Prohibited substances&methods 2002_1.pdf

PROHIBITED CLASSES OF SUBSTANCES AND PROHIBITED METHODS
(art. 5 of the Antidoping Examination Regulations/ Adopted by the UCI President on the proposal of the Antidoping Commission of the UCI. UCI List No.01/2002

Entry into effect: 1stMay 2002
2002
PROHIBITED CLASSES OF SUBSTANCES
1. Androgenic anabolising steroids 2. Non-steroidal anabolic agents Peptide hormones, mimetics and analogues PROHIBITED METHODS
Administration of products likely to artificially increase the supply of oxygen or of plasma volume expanders Pharmacological, chemical or physical manipulation CLASSES OF PROHIBITED SUBSTANCES SUBJECT TO CERTAIN CONDITIONS
SUBSTANCES PROHIBITED AT OUT-O F-COMPETITION TESTS
Peptidic hormones, mimetics and analogues The following amphetamines’ related products and stimulants: Compounds chemically or pharmacologically related to the products mentioned under A to C above. This list is based on the list contained the appendix to the Anti-Doping Code of the Olympic Movement, but is not wholly identical. It stays in effect until a new list is published. It is recalled that under the Antidoping Examination Regulations, all products. regardless of denomination, that containing even a minor amount of the above-mentioned substances are prohibited. Warning: the listings of examples in this document are not exhaustive! Numerous substances that are not itemized in this list are considered
prohibited under the designation of ‘related substances’. Riders and other permit -holders must make sure that every drug, supplement,
preparation, particularly if sold over-the counter, as well every other substance they use does not contain any prohibited substance.
Warning: this list relates to a sports regulation. The use of, and traffic in, a number of substances on this list is prohibited or regulated in the
national laws of many countries. Provisions for criminal penalties may be laid down. A substance or method that is not prohibited under the
present list may be prohibited under national law, as for example with regard to cannabinoids.

EXAMPLES AND EXPLANATIONS
CLASSES OF PROHIBITED SUBSTANCES
STIMULANTS
cropropamide (constituant of “Micorene”) crothétamide (constituant of “Micorene”) for caffeine, a sample shall be considered as positive if the concentration in the urine exceeds 12 micrograms/ml; for cathine (norpseudoephedrine) a sample shall be considered as posit ive if the concentration in the urine exceeds 5 micrograms/m l; for ephedrine and methylephedrine, a sample shall be considered as positive if the concentration in the urine exceeds 10 micrograms/m l; for phenylpropanolamine and pseudoephedrine, a sample shall be considered as positive if the concentration in the urine exceeds 25 micrograms/m l. Formoterol, Salbutamol, Salmeterol and terbutaline are permitted in the form of aerosols for the purpose of preventing and/or treating asthma and stress-related asthma: Asthma and/or stress related asthma must be confirmed by a lung specialist or team doctor. The rider must produce a medical
certificate and a prescription issued by a lung specialist or a team doctor during the drug tests (for riders of Trade Teams I and II only
the registration on the health record booklet will be taken into consideration). If he does not comply with this, and the laboratory
finds traces of one of those substances, he will be considered positive. For salbutamol, a concentration of less than 100
nanograms per millilitre will not be taken into consideration.
100ng/ml
NARCOTIC ANALGESICS
* For morphine, a sample shall be deemed positive if the concentration in the urine exceeds 1 microgramme/ml. Codeine, dextromethorphan, dextropropoxyphene, dihydrocodeine, diphenoxylate, ethylmorphine. propoxyphene. trainadoi and pholcodine are permitted. ANABOLIC AGENTS
1 - Androgenic anabolic steroids* dehydrochlormethyltestosterone norethandrolone The Antidoping Commission can have any sample or part of a sample analysed by a Gas-chromatography/Combustion/Isotope Ratio Mass Spectrometry (GC/C/IRMS) in any laboratory which has this apparatus. It will inform the rider about this. If this analysis shows an exogenous application, the rider will be considered positive. In other cases, the Antidoping Commission can ask for further tests. If the rider refuses to undergo these tests, he will be considered positive. For dihydrotestosterone a sample will be considered positive if the concentrations of dihydrotestosterone and its metabolites and/or their ratio of non-5alpha steroids exceed the normal level of a human being in such a way that they cannot be attributed to endogenous production. For nandrolone and its derivatives, a sample will be considered positive if the norandrostcrone concentration found in the urine after hydrolysis exceeds 5 ng/ml. If the concentration is between 2 and 5 ng/ml or is equal to 5 ng/ml, the Antidoping Commission can request further analyses. If the rider refuses to undergo them, he will be considered positive. For analyses other than those performed with a GC/C/IRMS apparatus (see point * above) a sample will be considered positive for testosterone if the level of testosterone/epitestosterone (T/E) is higher than 6. Nevertheless, the rider can request an endocrinological examination to determine if the level is due to a The request for the endocrinological examination must be made to the UCI Antidoping Commission at the latest 5 working days after receipt of the registered letter to the rider’ s national federation informing it of the positive result, i.e. within the deadline for the request of a counter-analysis (article 64 AER). The Antidoping Commission will decide which laboratory and date will be chosen for the analysis. The cost of the analysis must be paid in advance by the rider. The date of the analysis cannot be postponed. If the results of the endocrinological examination show that that the level of T/E is owing to a physiological or pathological state, the UCI will refund the rider the cost of the examination and issue him with a certificate. In all other cases the cost of the examination is to be paid by the rider. If the rider requests a counter-analysis, he must do so within the deadline stipulated in article 64 AER, even if he requests an endocrinological examination. If the counter-analysis does not confirm a positive result , the rider will not be considered positive and the endocrinological examination will not be conducted. Instead of an endocrinological examination, the rider can request, within the same deadline, that the Antidoping Commission carries out a retrospective analysis of previous results, which should be addressed to the Commission within 3 working days of the request. If the Antidoping Commission judges that the request is not valid, it may oblige the rider to have an endocrin ological examination. If the rider refuses, he is considered positive. If the circumstances are justifiable, the Antidoping Commission may immediately propose a retrospective analysis. The Antidoping Commission may also demand a long-term examination consisting of random tests conducted during a period. which it will determine. 2 - Non-steroi idol anabolic agents * Except with a therapeutical justification for use by inhaling as described under point I. A. 1; for salbutamol a sample shall be considered as positive in the class of anabolic agents if the concentration in the urine exceeds 1000 nanograms per millilitre. DIURETICS
PEPTIDE HORMONES, MIMETICS AND ANALOGUES
Chorionie Gonadotrophin (h.C.G. - Human Chorionic Gonadotrophin – prohibited in males only): it is well known that the
administration of human chorionic gonadotrophin and other related compounds leads to an increase in the production of natural
androgenic steroids and is considered equivalent to the exogenous administration of testosterone.
A sample would be considered positive if the concentration is above 20 ImU/ml. During the analysis, two different immunoassays
methods are requested;
(h.C.G. –
Pituitary and synthetic gonadotrophins (LH - prohibited in males only);
Corticotrophin (A.C.T.H., tetracosactide): corticotrophin has been misused to increase the levels of endogenous corticosteroids
in the blood, particularly to obtain the mood-elevating effect of corticosteroids. The administration of corticotrophin is regarded as
equivalent to the oral, intramuscular or intravenous administration of corticosteroids. (See section III. C);
A.C.T.H.
Growth Hormone (h.G.H. Somatotrophin): The use of growth hormone in sport is regarded as amoral and dangerous by reason
of its various side-effects such as allergic reactions, diabetogenic effects, and acromegaly when administered in large doses:
Insulin-like Growth Factor (IGF-l);
Erythropoietine (EPO): a glycoproteinic hormone produced in the human kidney which regulates, apparently by retroaction, the
rate of synthesis of erythrocytes;
Insulin: Permitted only to treat insulin-dependent diabetes. The rider must produce a medical certificate issued by an
endocrinologist or team doctor, certifying his condition as an insulin-dependent diabetic (for riders of Trade Teams I and II only the
registration on the health record booklet will be taken into consideration);
Also prohibited for males are clomiphene, cyclofenil, tamoxifen and aromatase inhibitors.

Without prejudice to the concentration stipulated for h.C.G., the presence of an abnormal concentration of an endogenous hormone in class
(E) or its diagnostic marker(s) in the urine of a competitor constitutes an offence unless it has been proven to be due to a physiological or
pathological conditio n.
PROHIBITED METHODS
Blood doping
Blood doping is the administration of blood, red blood corpuscles or related substances to an athlete except for proven medical need. This procedure may be preceded by taking blood from the athlete, who then continues his training in a state of lacking sufficient blood. Blood transfusion is the intravenous administration of red blood corpuscles or blood compounds containing red corpuscles. These products may be obtained from blood extracted either from the same individual (auto-transfusion) or from different individuals (hetero-transfusion). The most common indicator for the transfusion of red blood corpuscles in current traditional medicine is a large blood loss or severe anaemia. Except where there is a clear medical indication, blood transfusion constitutes doping. Administration of products likely to artificially increase the supply of oxygen or of plasma volume expanders
Apart from the fact that these are prohibited methods, it is worth stressing the risk s associated with the transfusion of blood, blood products or products likely to artificially increase the supply of oxygen (for example RSR-13, PFC or synthetic haemoglobin). These risks include the development of allergic reactions (skin rashes, fevers. etc.) and also acute haemolytic reactions with kidney damage if an incorrect blood type is used, as well as delayed reactions to transfusion such as fever or jaundice, the transmission of infectious diseases (viral hepatitis and AIDS), the overloading of the circulatory system and metabolic shock. The terms plasma volume extenders are understood to mean, for example, gelatine solutions, polysaccharide solutions (for example hydroxyethylamidon [HEA], dextran), albumin-based solutions. Pharmacological, chemical or physical manipulation
The use of substances and methods, including masking agents, which alter, try to alter, or carry a reasonable risk of altering the integrity and validity of urine. Prohibited methods: for example, but not an exhaustive list : catheterization, the substitution and/or alteration of urine, the alteration of renal excretion, the alteration of measurements taken on testostetone and epitestosterone. Prohibited substances: for example, but not an exhaustive list: probenecide and related compounds, epitestosterone, bromantan. If the concentration of epitestosterone is above 200 ng/ml, laboratories are requested to notify the authorities concerned. The Antidoping Commission recommends in this event that additional checks be carried out. CLASSES OF PROHIBITED SUBSTANCES SUBJECT TO CERTAIN CONDITIONS
Marijuana and other cannabinoids
Marijuana is prohibited in the “downhill” discipline in MTB, where a sample will be declared positive if the concentration exceeds 40 ng/ml of THC-COOH (main metabolite of cannabis). Local anaesthetics
The use of local anaesthetics is only permitted on the following conditions: 1. it must be justified on medical grounds, 2. its application must be local, 3. in case of injection, it must be local, e.g. intra-articular, 4. the use of cocaine is prohibited: a different anaesthetic must be used, such as procaine, xylocaine, carbocaine, bupivacaine, lidocane, Justification on medical grounds and the method of application must be proved by the rider in the form of a medical certificate; for riders of Trade Teams I and II only the registration on the health record booklet will be taken into consideration. Apart from conditions cited above, the use of local anaesthetics is prohibited. Thus systemic use and, for example, intramuscular injection are prohibited. Glucocorticosteroids
The use of glucocorticosteroids is only permitted on the following conditions: A) if the application is local: auri cular, ophthalmologic or dermatological or local injection (e.g. intra-articular); in case of
justification for asthma or allergic rhinitis, it can be used by inhalation:

1. it must be justified on medical grounds
2. justification on medical grounds and the method of application must be proved by the rider in the form of a medical certificate;
for riders of Trade Teams I and II, only the registration on the health record booklet will be taken into consideration.

B) if the application is systemic:

1. it must be justified on medical grounds
2. a document must be presented to the UCI Anti -Doping Commission
3. the consent of the Anti -Doping Commission must be obtained except if the medical urgency is incompatible with the consent,
this written consent must be obtained before the application
4. the application must be registered in the health record booklet.
5. the above procedure must be followed in case of treatment renewal
Except for the conditions cited above, the use of glucocorticosteroids is prohibited.
For any questions with respect to this list, members of the Antidoping Commission must be contacted by telephone or facsimile. The
addresses of the members of the Antidoping Commission are as follows:

Werner GOEHNER
- President
Dr. Alain CALVEZ
81245 MUNICH - Germany
44000 NANTES - France

Dr. Leon B.J.A. SCHATTENBERG
Medical Doctor
Geerstraat 5
6447 CB MERKELBEEK - Netherlands
Tel :

Source: http://jcf.or.jp/jp2/rule/UCI_Rule_2004/ProhibitedClassOfSubstances.pdf