or a doctor, or for at least 15 minutes.
· Transport to hospital or doctor without delay.
· Removal of contact lenses after an eye injury should only be undertaken by skil ed personnel. » If solids or aerosol mists are deposited upon the skin:· Flush skin and hair with running water (and soap if available).
· Remove any adhering solids with industrial skin cleansing cream.
· DO NOT use solvents.
· Seek medical attention in the event of irritation. · If fumes or combustion products are inhaled remove from contaminated area.
· Lay patient down. Keep warm and rested.
· Prostheses such as false teeth, which may block airway, should be removed, where possible, prior to initiating first aid procedures.
· Apply artificial respiration if not breathing, preferably with a demand valve resuscitator, bag-valve mask device, or pocket mask as trained. Perform CPR if necessary.
· Transport to hospital, or doctor. NOTES TO PHYSICIAN
» Fol owing acute or short term repeated exposures to toluene:· Toluene is absorbed across the alveolar barrier, the blood/air mixture being 11.2/15.6 (at 37 degrees C.) The concentration of toluene, in expired breath, is of the order of 18 ppm fol owing sustained exposure to 100 ppm. The tissue/blood proportion is 1/3 except in adipose where the proportion is 8/10.
· Metabolism by microsomal mono-oxygenation, results in the production of hippuric acid. This may be detected in the urine in amounts between 0.5 and 2.5 g/24 hr which represents, on average 0.8 gm/gm of creatinine. The biological half-life of hippuric acid is in the order of 1-2 hours.
· Primary threat to life from ingestion and/or inhalation is respiratory failure.
· Patients should be quickly evaluated for signs of respiratory distress (eg cyanosis, tachypnoea, intercostal retraction, obtundation) and given oxygen. Patients with inadequate tidal volumes or poor arterial blood gases (pO2 <50 mm Hg or pCO2 > 50 mm Hg) should be intubated.
· Arrhythmias complicate some hydrocarbon ingestion and/or inhalation and electrocardiographic evidence of myocardial damage has been reported; intravenous lines and cardiac monitors should be established in obviously symptomatic patients. The lungs excrete inhaled solvents, so that hyperventilation improves clearance.
· A chest x-ray should be taken immediately after stabilisation of breathing and circulation to document aspiration and detect the presence of pneumothorax.
· Epinephrine (adrenaline) is not recommended for treatment of bronchospasm because of potential myocardial sensitisation to catecholamines. Inhaled cardioselective bronchodilators (e.g. Alupent, Salbutamol) are the preferred agents, with aminophyl ine a second choice.
· Lavage is indicated in patients who require decontamination; ensure use.
BIOLOGICAL EXPOSURE INDEX - BEI These represent the determinants observed in specimens col ected from a healthy worker exposed at the Exposure Standard (ES or TLV): NS: Non-specific determinant; also observed after exposure to other material B: Background levels occur in specimens col ected from subjects NOT exposed.
Section 5 - FIRE FIGHTING MEASURES
EXTINGUISHING MEDIA
· Water spray or fog.
· Foam.
· Dry chemical powder.
· BCF (where regulations permit).
· Carbon dioxide.
FIRE FIGHTING
· Alert Fire Brigade and tel them location and nature of hazard.
· May be violently or explosively reactive.
· Wear breathing apparatus plus protective gloves.
· Prevent, by any means available, spil age from entering drains or water course.
· If safe, switch off electrical equipment until vapour fire hazard removed.
· Use water delivered as a fine spray to control fire and cool adjacent area.
· DO NOT approach containers suspected to be hot.
· Cool fire exposed containers with water spray from a protected location.
· If safe to do so, remove containers from path of fire.
· Equipment should be thoroughly decontaminated after use.
FIRE/EXPLOSION HAZARD
· Liquid and vapour are highly flammable.
· Severe fire hazard when exposed to heat or flame.
· Vapour forms an explosive mixture with air.
· Severe explosion hazard, in the form of vapour, when exposed to flame or spark.
· Vapour may travel a considerable distance to source of ignition.
· Heating may cause expansion or decomposition with violent container rupture.
· Aerosol cans may explode on exposure to naked flames.
· Rupturing containers may rocket and scatter burning materials.
· Hazards may not be restricted to pressure effects.
· May emit acrid, poisonous or corrosive fumes.
· On combustion, may emit toxic fumes of carbon monoxide (CO).
Other combustion products include: carbon dioxide (CO2).
FIRE INCOMPATIBILITY
» Avoid contamination with strong oxidising agents as ignition may result.
HAZCHEM: None
Personal Protective Equipment
Section 6 - ACCIDENTAL RELEASE MEASURES
MINOR SPILLS
· Avoid breathing vapours and contact with skin and eyes.
· Wear protective clothing, impervious gloves and safety glasses.
· Shut off al possible sources of ignition and increase ventilation.
· Wipe up.
· If safe, damaged cans should be placed in a container outdoors, away from al ignition sources, until pressure has dissipated.
· Undamaged cans should be gathered and stowed safely.
MAJOR SPILLS
· Clear area of personnel and move upwind.
· Alert Fire Brigade and tel them location and nature of hazard.
· May be violently or explosively reactive.
· Wear breathing apparatus plus protective gloves.
· Prevent, by any means available, spil age from entering drains or water courses· No smoking, naked lights or ignition sources.
· Increase ventilation.
· Stop leak if safe to do so.
· Water spray or fog may be used to disperse / absorb vapour.
· Absorb or cover spil with sand, earth, inert materials or vermiculite.
· If safe, damaged cans should be placed in a container outdoors, away from ignition sources, until pressure has dissipated.
· Undamaged cans should be gathered and stowed safely.
· Col ect residues and seal in label ed drums for disposal.
PROTECTIVE ACTIONS FOR SPILL
From IERG (Canada/Australia)Isolation Distance -Downwind Protection Distance 8 metresIERG Number 49 FOOTNOTES1 PROTECTIVE ACTION ZONE is defined as the area in which people are at risk of harmful exposure. This zone assumes that random changes in wind direction confines the vapour plume to an area within 30 degrees on either side of the predominant wind direction, resulting in a crosswind protective action distance equal to the downwind protective action distance.
2 PROTECTIVE ACTIONS should be initiated to the extent possible, beginning with those closest to the spil and working away from the site in the downwind direction. Within the protective action zone a level of vapour concentration may exist resulting in nearly al unprotected persons becoming incapacitated and unable to take protective action and/or incurring serious or irreversible health effects.
3 INITIAL ISOLATION ZONE is determined as an area, including upwind of the incident, within which a high probability of localised wind reversal may expose nearly al persons without appropriate protection to life-threatening concentrations of the material.
4 SMALL SPILLS involve a leaking package of 200 litres (55 US gal ons) or less, such as a drum (jerrican or box with inner containers). Larger packages leaking less than 200 litres and compressed gas leaking from a smal cylinder are also considered "smal spil s".
LARGE SPILLS involve many smal leaking packages or a leaking package of greater than 200 litres, such as a cargo tank, portable tank or a "one-tonne" compressed gas cylinder.
5 Guide 126 is taken from the US DOT emergency response guide book.
6 IERG information is derived from CANUTEC - Transport Canada.
EMERGENCY RESPONSE PLANNING GUIDELINES (ERPG)
The maximum airborne concentration below which it is believed that nearly al individuals could be exposed for up to one hour WITHOUT experiencing or developing life-threatening health effects is: toluene 1000ppm irreversible or other serious effects or symptoms which could impair an individual's ability to take protective action other than mild, transient adverse effects without perceiving a clearly defined odour is: toluene 50ppm American Industrial Hygiene Association (AIHA) Ingredients considered according to the fol owing cutoffs Very Toxic (T+) >= 0.1% Toxic (T) >= 3.0% R50 >= 0.25% Corrosive (C) >= 5.0% R51 >= 2.5%else >= 10%where percentage is percentage of ingredient found in the mixture Personal Protective Equipment advice is contained in Section 8 of the MSDS.
Section 7 - HANDLING AND STORAGE
PROCEDURE FOR HANDLING
· Avoid al personal contact, including inhalation.
· Wear protective clothing when risk of exposure occurs.
· Use in a wel -ventilated area.
· Prevent concentration in hol ows and sumps.
· DO NOT enter confined spaces until atmosphere has been checked.
· Avoid smoking, naked lights or ignition sources.
· Avoid contact with incompatible materials.
· When handling, DO NOT eat, drink or smoke.
· DO NOT incinerate or puncture aerosol cans.
· DO NOT spray directly on humans, exposed food or food utensils.
· Avoid physical damage to containers.
· Always wash hands with soap and water after handling.
· Work clothes should be laundered separately.
· Use good occupational work practice.
· Observe manufacturer's storing and handling recommendations.
· Atmosphere should be regularly checked against established exposure standards to ensure safe working conditions are maintained. SUITABLE CONTAINER
· Aerosol dispenser.
· Check that containers are clearly label ed. STORAGE INCOMPATIBILITY
STORAGE REQUIREMENTS
· Store in original containers in approved flame-proof area.
· DO NOT store in pits, depressions, basements or areas where vapours may be trapped.
· No smoking, naked lights, heat or ignition sources.
· Keep containers securely sealed. Contents under pressure.
· Store away from incompatible materials.
· Store in a cool, dry, wel ventilated area in an upright position.
· Avoid storage at temperatures higher than 40 deg C.
· Protect containers against physical damage and check regularly for leaks.
· Observe manufacturer's storing and handling recommendations. _____________________________________________________
SAFE STORAGE WITH OTHER CLASSIFIED CHEMICALS
_____________________________________________________
O: May be stored together with specific preventions Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
EXPOSURE CONTROLS
StandardsAustralia Exposure titanium dioxide propel ant (LPG (liquified petroleum gas)) EMERGENCY EXPOSURE LIMITS
NOTESValues marked LEL indicate that the IDLH was based on 10% of the lower explosive limit for safety considerations even though the relevant toxicological data indicated that irreversible health effects or impairment of escape existed only at higher concentrations.
ODOUR SAFETY FACTOR (OSF)
OSF=0.16 (hydrocarbon propel ant)» Exposed individuals are NOT reasonably expected to be warned, by smel , that the Exposure Standard is being exceeded.
Odour Safety Factor (OSF) is determined to fal into either Class C, D or E.
The Odour Safety Factor (OSF) is defined as: OSF= Exposure Standard (TWA) ppm/ Odour Threshold Value (OTV) ppm Over 90% of exposed individuals are aware by smel that the Exposure Standard (TLV-TWA for example) is being reached, even when distracted by working activities As "A" for 50-90% of persons being As "A" for less than 50% of persons tested perceive by smel that the Exposure Standard is being reached As "D" for less than 10% of persons MATERIAL DATA
» None assigned. Refer to individual constituents.
WARNING:Intentional misuse by concentrating/inhaling contents may be lethal.
INGREDIENT DATA
CALCIUM CARBONATE:TITANIUM DIOXIDE: » Sensory irritants are chemicals that produce temporary and undesirable side-effects on the eyes, nose or throat. Historical y occupational exposure standards for these irritants have been based on observation of workers' responses to various airborne concentrations. Present day expectations require that nearly every individual should be protected against even minor sensory irritation and exposure standards are established using uncertainty factors or safety factors of 5 to 10 or more. On occasion animal no-observable-effect-levels (NOEL) are used to determine these limits where human results are unavailable. An additional approach, typical y used by the TLV committee (USA) in determining respiratory standards for this group of chemicals, has been to assign ceiling values (TLV C) to rapidly acting irritants and to assign short-term exposure limits (TLV STELs) when the weight of evidence from irritation, bioaccumulation and other endpoints combine to warrant such a limit. In contrast the MAK Commission (Germany) uses a five-category system based on intensive odour, local irritation, and elimination half-life. However this system is being replaced to be consistent with the European Union (EU) Scientific Committee for Occupational Exposure Limits (SCOEL); this is more closely al ied to that of the USA.
OSHA (USA) concluded that exposure to sensory irritants can: · cause inflammation · cause increased susceptibility to other irritants and infectious agents · lead to permanent injury or dysfunction · permit greater absorption of hazardous substances and · acclimate the worker to the irritant warning properties of these substances thus increasing the risk of overexposure.
TOLUENE: » For toluene: Odour Threshold Value: 0.16-6.7 (detection), 1.9-69 (recognition) NOTE: Detector tubes measuring in excess of 5 ppm, are available.
High concentrations of toluene in the air produce depression of the central nervous system (CNS) in humans. Intentional toluene exposure (glue-sniffing) at maternal y-intoxicating concentration has also produced birth defects. Foetotoxicity appears at levels associated with CNS narcosis and probably occurs only in those with chronic toluene-induced kidney failure. Exposure at or below the recommended TLV-TWA is thought to prevent transient headache and irritation, to provide a measure of safety for possible disturbances to human reproduction, the prevention of reductions in cognitive responses reported amongst humans inhaling greater than 40 ppm, and the significant risks of hepatotoxic, behavioural and nervous system effects (including impaired reaction time and incoordination). Although toluene/ethanol interactions are wel recognised, the degree of protection afforded by the TLV-TWA among drinkers is not known.
Odour Safety Factor(OSF) OSF=17 (TOLUENE).
TITANIUM DIOXIDE: » It is the goal of the ACGIH (and other Agencies) to recommend TLVs (or their equivalent) for al substances for which there is evidence of health effects at airborne concentrations encountered in the workplace.
At this time no TLV has been established, even though this material may produce adverse health effects (as evidenced in animal experiments or clinical experience). Airborne concentrations must be maintained as low as is practical y possible and occupational exposure must be kept to a minimum.
NOTE: The ACGIH occupational exposure standard for Particles Not Otherwise Specified (P.N.O.S) does NOT apply.
Animal exposed by inhalation to 10 mg/m3 titanium dioxide show no significant fibrosis, possibly reversible tissue reaction. The architecture of lung air spaces remains intact.
WARNING: This substance has been classified by the IARC as Group 2B: Possibly Carcinogenic to Humans.
CALCIUM CARBONATE: The TLV-TWA is thought to be protective against the significant risk of physical irritation associated with exposure.
HYDROCARBON PROPELLANT: » Not available. Refer to individual constituents.
PERSONAL PROTECTION
» No special equipment for minor exposure i.e. when handling smal quantities.
· OTHERWISE:· Safety glasses with side shields.
· Contact lenses may pose a special hazard; soft contact lenses may absorb and concentrate irritants. A written policy document, describing the wearing of lens or restrictions on use, should be created for each workplace or task. This should include a review of lens absorption and adsorption for the class of chemicals in use and an account of injury experience. Medical and first-aid personnel should be trained in their removal and suitable equipment should be readily available. In the event of chemical exposure, begin eye irrigation immediately and remove contact lens as soon as practicable. Lens should be removed at the first signs of eye redness or irritation - lens should be removed in a clean environment only after workers have washed hands thoroughly. [CDC NIOSH Current Intel igence Bul etin 59].
HANDS/FEET
· No special equipment needed when handling smal quantities.
· OTHERWISE: Wear general protective gloves, eg. light weight rubber gloves. Or as required: Wear chemical protective gloves, eg. PVC. Wear safety footwear.
» No special equipment needed when handling smal quantities.
OTHERWISE:· Overal s.
· Skin cleansing cream.
· Eyewash unit.
RESPIRATOR
» Selection of the Class and Type of respirator will depend upon the level of breathing zone contaminant and the chemical nature of the contaminant. Protection Factors (defined as the ratio of contaminant outside and inside the mask) may also be important.
Breathing Zone Level ppm Maximum Protection Factor Half-face Respirator * - Continuous Flow ** - Continuous-flow or positive pressure demand.
ENGINEERING CONTROLS
» General exhaust is adequate under normal operating conditions. If risk of overexposure exists, wear SAA approved respirator. Correct fit is essential to obtain adequate protection. Provide adequate ventilation in warehouse or closed storage areas. Air contaminants generated in the workplace possess varying "escape" velocities which, in turn, determine the "capture velocities" of fresh circulating air required to effectively remove the contaminant.
solvent, vapours, degreasing etc., evaporating from tank 0.25-0.5 m/s (50-100 f/min) aerosols, fumes from pouring operations, intermittent container fil ing, low speed conveyer transfers, welding, 0.5-1 m/s (100-200 f/min.) spray drift, plating acid fumes, pickling (released at low velocity into zone of active generation) direct spray, spray painting in shal ow booths, drum fil ing, conveyer loading, crusher dusts, gas discharge (active generation into zone of rapid air motion) grinding, abrasive blasting, tumbling, high speed wheel generated dusts (released at high initial velocity into zone of very high rapid air motion).
Within each range the appropriate value depends on: 1: Room air currents minimal or favourable to capture 2: Contaminants of low toxicity or of nuisance value only 2: Contaminants of high toxicity 4: Large hood or large air mass in motion Simple theory shows that air velocity fal s rapidly with distance away from the opening of a simple extraction pipe. Velocity general y decreases with the square of distance from the extraction point (in simple cases). Therefore the air speed at the extraction point should be adjusted, accordingly, after reference to distance from the contaminating source. The air velocity at the extraction fan, for example, should be a minimum of 1-2 m/s (200-400 f/min.) for extraction of solvents generated in a tank 2 meters distant from the extraction point. Other mechanical considerations, producing performance deficits within the extraction apparatus, make it essential that theoretical air velocities are multiplied by factors of 10 or more when extraction systems are instal ed or used.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
APPEARANCE
Various coloured liquid with aromatic solvent odour; does not mix with water. Suppliedin aerosol pack containing hydrocarbon propel ant.
PHYSICAL PROPERTIES
Liquid.
Gas.
Does not mix with water. Specific Gravity (water=1): Not available. Volatile Component (%vol): Not available Relative Vapour Density (air=1): Not available. Lower Explosive Limit (%): Not available. Upper Explosive Limit (%): Not available. Section 10 - CHEMICAL STABILITY AND REACTIVITY INFORMATION
CONDITIONS CONTRIBUTING TO INSTABILITY
· Elevated temperatures.
· Presence of open flame.
· Product is considered stable.
· Hazardous polymerisation wil not occur. For incompatible materials - refer to Section 7 - Handling and Storage. Section 11 - TOXICOLOGICAL INFORMATION
POTENTIAL HEALTH EFFECTS
ACUTE HEALTH EFFECTS
SWALLOWED
» The liquid is discomforting to the gastro-intestinal tract and may be harmful if swal owed.
Ingestion may result in nausea, pain, vomiting. Vomit entering the lungs by aspiration may cause potential y lethal chemical pneumonitis.
Considered an unlikely route of entry in commercial/industrial environments.
» The liquid is highly discomforting and is capable of causing pain and severe conjunctivitis. Corneal injury may develop, with possible permanent impairment of vision, if not promptly and adequately treated.
The vapour is discomforting to the eyes.
The material may produce severe irritation to the eye causing pronounced inflammation. Repeated or prolonged exposure to irritants may produce conjunctivitis.
» The liquid is discomforting to the skin and is capable of causing skin reactions which may lead to dermatitis from repeated exposures over long periods.
Toxic effects may result from skin absorption.
The material may cause skin irritation after prolonged or repeated exposure and may produce on contact skin redness, swel ing, the production of vesicles, scaling and thickening of the skin.
» The vapour/mist is discomforting to the upper respiratory tract.
Inhalation hazard is increased at higher temperatures.
Inhalation of high concentrations of gas/vapour causes lung irritation with coughing and nausea, central nervous depression with headache and dizziness, slowing of reflexes, fatigue and inco-ordination.
If exposure to highly concentrated solvent atmosphere is prolonged this may lead to narcosis, unconsciousness, even coma and possible death.
WARNING:Intentional misuse by concentrating/inhaling contents may be lethal.
CHRONIC HEALTH EFFECTS
» Chronic solvent inhalation exposures may result in nervous system impairment and liver and blood changes. [PATTYS].
Prolonged or continuous skin contact with the liquid may cause defatting with drying, cracking, irritation and dermatitis fol owing.
WARNING: Aerosol containers may present pressure related hazards.
TOXICITY AND IRRITATION
» Not available. Refer to individual constituents.
TOLUENE:» unless otherwise specified data extracted from RTECS - Register of Toxic Effects of Chemical Substances.
Dermal (rabbit) LD50: 12124 mg/kg » The material may cause skin irritation after prolonged or repeated exposure and may produce on contact skin redness, swel ing, the production of vesicles, scaling and thickening of the skin.
For toluene:Acute ToxicityHumans exposed to intermediate to high levels of toluene for short periods of time experience adverse central nervous system effects ranging from headaches to intoxication, convulsions, narcosis, and death. Similar effects are observed in short-term animal studies.
Humans - Toluene ingestion or inhalation can result in severe central nervous system depression, and in large doses, can act as a narcotic. The ingestion of about 60 mL resulted in fatal nervous system depression within 30 minutes in one reported case.
Constriction and necrosis of myocardial fibers, markedly swol en liver, congestion and haemorrhage of the lungs and acute tubular necrosis were found on autopsy.
Central nervous system effects (headaches, dizziness, intoxication) and eye irritation occurred fol owing inhalation exposure to 100 ppm toluene 6 hours/day for 4 days.
Exposure to 600 ppm for 8 hours resulted in the same and more serious symptoms including euphoria, dilated pupils, convulsions, and nausea . Exposure to 10,000-30,000 ppm has been reported to cause narcosis and deathToluene can also strip the skin of lipids causing dermatitisAnimals - The initial effects are instability and incoordination, lachrymation and sniffles (respiratory exposure), fol owed by narcosis. Animals die of respiratory failure from severe nervous system depression. Cloudy swel ing of the kidneys was reported in rats fol owing inhalation exposure to 1600 ppm, 18-20 hours/day for 3 daysSubchronic/Chronic Effects:Repeat doses of toluene cause adverse central nervous system effects and can damage the upper respiratory system, the liver, and the kidney. Adverse effects occur as a result from both oral and the inhalation exposures. A reported lowest-observed-effect level in humans for adverse neurobehavioral effects is 88 ppm.
Humans - Chronic occupational exposure and incidences of toluene abuse have resulted in hepatomegaly and liver function changes. It has also resulted in nephrotoxicity and, in one case, was a cardiac sensitiser and fatal cardiotoxin.
Neural and cerebel ar dystrophy were reported in several cases of habitual "glue sniffing." An epidemiological study in France on workers chronical y exposed to toluene fumes reported leukopenia and neutropenia. Exposure levels were not given in the secondary reference; however, the average urinary excretion of hippuric acid, a metabolite of toluene, was given as 4 g/L compared to a normal level of 0.6 g/LAnimals - The major target organs for the subchronic/chronic toxicity of toluene are the nervous system, liver, and kidney. Depressed immune response has been reported in male mice given doses of 105 mg/kg/day for 28 days. Toluene in corn oil administered to F344 male and female rats by gavage 5 days/week for 13 weeks, induced prostration, hypoactivity, ataxia, piloerection, lachrymation, excess salivation, and body tremors at doses 2500 mg/kg. Liver, kidney, and heart weights were also increased at this dose and histopathologic lesions were seen in the liver, kidneys, brain and urinary bladder. The no-observed-adverse effect level (NOAEL) for the study was 312 mg/kg (223 mg/kg/day) and the lowest-observed-adverse effect level (LOAEL) for the study was 625 mg/kg (446 mg/kg/day) .
Developmental/Reproductive ToxicityExposures to high levels of toluene can result in adverse effects in the developing human foetus. Several studies have indicated that high levels of toluene can also adversely effect the developing offspring in laboratory animals.
Humans - Variable growth, microcephaly, CNS dysfunction, attentional deficits, minor craniofacial and limb abnormalities, and developmental delay were seen in three children exposed to toluene in utero as a result of maternal solvent abuse before and during pregnancyAnimals - Sternebral alterations, extra ribs, and missing tails were reported fol owing treatment of rats with 1500 mg/m3 toluene 24 hours/day during days 9-14 of gestation. Two of the dams died during the exposure. Another group of rats received 1000 mg/m3 8 hours/day during days 1-21 of gestation. No maternal deaths or toxicity occurred, however, minor skeletal retardation was present in the exposed fetuses. CFLP Mice were exposed to 500 or 1500 mg/m3 toluene continuously during days 6-13 of pregnancy. Al dams died at the high dose during the first 24 hours of exposure, however none died at 500 mg/m3. Decreased foetal weight was reported, but there were no differences in the incidences of skeletal malformations or anomalies between the treated and control offspring.
Absorption - Studies in humans and animals have demonstrated that toluene is readily absorbed via the lungs and the gastrointestinal tract. Absorption through the skin is estimated at about 1% of that absorbed by the lungs when exposed to toluene vapor.
Dermal absorption is expected to be higher upon exposure to the liquid; however, exposure is limited by the rapid evaporation of toluene .
Distribution - In studies with mice exposed to radiolabeled toluene by inhalation, high levels of radioactivity were present in body fat, bone marrow, spinal nerves, spinal cord, and brain white matter. Lower levels of radioactivity were present in blood, kidney, and liver. Accumulation of toluene has general y been found in adipose tissue, other tissues with high fat content, and in highly vascularised tissues .
Metabolism - The metabolites of inhaled or ingested toluene include benzyl alcohol resulting from the hydroxylation of the methyl group. Further oxidation results in the formation of benzaldehyde and benzoic acid. The latter is conjugated with glycine to yield hippuric acid or reacted with glucuronic acid to form benzoyl glucuronide. o-cresol and p-cresol formed by ring hydroxylation are considered minor metabolitesExcretion - Toluene is primarily (60-70%) excreted through the urine as hippuric acid. The excretion of benzoyl glucuronide accounts for 10-20%, and excretion of unchanged toluene through the lungs also accounts for 10-20%. Excretion of hippuric acid is usual y complete within 24 hours after exposure.
TITANIUM DIOXIDE:» unless otherwise specified data extracted from RTECS - Register of Toxic Effects of Chemical Substances.
Oral (Mouse) LD50: >10000 mg/kg * » The material may produce moderate eye irritation leading to inflammation. Repeated or prolonged exposure to irritants may produce conjunctivitis.
The material may cause skin irritation after prolonged or repeated exposure and may produce on contact skin redness, swel ing, the production of vesicles, scaling and thickening of the skin.
For titanium dioxide:Humans can be exposed to titanium dioxide via inhalation, ingestion or dermal contact. In human lungs, the clearance kinetics of titanium dioxide is poorly characterized relative to that in experimental animals. (General particle characteristics and host factors that are considered to affect deposition and retention patterns of inhaled, poorly soluble particles such as titanium dioxide are summarized in the monograph on carbon black.) With regard to inhaled titanium dioxide, human data are mainly available from case reports that showed deposits of titanium dioxide in lung tissue as wel as in lymph nodes. A single clinical study of oral ingestion of fine titanium dioxide showed particle size-dependent absorption by the gastrointestinal tract and large interindividual variations in blood levels of titanium dioxide. Studies on the application of sunscreens containing ultrafine titanium dioxide to healthy skin of human volunteers revealed that titanium dioxide particles only penetrate into the outermost layers of the stratum corneum, suggesting that healthy skin is an effective barrier to titanium dioxide. There are no studies on penetration of titanium dioxide in compromised skin.
Respiratory effects that have been observed among groups of titanium dioxide-exposed workers include decline in lung function, pleural disease with plaques and pleural thickening, and mild fibrotic changes. However, the workers in these studies were also exposed to asbestos and/or silica.
No data were available on genotoxic effects in titanium dioxide-exposed humans.
Many data on deposition, retention and clearance of titanium dioxide in experimental animals are available for the inhalation route. Titanium dioxide inhalation studies showed differences — both for normalized pulmonary burden (deposited mass per dry lung, mass per body weight) and clearance kinetics — among rodent species including rats of different size, age and strain. Clearance of titanium dioxide is also affected by pre-exposure to gaseous pol utants or co-exposure to cytotoxic aerosols. Differences in dose rate or clearance kinetics and the appearance of focal areas of high particle burden have been implicated in the higher toxic and inflammatory lung responses to intratracheal y instil ed vs inhaled titanium dioxide particles. Experimental studies with titanium dioxide have demonstrated that rodents experience dose-dependent impairment of alveolar macrophage-mediated clearance. Hamsters have the most efficient clearance of inhaled titanium dioxide. Ultrafine primary particles of titanium dioxide are more slowly cleared than their fine counterparts.
Titanium dioxide causes varying degrees of inflammation and associated pulmonary effects including lung epithelial cel injury, cholesterol granulomas and fibrosis. Rodents experience stronger pulmonary effects after exposure to ultrafine titanium dioxide particles compared with fine particles on a mass basis. These differences are related to lung burden in terms of particle surface area, and are considered to result from impaired phagocytosis and sequestration of ultrafine particles into the interstitium.
Fine titanium dioxide particles show minimal cytotoxicity to and inflammatory/pro-fibrotic mediator release from primary human alveolar macrophages in vitro compared with other particles. Ultrafine titanium dioxide particles inhibit phagocytosis of alveolar macrophages in vitro at mass dose concentrations at which this effect does not occur with fine titanium dioxide. In-vitro studies with fine and ultrafine titanium dioxide and purified DNA show induction of DNA damage that is suggestive of the generation of reactive oxygen species by both particle types. This effect is stronger for ultrafine than for fine titanium oxide, and is markedly enhanced by exposure to simulated sunlight/ultraviolet light.
Animal carcinogenicity dataPigmentary and ultrafine titanium dioxide were tested for carcinogenicity by oral administration in mice and rats, by inhalation in rats and female mice, by intratracheal administration in hamsters and female rats and mice, by subcutaneous injection in rats and by intraperitoneal administration in male mice and female rats.
In one inhalation study, the incidence of benign and malignant lung tumours was increased in female rats. In another inhalation study, the incidences of lung adenomas were increased in the high-dose groups of male and female rats. Cystic keratinizing lesions that were diagnosed as squamous-cel carcinomas but re-evaluated as non-neoplastic pulmonary keratinizing cysts were also observed in the high-dose groups of female rats. Two inhalation studies in rats and one in female mice were negative.
Intratracheal y instil ed female rats showed an increased incidence of both benign and malignant lung tumours fol owing treatment with two types of titanium dioxide. Tumour incidence was not increased in intratracheal y instil ed hamsters and female mice.
In-vivo studies have shown enhanced micronucleus formation in bone marrow and peripheral blood lymphocytes of intraperitoneal y instil ed mice. Increased Hprt mutations were seen in lung epithelial cel s isolated from titanium dioxide-instil ed rats. In another study, no enhanced oxidative DNA damage was observed in lung tissues of rats that were intratracheal y instil ed with titanium dioxide. The results of most in-vitro genotoxicity studies with titanium dioxide were negative.
* IUCLID CALCIUM CARBONATE:» unless otherwise specified data extracted from RTECS - Register of Toxic Effects of Chemical Substances.
Skin (rabbit): 500 mg/24h-Moderate Eye (rabbit): 0.75 mg/24h - SEVERE » The material may produce severe irritation to the eye causing pronounced inflammation. Repeated or prolonged exposure to irritants may produce conjunctivitis.
The material may cause skin irritation after prolonged or repeated exposure and may produce on contact skin redness, swel ing, the production of vesicles, scaling and thickening of the skin.
No evidence of carcinogenic properties. No evidence of mutagenic orteratogenic effects.
HYDROCARBON PROPELLANT:» None assigned. Refer to individual constituents.
CARCINOGEN
International Agency for Research on Cancer (IARC) CarcinogensInternational Agency for Research on Cancer REPROTOXIN
ILO Chemicals in the electronics industry that Section 12 - ECOLOGICAL INFORMATION
Refer to data for ingredients, which fol ows: TOLUENE:» Hazardous Air Pol utant: Yes» Fish LC50 (96hr.) (mg/l): 7.3- 22.8» BCF<100: 13.2 (EELS» log Kow (Sangster 1997): 2.73» log Pow (Verschueren 1983): 2.69» BOD5: 5%» COD: 21%» ThOD: 3.13» Half- life Soil - High (hours): 528» Half- life Soil - Low (hours): 96» Half- life Air - High (hours): 104» Half- life Air - Low (hours): 10» Half- life Surface water - High (hours): 528» Half- life Surface water - Low (hours): 96» Half- life Ground water - High (hours): 672» Half- life Ground water - Low (hours): 168» Aqueous biodegradation - Aerobic - High (hours): 528» Aqueous biodegradation - Aerobic - Low (hours): 96» Aqueous biodegradation - Anaerobic - High (hours): 5040» Aqueous biodegradation - Anaerobic - Low (hours): 1344» Aqueous biodegradation - Removal secondary treatment - High (hours): 75%» Photolysis maximum light absorption - High (nano- m): 268» Photolysis maximum light absorption - Low (nano- m): 253.5» Photooxidation half- life water - High (hours): 1284» Photooxidation half- life water - Low (hours): 321» Photooxidation half- life air - High (hours): 104» Photooxidation half- life air - Low (hours): 10 log Kow : 2.1-3log Koc : 1.12-2.85Koc : 37-260log Kom : 1.39-2.89Half-life (hr) air : 2.4-104Half-life (hr) H2O surface water : 5.55-528Half-life (hr) H2O ground : 168-2628Half-life (hr) soil : <48-240Henry's Pa m3 /mol: 518-694Henry's atm m3 /mol: 5.94E-03BOD 5 0.86-2.12, 5%COD : 0.7-2.52,21-27%ThOD : 3.13BCF : 1.67-380log BCF : 0.22-3.28Environmental fate:Transport: The majority of toluene evaporates to the atmosphere from the water and soil.It is moderately retarded by adsorption to soils rich in organic material (Koc = 259), therefore, transport to ground water is dependent on the soil composition. In unsaturated topsoil containing organic material, it has been estimated that 97% of the toluene is adsorbed to the soil and only about 2% is in the soil-water phase and transported with flowing groundwater. There is little retardation in sandy soils and 2-13% of the toluene was estimated to migrate with flowing water; the remainder was volatilised, biodegraded, or unaccounted for. In saturated deep soils with no soil-air phase, about 48% may be transported with flowing groundwater.
Transformation/Persistence:Air - The main degradation pathway for toluene in the atmosphere is reaction with photochemical y produced hydroxyl radicals. The estimated atmospheric half life for toluene is about 13 hours. Toluene is also oxidised by reactions with atmospheric nitrogen dioxide, oxygen, and ozone, but these are minor degradation pathways. Photolysis is not considered a significant degradative pathway for tolueneSoil - In surface soil, volatilisation to air is an important fate process for toluene. Biodegradation of toluene has been demonstrated in the laboratory to occur with a half life of about 1 hour. In the environment, biodegradation of toluene to carbon dioxide occurs with a typical half life of 1-7 days.
Water - An important fate process for toluene is volatilization, the rate of which depends on the amount of turbulence in the surface water .The volatilisation of toluene from static water has a half life of 1-16 days, whereas from turbulent water the half life is 5-6 hours. Degradation of toluene in surface water occurs primarily by biodegradation with a half life of less than one day under favorable conditions (presence of microorganisms, microbial adaptation, and optimum temperature). Biodegradation also occurs in shal ow groundwater and in salt water at a reduced rate). No data are available on anaerobic degradation of toluene in deep ground water conditions where aerobic degradation would be minimal .
Biota - Bioaccumulation in most organisms is limited by the metabolism of toluene into more polar compounds that have greater water solubility and a lower affinity for lipids. Bioaccumulation in the food chain is predicted to be low.
Ecotoxicity:Toluene has moderate acute toxicity to aquatic organisms; several toxicity values are in the range of greater than 1 mg/L and 100 mg/L.
Fish LC50 (96 h): fathead minnow (Pimephales promelas) 12.6-72 mg/l; Lepomis macrochirus 13-24 mg/l;guppy (Poecilia reticulata) 28.2-59.3 mg/l; channel catfish (Ictalurus punctatus) 240 mg/l; goldfish (Carassius auratus): 22.8-57.68 mg/lCrustaceans LC50 (96 h): grass shrimp (Palaemonetes pugio) 9.5 ppm, crab larvae stage (Cancer magister) 28 ppm; shrimp (Crangon franciscorum) 4.3 ppm; daggerblade grass shrimp (Palaemonetes pugio) 9.5 mg/lAlgae EC50 (24 h): green algae (Chlorel a vulgaris) 245 mg/l (growth); (72 h) green algae (Selenastrum capricornutum) 12.5 mg/l (growth).
TITANIUM DIOXIDE:» Metal-containing inorganic substances general y have negligible vapour pressure and are not expected to partition to air. Once released to surface waters and moist soils their fate depends on solubility and dissociation in water. Environmental processes (such as oxidation and the presence of acids or bases) may transform insoluble metals to more soluble ionic forms. Microbiological processes may also transform insoluble metals to more soluble forms. Such ionic species may bind to dissolved ligands or sorb to solid particles in aquatic or aqueous media. A significant proportion of dissolved/ sorbed metals will end up in sediments through the settling of suspended particles. The remaining metal ions can then be taken up by aquatic organisms.
When released to dry soil most metals will exhibit limited mobility and remain in the upper layer; some wil leach local y into ground water and/ or surface water ecosystems when soaked by rain or melt ice. Environmental processes may also be important in changing solubilities.
Even though many metals show few toxic effects at physiological pHs, transformation may introduce new or magnified effects.
A metal ion is considered infinitely persistent because it cannot degrade further.
The current state of science does not al ow for an unambiguous interpretation of various measures of bioaccumulation.
The counter-ion may also create heath and environmental concerns once isolated from the metal. Under normal physiological conditions the counter-ion may be essential y insoluble and may not be bioavailable.
Environmental processes may enhance bioavailability.
HYDROCARBON PROPELLANT:Marine Pol utant: Not Determined » For hydrocarbons:Environmental fate:The lower molecular weight hydrocarbons are expected to form a "slick" on the surface of waters after release in calm sea conditions. This is expected to evaporate and enter the atmosphere where it will be degraded through reaction with hydroxy radicals.
Some hydrocarbon will become associated with benthic sediments, and it is likely to be spread over a fairly wide area of sea floor. Marine sediments may be either aerobic or anaerobic. The material, in probability, is biodegradable, under aerobic conditions (isomerised olefins and alkenes show variable results). Evidence also suggests that the hydrocarbons may be degradable under anaerobic conditions although such degradation in benthic sediments may be a relatively slow process.
Under aerobic conditions hydrocarbons degrade to water and carbon dioxide, while under anaerobic processes they produce water, methane and carbon dioxide.
Alkenes have low log octanol/water partition coefficients (Kow) of about 1 and estimated bioconcentration factors (BCF) of about 10; aromatics have intermediate values (log Kow values of 2-3 and BCF values of 20-200), while C5 and greater alkanes have fairly high values (log Kow values of about 3-4.5 and BCF values of 100-1,500The estimated volatilisation half-lives for alkanes and benzene, toluene, ethylbenzene, xylene (BTEX) components were predicted as 7 days in ponds, 1.5 days in rivers, and 6 days in lakes. The volatilisation rate of naphthalene and its substituted derivatives were estimated to be slowerIndigenous microbes found in many natural settings (e.g., soils, groundwater, ponds) have been shown to be capable of degrading organic compounds. Unlike other fate processes that disperse contaminants in the environment, biodegradation can eliminate the contaminants without transferring them across media.
The final products of microbial degradation are carbon dioxide, water, and microbial biomass. The rate of hydrocarbon degradation depends on the chemical composition of the product released to the environment as wel as site-specific environmental factors. General y the straight chain hydrocarbons and the aromatics are degraded more readily than the highly branched aliphatic compounds. The n-alkanes, n-alkyl aromatics, and the aromatics in the C10-C22 range are the most readily biodegradable; n-alkanes, n-alkyl aromatics, and aromatics in the C5-C9 range are biodegradable at low concentrations by some microorganisms, but are general y preferential y removed by volatilisation and thus are unavailable in most environments; n-alkanes in the C1-C4 ranges are biodegradable only by a narrow range of specialised hydrocarbon degraders; and n-alkanes, n-alkyl aromatics, and aromatics above C22 are general y not available to degrading microorganisms. Hydrocarbons with condensed ring structures, such as PAHs with four or more rings, have been shown to be relatively resistant to biodegradation. PAHs with only 2 or 3 rings (e.g., naphthalene, anthracene) are more easily biodegraded. In almost al cases, the presence of oxygen is essential for effective biodegradation of oil. The ideal pH range to promote biodegradation is close to neutral (6-8). For most species, the optimal pH is slightly alkaline, that is, greater than 7.
Al biological transformations are affected by temperature. General y, as the temperature increases, biological activity tends to increase up to a temperature where enzyme denaturation occurs.
Atmospheric fate: Alkanes, isoalkanes, and cycloalkanes have half-lives on the order of 1-10 days, whereas alkenes, cycloalkenes, and substituted benzenes have half-lives of 1 day or less. Photochemical oxidation products include aldehydes, hydroxy compounds, nitro compounds, and peroxyacyl nitrates. Alkenes, certain substituted aromatics, and naphthalene are potential y susceptible to direct photolysis.
Ecotoxicity:Based on test results, as wel as theoretical considerations, the potential for bioaccumulation may be high. Toxic effects are often observed in species such as blue mussel, daphnia, freshwater green algae, marine copepods and amphipods.
The values of log Kow for individual hydrocarbons increase with increasing carbon number within homologous series of generic types. Quantitative structure activity relationships (QSAR), relating log Kow values of single hydrocarbons to toxicity, show that water solubility decreases more rapidly with increasing Kow than does the concentration causing effects. This relationship varies somewhat with species of hydrocarbon, but it fol ows that there is a log Kow limit for hydrocarbons, above which, they wil not exhibit acute toxicity; this limit is at a log Kow value of about 4 to 5. It has been confirmed experimental y that for fish and invertebrates, paraffinic hydrocarbons with a carbon number of 10 or higher (log Kow >5) show no acute toxicity and that alkylbenzenes with a carbon number of 14 or greater (log Kow >5) similarly show no acute toxicity. QSAR equations for chronic toxicity also suggest that there should be a point where hydrocarbons with high log Kow values become so insoluble in water that they wil not cause chronic toxicity, that is, that there is also a solubility cut-off for chronic toxicity. Thus, paraffinic hydrocarbons with carbon numbers of greater than 14 (log Kow >7.3) should show no measurable chronic toxicity.
» Drinking Water Standards: hydrocarbon total: 10 ug/l (UK max.).
Ecotoxicity
Section 13 - DISPOSAL CONSIDERATIONS
· Consult State Land Waste Management Authority for disposal.
· Discharge contents of damaged aerosol cans at an approved site.
· Al ow smal quantities to evaporate.
· DO NOT incinerate or puncture aerosol cans.
· Bury residues and emptied aerosol cans at an approved site. Section 14 - TRANSPORTATION INFORMATION
Labels Required: FLAMMABLE GASHAZCHEM: None (ADG6) Land Transport UNDG:
Air Transport IATA:
Maritime Transport IMDG:
Section 15 - REGULATORY INFORMATION
POISONS SCHEDULE: None
REGULATIONS
Ultracolor Aerosol Survey Marker (CAS: None):No regulations applicable Regulations for ingredientstoluene (CAS: 108-88-3) is found on the fol owing regulatory lists; Australia - Australian Capital Territory - Environment Protection Regulation: Ambient environmental standards (Domestic water supply - organic compounds) Australia - Australian Capital Territory - Environment Protection Regulation: Pol utants entering waterways taken to cause environmental harm (Aquatic habitat) Australia - Australian Capital Territory Environment Protection Regulation Ecosystem maintenance - Organic chemicals - Non-pesticide anthropogenic organics Australia - Australian Capital Territory Environment Protection Regulation Pol utants entering waterways - Domestic water quality Australia Exposure Standards Australia Hazardous Substances Australia High Volume Industrial Chemical List (HVICL) Australia Il icit Drug Reagents/Essential Chemicals - Category III Australia Inventory of Chemical Substances (AICS) Australia National Pol utant Inventory Australia Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP) - Appendix E (Part 2) Australia Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP) - Appendix F (Part 3) Australia Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP) - Appendix I Australia Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP) - Schedule 5 Australia Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP) - Schedule 6 GESAMP/EHS Composite List of Hazard Profiles - Hazard evaluation of substances transported by ships IMO IBC Code Chapter 17: Summary of minimum requirements IMO MARPOL 73/78 (Annex II) - List of Noxious Liquid Substances Carried in Bulk IMO Provisional Categorization of Liquid Substances - List 1: Pure or technical y pure products International Agency for Research on Cancer (IARC) Carcinogens OECD Representative List of High Production Volume (HPV) Chemicals OSPAR List of Chemicals for Priority Action United Nations Convention Against Il icit Traffic in Narcotic Drugs and Psychotropic Substances - Table II United Nations List of Precursors and Chemicals Frequently used in the Il icit Manufacture of Narcotic Drugs and Psychotropic Substances Under International Control - Table II WHO Guidelines for Drinking-water Quality - Guideline values for chemicals that are of health significance in drinking-water titanium dioxide (CAS: 13463-67-7) is found on the fol owing regulatory lists; Australia Exposure Standards Australia High Volume Industrial Chemical List (HVICL) Australia Inventory of Chemical Substances (AICS) Australia Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP) - Schedule 4 Australia Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP) - Schedule 5 Australia Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP) - Schedule 7 Australia Therapeutic Goods Administration (TGA) Substances that may be used as active ingredients in Listed medicines Australia Therapeutic Goods Administration (TGA) Sunscreening agents permitted as active ingredients in listed products CODEX General Standard for Food Additives (GSFA) - Additives Permitted for Use in Food in General, Unless Otherwise Specified, in Accordance with GMP GESAMP/EHS Composite List of Hazard Profiles - Hazard evaluation of substances transported by ships IMO IBC Code Chapter 17: Summary of minimum requirements International Agency for Research on Cancer (IARC) Carcinogens OECD Representative List of High Production Volume (HPV) Chemicalstitanium dioxide (CAS: 1317-70-0) is found on the fol owing regulatory lists; Australia Inventory of Chemical Substances (AICS) OECD Representative List of High Production Volume (HPV) Chemicalstitanium dioxide (CAS: 1317-80-2) is found on the fol owing regulatory lists; Australia Inventory of Chemical Substances (AICS) Australia Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP) - Schedule 4 Australia Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP) - Schedule 5 Australia Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP) - Schedule 7 OECD Representative List of High Production Volume (HPV) Chemicalstitanium dioxide (CAS: 1309-63-3) is found on the fol owing regulatory lists; Australia Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP) - Schedule 4 Australia Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP) - Schedule 5 Australia Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP) - Schedule 7titanium dioxide (CAS: 62338-64-1) is found on the fol owing regulatory lists; Australia Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP) - Schedule 4 Australia Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP) - Schedule 5 Australia Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP) - Schedule 7 calcium carbonate (CAS: 471-34-1) is found on the fol owing regulatory lists; Australia High Volume Industrial Chemical List (HVICL) Australia Inventory of Chemical Substances (AICS) Australia Therapeutic Goods Administration (TGA) Substances that may be used as active ingredients in Listed medicines CODEX General Standard for Food Additives (GSFA) - Additives Permitted for Use in Food in General, Unless Otherwise Specified, in Accordance with GMP GESAMP/EHS Composite List of Hazard Profiles - Hazard evaluation of substances transported by ships IMO IBC Code Chapter 17: Summary of minimum requirements International Council of Chemical Associations (ICCA) - High Production Volume List OECD Representative List of High Production Volume (HPV) Chemicalscalcium carbonate (CAS: 1317-65-3) is found on the fol owing regulatory lists; Australia Exposure Standards Australia Inventory of Chemical Substances (AICS) OECD Representative List of High Production Volume (HPV) Chemicals hydrocarbon propel ant (CAS: 68476-85-7) is found on the fol owing regulatory lists; Australia Exposure Standards Australia Hazardous Substances Australia High Volume Industrial Chemical List (HVICL) Australia Inventory of Chemical Substances (AICS) OECD Representative List of High Production Volume (HPV) Chemicalshydrocarbon propel ant (CAS: 68476-86-8) is found on the fol owing regulatory lists; Australia Hazardous Substances Australia Inventory of Chemical Substances (AICS) OECD Representative List of High Production Volume (HPV) Chemicals No data available for titanium dioxide as CAS: 12188-41-9, CAS: 100292-32-8, CAS: 101239-53-6, CAS: 116788-85-3, CAS: 12000-59-8, CAS: 12701-76-7, CAS: 12767-65-6, CAS: 12789-63-8, CAS: 1344-29-2, CAS: 185323-71-1, CAS: 185828-91-5, CAS: 188357-76-8, CAS: 188357-79-1, CAS: 195740-11-5, CAS: 221548-98-7, CAS: 224963-00-2, CAS: 246178-32-5, CAS: 252962-41-7, CAS: 37230-92-5, CAS: 37230-94-7, CAS: 37230-95-8, CAS: 37230-96-9, CAS: 39320-58-6, CAS: 39360-64-0, CAS: 39379-02-7, CAS: 416845-43-7, CAS: 494848-07-6, CAS: 494848-23-6, CAS: 494851-77-3, CAS: 494851-98-8, CAS: 55068-84-3, CAS: 55068-85-4, CAS: 552316-51-5, CAS: 767341-00-4, CAS: 97929-50-5, CAS: 98084-96-9.
No data available for calcium carbonate as CAS: 13397-26-7, CAS: 15634-14-7.
Section 16 - OTHER INFORMATION
INGREDIENTS WITH MULTIPLE CAS NUMBERS
13463-67-7, 1317-70-0, 1317-80-2, 12188-41-9, 1309-63-3, 100292-32-8, 101239-53-6, 116788-85-3, 12000-59-8, 12701-76-7, 12767-65-6, 12789-63-8, 1344-29-2, 185323-71-1, 185828-91-5, 188357-76-8, 188357-79-1, 195740-11-5, 221548-98-7, 224963-00-2, 246178-32-5, 252962-41-7, 37230-92-5, 37230-94-7, 37230-95-8, 37230-96-9, 39320-58-6, 39360-64-0, 39379-02-7, 416845-43-7, 494848-07-6, 494848-23-6, 494851-77-3, 494851-98-8, 55068-84-3, 55068-85-4, 552316-51-5, 62338-64-1, 767341-00-4, 97929-50-5, 98084-96-9 471-34-1, 13397-26-7, 15634-14-7, 1317-65-3 carbonate hydrocarbon 68476-85-7, 68476-86-8 REPRODUCTIVE HEALTH GUIDELINES
» These exposure guidelines have been derived from a screening level of risk assessment and should not be construed as unequivocal y safe limits. ORGS represent an 8-hour time-weighted average unless specified otherwise.
CR = Cancer Risk/10000; UF = Uncertainty factor:TLV believed to be adequate to protect reproductive health:LOD: Limit of detectionToxic endpoints have also been identified as:D = Developmental; R = Reproductive; TC = Transplacental carcinogenJankovic J., Drake F.: A Screening Method for Occupational ReproductiveAmerican Industrial Hygiene Association Journal 57: 641-649 (1996).
» The (M)SDS is a Hazard Communication tool and should be used to assist in the Risk Assessment. Many factors determine whether the reported Hazards are Risks in the workplace or other settings. Risks may be determined by reference to Exposures Scenarios. Scale of use, frequency of use and current or available engineering controls must be considered.

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