Scifinder-powerpoint.pdf

Introduction to Searching
SciFinder Scholar
What is SciFinder Scholar?
Desktop access to databases from CAS
http://www.cas.org/SCIFINDER/SCHOLAR/
Usage Conditions apply
Key Co-Ordinator
What does Scholar Search?
Over 16 million bibliographic records from
over 8,000 journals and from major patent
organizations (from 1967)

Over 22 million chemical substance records
(from 1957)
all classes of substances
Almost 4 million chemical reactions from over
100 journals (from 1985) and from selected
patents (from 1991)

See http://www.cas.org/casdb.html
Coverage of Scholar at VUW
Records in Scholar 1995,
Listed affiliations in Scholar for Departments/
Schools at VUW from 1995 onwards
Some Features of Scholar
Updates daily
Broad coverage across sciences
Desktop access
Automatic truncation/proximity
24 Hour access
Automatic application of synonyms
Bibliographic records from 1967
Structure searching
Reference linking
Reaction searching
substance
bibliographic
reaction
database
database
database
Explore by:
Explore by:
Chemical Name
Research Topic
CAS Registry Number
Molecular Formula
Chemical Structure
Refine by:
Explore by:
- exact or related
Research Topic
Chemical Reaction
- substructure
then Get Reactions
Document Type
Language
Publication Year
Answers are
Answers are
Answers are
chemical substances
bibliographic records
chemical reactions
(CAS Registry Numbers)
Bibliographic Record in Scholar
Title and Bibliography …
… followed by Abstract …
… and Indexing
Exercise 1
Key points
titles and abstracts written by authors
“free text” by authors …
… indexers apply indexing policies
Think how authors and indexers may
have written about your topic
CAS Indexing for Substances
When new information
about a substance is
reported the precise CAS
Registry Number is
potassium in blood
potassium ions in blood
analysis of morphine
analysis of morphine sulfate
Explore by Research Topic
Enter Phrase
Select Candidates
Get References
Interpreting the Research Topic
Prepositions/conjunctions
List of candidates with concepts “closely
associated” and “anywhere”
Combinations of concepts
Truncation/singulars/plurals/”synonyms”/
CAS abbreviations
Adding synonyms at Explore and Refine
AND OR
Distributive modifiers
Look carefully at the list of
candidates to see how Scholar
has interpreted your query
Think!
If unsure, check Table 1
Exercises 2 and 3
“Find information on the use or the
abuse of anabolic steroids”
limit to humans, Reviews, English
language and Publication Year 1996-
print a full record and save all answers
“Find preparations in patents on
dihydrotestosterone”
print full substance record and display a
European Patent
Exercise 4
Find publications by
Daryle H Busch”
(ACS President 1999)
Alternative spellings
Use initial for given name
Explore CAS Registry Number
hyperlinking
Asking the Right Question
Understanding of the
topic
literature
database
Author/Indexer issues
bibliographic databases
(author/indexer)
substance/reaction databases (indexer)
Information on a substance
Comparison of starting with:
Explore by Research Topic
Explore by Chemical Substance/ Substance Identifier then Get
References
Searching for substances by name in Research Topic
searches name/CAS RNs
may lack precision but may aid comprehension
name as part of phrase, auto-truncation, sentence proximity,
need to check that CAS RN has been searched
Searching for information on substances through
Substance Identifier then Get References is precise -
searches CAS RNs

Information on Substances
Balance comprehensiveness with precision
Searches for information on substances can be
conducted in two basic ways and it is important to
realise the benefits/limitations of the options

Sometimes groups of substances are better
retrieved through Explore by Research Topic;
sometimes through Explore by Chemical
Substance

Try options!
Exercise 5
Try your own, or try “I am interested in…”
forensic studies in drug overdose
warning (prediction) of earthquakes
pharmaceuticals for treatment of glaucoma
defense pheromones used by animals
(insects)
studies of DNA of cheetahs (acinonyx)
using satellites for geographic information
systems (GIS)
“I wanted information on inks used
by Gutenberg in his printing press”
although I amended my search to
“I am interested in inks used by
Gutenberg (history, archeology,)”
Explore by Chemical Structure
It is essential that you understand CAS
registration policies for structures!
Most are the same as taught in College
Chemistry Classes although additional
issues include:

Multicomponent substances;
Salts, polymers, mixtures, alloys, hydrates;
Structure connection tables for aromatic
compounds, tautomers, π- and donor-
bonding

Exercise 6
Indexing examples:
ferrocene and π-complexes
dimethyl sulfoxide and donor bonding
augmentin and mixtures
pyridinium tosylate and salts
ABS and co-polymers
Steel 10 and alloys
Exercise 7
Freehand
Shortcuts
User variables
variables
Templates
Ring/chain
Blocking
locking tool
Common atoms
substitution
Drawing
reactions

Exercise 8
Pasting CAS Registry Numbers
Carefully copying a CAS Registry
Number from a record, and pasting
into the structure drawing program …

… offers a very quick alternative to
drawing a structure …

… which may be modified by the
structure drawing tools

Other Structure Drawing Hints
Using Shortcuts
Blocking substitution
Using the locking tool
ring default is isolated/embedded
chain default is ring/chain
Searching Structures: Options
Structure Search Options
Preview Sample Answers allows you to see sample of actual answers
Preview Real-Atom Attachments analyzes answers by atoms attached
to free positions

Exact match or a related structure allows only H-attachments on
structure drawn (related includes multicomponent substances with the
exact match as one component)

Substructure allows substituents at vacant positions
Get Reactions has search options on reaction role, bond/atom
mapping

SUBSTRUCTURE
SUBSTRUCTURE
Structures too general
Structure searching
screen
atom-by-atom match
analyze
display
Very general structures may exceed
system limits
autofix (lock rings/chains)
build more complex structure
Exercise 9
Build structure
Do exact search
Do substructure search (autofix OK)
Get References - reactant
Display
Build reaction query
Search for reactions (autofix OK)
Display
Exercise 10
Using structures to refine substances
Structure refinements of substance
records easily performed
Think of cases where this may be of
special value .
… monochlorotetralins
… radicals, cations, anions
Using research topics to refine references
Substance
Bibliographic
Reaction
database
database
database
Explore by:
Explore by:
Chemical Name
Research Topic
CAS Registry Number
Molecular Formula
Chemical Structure
Refine by:
Explore by:
- exact or related
Research Topic
Chemical Reaction
- substructure
then Get Reactions
Document Type
Language
Publication Year
Answers are
Answers are
Answers are
chemical substances
bibliographic records
chemical reactions
(CAS Registry Numbers)
Conclusion
Information retrieval is a science
Apply scientific method!
observe
explore
understand
think creatively
explore new ideas
Search the literature thoroughly

Source: http://www-organik.chemie.uni-wuerzburg.de/praktika/download/SciFinder-Powerpoint.pdf

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