Resume (urban theme)

Gunnar Kratz MD, PhD
Professor of Plastic Surgery


Eftergymnasiala utbildningar:

Militärtjänst: K4, Arvidsjaur; 1982-1983.
Läkarexamen; 1991, Karolinska Institutet.
Legitimerad läkare; 1993.

Medicine doktorsgrad; 1993. Avhandling: In vitro studies on keratinocyte derived growth factors,
amniotic fluid and insulin like growth factors in cell proliferation and re-epithelialization of wounds,
Handledare: Carl-Johan Dalsgaard och Anders Haegerstrand
Post-doc; 1995: Post-doc fellow vid Harvard Medical School / Shriner's Burns Institute / Massachusetts
General Hospital, Boston, USA. Värd: Prof. Carolyn Compton.

Specialist i plastikkirurgi; 1997
Docent i ämnet plastikkirurgi; 1997.
Har genomgått ett flertal ledarskapsutbildningar, projektledarutbildningar samt pedagogiska
utbildningar.


Arbetslivserfarenhet:

Nuvarande anställning sedan 2002: Professor i hand- and plastik kirurgi/Överläkare i plastikkirurgi.
Linköpings universitet/Universitetssjukhuset i Linköping.
Tidigare anställningar av intresse för den sökta tjänsten:
1990-1993: Allmäntjänstgöring samt underläkaretjänst, kirurgiska kliniken, Karolinska Sjukhuset,
Stockholm.
1993-1997: Specialistutbildning, Plastikkirurgiska kliniken. Karolinska sjukhuset, Stockholm.
1997-1998: Specialistläkare, Plastikkirurgiska kliniken, Karolinska sjukhuset, Stockholm.
1998-2000: Överläkare samt forskningsansvarig, plastikkirurgiska kliniken, Karolinska sjukhuset,
Stockholm. Ansvarig för laboratoriet för experimentell plastikkirurgi
2000-2002: Överläkare samt lektor, plastikkirurgiska kliniken, Karolinska sjukhuset, Stockholm. Ansvarig
för laboratoriet för experimentell plastikkirurgi samt klinikens totala forskningsaktivitet.
Föräldraledighet: Jan-feb 2004
Gunnar Kratz MD, PhD Professor of Plastic Surgery
Forskningsmeriter:
Handledare för examinerade forskningsstuderande:
Karin Hehenberger 1997
Magdalena Fossum 2004
Fredrik Huss 2005
Carl-Johan Gustafson 2006
Camilla Fredriksson 2008
Johan Junker 2009
Lisa Karlsson 2009
Sofia Pettersson 2009
Pehr Sommar 2010
Birgitta Svernlöv 2011

Pågående handledarskap för forskningsstuderande:
Huvudhandledare (100 %): 3 stycken
Bihandledare (50 %): 1 stycken
Värd för post-docs:
Hans Johnson, 2003-2005
Fredrik Huss, 2007
Opponent vid disputationer:
Tor Sävsjö, Malmö
Margareta Lirvall, Linköping
Elisabeth Björntorp-Mark, Gothenburg
Al Varol, The University of New South Wales, Australia
Maik Stiehler, University of Aarhus, Denmark
Kim Alexander Tönseth, Oslo, Norway
Sofi Forsberg, Uppsala
Björn Schönmayer, Lund
Ola Borgquist, Lund
Kristo Nuutila, Helsinki, Finland
Övrigt:

Förtroendeuppdrag (exempel):
Ordförande i Svensk plastikkirurgisk förening. 2012-pågående Vetenskapligt råd, Inspektionen för vård och omsorg/Socialstyrelsen. 2010-pågående Medlem av editorial boards i Scand J of Surgery, Organogenesis and Läkartidningen. 2003-pågående Medlem i två vävnadsområdes grupper (Vävnadsdirektivet). 2006-pågående Medlem i styrelsen för rekonstruktionscenter, Universitetetssjukhuset, Linköping. 2002-2009 Medlem i anställningsnämnden vid medicinska fakulteten, Linköpings universitet. 2008-2011 Vetenskapligt råd, Mölnlycke Health Care AB. 2004-2011 Medlem i expertgruppen i samband med socialstyrelsens implementering av europeiska direktiven beträffande användandet av humana celler och vävnader. 2002-2005 Gunnar Kratz MD, PhD Professor of Plastic Surgery Proprefekt, institutionen för biomedicin och kirurgi (IBK), Linköpings universitet. 2004-2006

Inbjuden föreläsare (exempel):
Italian Urologic Assocation, Ancona, 2000
Pittsburgh initiative for tissue engineering 2001
National University of Singapore, 2002
Mark Evans International Meeting-Tissue Engineering 2003
KOL meeting on wound healing, Amsterdam, 2004
European Urology Association, annual meeting, Wien 2004
The Royal Swedish Academy of Engineering Sciences, Stockholm 2004
Acta Chirurgica Jubilee lectures, Stockholm 2005
The dermatological society in Sweden, Gothenburg 2005
The Nordic Urology Society, Gothenburg 2005
European Tissue Repair Society16th Annual Meeting, Pisa, Italy 2006
Visiting Professor/Invited Speaker, Harvard Medical School, Boston 2006
Stem Cell and Tissue Engineering in Plastic Surgery, Samsun, Turkey 2007
Swedish National meeting of endocrinologists 2010
The 34th congress of the Scandinavian Association of Plastic Surgeons. 2012.
Astellas Scientific roadshow 2013
Bidrag som entreprenör:
Har grundat företagen: Karocell Tissue Engineering AB and Kratz Medical AB.

Publikationer:

Referee-granskade originalartiklar:
G. Kratz. In vitro studies on keratinocyte derived growth factors, amniotic fluid and insulin like growth
factors in cell proliferation and re-epithelialization of wounds. Thesis.

G. Kratz, A. Hægerstrand, C-J Dalsgaard. Conditioned medium from cultured human keratinocytes has
growth stimulatory properties on different human cell types. J Invest Dermatol 1991; 97:1039-1043.

G. Kratz, M. Lake, K. Ljungström, G. Forsberg, A. Hægerstrand, M. Gidlund. Effect of recombinant IGF
binding protein-1 on primary cultures of human keratinocytes and fibroblasts: Selective enhancement of
IGF-1 but not IGF-2-induced cell proliferation. Exp Cell Res 1992; 202:381-385.
G. Kratz, A. Hægerstrand, B. Palmer. Growth stimulatory effects of amniotic fluid on human cells related to
wound healing. Eur J Plast Surg. 1993;16:130-133.
G. Kratz, M. Lake, M. Gidlund. Insulin like growth factor-1 and-2 and their role in the re-epithelialisation of
wounds; interactions with insulin like growth factor binding protein type 1. Scand J Plast Reconstr Hand
Surg 1994; 28:107-112.
G. Kratz, B. Palmer, A. Hægerstrand. Effects of keratinocyte conditioned medium, amniotic fluid and EGF
in reepithelialization of human skin wounds in vitro. Eur J Plast Surg 1995:18:209-213.
G. Kratz, K. Jansson, M. Gidlund, A Hægerstrand. Keratinocyte conditioned medium stimulates type IV
collagenase synthesis in cultured human keratinocytes and fibroblasts. Br J Dermatol 1995:133;.842-846. Gunnar Kratz MD, PhD Professor of Plastic Surgery I Mitsuse, G Kratz, A Hægerstrand, M Ståhle-Bäckdahl. Collagenase expression is rapidly induced in ulcer
edge keratinocytes after acute injury in human skin; persists during healing and stops at re-epithelialization.
J Invest Dermatol 1995:104;479-483.
K Jansson, G Kratz, A Hægerstrand. Characterization of a new in vitro model for studies of
reepithelialization in human partial thickness wounds. In Vitro Cell Dev Biol-Animal 1996:32;534-540
G. Kratz, B. Jonzon, A. Hultgård-Nilsson, A. Hægerstrand. Characterization and partial purification of a
keratinocyte derived growth factor with wound healing properties. Cell Biochem. 1997:15;153-162.

P Emanuelsson, G Kratz. Characterization of a new in vitro burn wound model. Burns 1997:23;32-36.
G Kratz, C Arnander, J Swedenborg, M Back, C Falk, I Gouda, O Larm. Heparin-chitosan complexes
stimulate wound healing in human skin. Scand J Plast Reconstr Hand Surg, 1997:31; 119-123.
K Hehenberger, K Brismar, F Lind, G Kratz. Dose-dependent hyperbaric oxygen stimulation of cell
proliferation in human fibroblasts derived from normal skin and chronic diabetic foot ulcers. Wound Healing
and Regeneration 1997:5;147-150.

G Kratz, CC Compton. Tissue expression of transforming growth factor-beta 1 and alpha during wound
healing in human skin explants. Wound Healing and Regeneration 1997: 5: 222-8.

K Hehenberger, G Kratz, A Hansson, K Brismar. Fibroblasts derived from human chronic diabetic wounds
have a decreased proliferation rate, which is recovered by the addition of heparin. J Dermatol Sci
1998:16;144-151
C-J Gustafson, Jan Eldh, G Kratz. Culture of human urothelial cells on a cell-free dermis for
autotransplantation. Eur Urol 1998:33;503-506.

G Kratz. Modeling of wound healing processes in human skin using tissue culture. Microsc Res Tech
1998:42;345-350.

Compton CC, Warland G, Kratz G. Melanocytes in Cultured Epithelial Grafts
Are Depleted with Serial Subcultivation and Cryopreservation: Implications
for Clinical Outcome. J Burn Care Rehabil 1998;19:330-336.
G Kratz, C Arnander, M Back, O Larm. Immobilized heparin accelerates the healing of human wounds in
vivo. Scand J Plast Reconstr Hand Surg, 1998;32:381-385.
C-J Gustafson, G Kratz. Cultured autologous keratinocytes on a cell free dermis in the treatment of full-
thickness wounds. Burns, 1999:25;331-335.
E Morcos, OT Jansson, J Adolfsson, G Kratz, NP Wiklund. Endogenously formed nitric oxide modulates cell
growth in bladder cancer cell lines. Urology 1999; 53:1252-1257.

R Rigler, A Pramanik, P Jonasson, G Kratz, O. T. Jansson, P-Å Nygren, S Ståhl, K Ekberg, B-L Johansson, S
Uhlén, M Uhlén, H Jörnvall, J Wahren. Specific binding of proinsulin C-peptide to human cell membranes.
Proc Natl Acad Sci U S A, 1999;96:13318-23.
Kratz, C-J Gustafson, F Huss, E Neovius. Recreation of tissue--the plastic surgeon's spring-board in to the
21st century. Lakartidningen 1999:44.
C Kratz, A Tollbäck, G Kratz. Effects of stretching on cell proliferation in human burn scars. Scand J Plast
Reconstr Hand Surg, 2001;35:57.
C Gustafson, G Kratz. Tissue engineering in urology. Curr Opin Urol. 2001:11; 275-279.
Gunnar Kratz MD, PhD Professor of Plastic Surgery Huss FR, Kratz G. Mammary epithelial cell and adipocyte co-culture in a 3-D matrix: the first step towards
tissue-engineered human breast tissue. Cells Tissues Organs. 2001;169(4):361-7.

Jansson K, Haegerstrand A, Kratz G. A biodegradable bovine collagen membrane as a dermal template for
human in vivo wound healing Scand J Plast Reconstr Surg Hand Surg. 2001 Dec;35(4):369-75.

Huss FR, Kratz G. Adipose tissue processed for lipoinjection shows increased cellular survival in vitro when
tissue engineering principles are applied. Scand J Plast Reconstr Surg Hand Surg. 2002;36(3):166-71.
Fossum M, Gustafson CJ, Nordenskjold A, Kratz G. Isolation and in vitro cultivation of human urothelial
cells from bladder washings of adult patients and children. Scand J Plast Reconstr Surg Hand Surg.
2003;37(1):41-5.

Heilborn JD, Nilsson MF, Kratz G, Weber G, Sorensen O, Borregaard N, Stahle-Backdahl M. The
Cathelicidin Anti-Microbial Peptide LL-37 is Involved in Re-Epithelialization of Human Skin Wounds and is
Lacking in Chronic Ulcer Epithelium. J Invest Dermatol. 2003 Mar;120(3):379-89.
G Kratz, S Asko-Seljvaara. Plastic surgery. Scand J Surg. 2003;92(4):239.

E Neovius, G Kratz. Tissue-engineering by co-cultivating human elastic chondrocytes and keratinocytes in
fibrin glue. Tissue Engineering. Tissue engineering 2003:9; 365-369.

G Kratz, F Huss. Tissue engineering-body parts from the Petri dish. Scand J Surg. 2003;92:241-7.
ightning injuries--a mixture of electrical, thermal and
multiple trauma Lakartidningen. 2004 Jul 8;101(28-29):2328-31.
Engineering of multilayered urinary tissue in vitro. Tissue Eng. 2004
Jan-Feb;10(1-2):175-80. Body parts from the laboratory bench. Br J Surg. 2005 Apr;92(4):385-6.
E Ulfarsson, A Karström, S Yin, A Girnita, D Vasilcanu, M Thoren, G Kratz, J Hillman, M Axelson, O
Larsson, L Girnita. Expression and growth dependency of the insulin-like growth factor I receptor in
craniopharyngioma cells: a novel therapeutic approach.
Clin Cancer Res. 2005 Jul 1;11(13):4674-80.
Fossum M, Lundberg F, Holmberg K, Schoumans J, Kratz G, Nordenskjold A. Long-term culture of human
urothelial cells-a qualitative analysis. Cells Tissues Organs. 2005;181(1):11-22.
Garvin S, Nilsson UW, Huss FR, Kratz G, Dabrosin C. Estradiol increases VEGF in human breast studied by
whole-tissue culture. Cell Tissue Res. 2006 Mar 28
Kratz G. Facial transplantation, playground or medical achievement?
Lakartidningen. 2007 Jan 24-30;104(4):204-5.
M. Fossum, J. Svensson, G. Kratz, A. Nordenskjöld. Autologous in vitro cultured urothelium in hypospadias
repair. Journal of Pediatric Urology 2007 ; 3: 10-18.
Huss FR, Junker JP, Johnson H, Kratz G. Macroporous gelatine spheres as culture substrate,
transplantation vehicle, and biodegradable scaffold for guided regeneration of soft tissues. In vivo study in
nude mice. J Plast Reconstr Aesthet Surg. 2007;60(5):543-55.
Gustafson CJ, Birgisson A, Junker J, Huss F, Salemark L, Johnson H, Kratz G. Employing human
keratinocytes cultured on macroporous gelatin spheres to treat full thickness-wounds: an in vivo study on
athymic rats. Burns. 2007 Sep;33(6):726-35. Epub 2007 Apr 30.
Gunnar Kratz MD, PhD Professor of Plastic Surgery Junker JP, Kratz C, Tollbäck A, Kratz Gurns. 2008 Nov;34(7):942-6. Epub 2008 May 8.
Fredriksson C, Kratz G, Huss F. Transplantation of cultured human keratinocytes in single cell suspension:
a comparative in vitro study of different application techniques. Burns. 2008 Mar;34(2):212-9.
ika Nyman; Carl-Johan Gustafson; Katrin Gisselfält; Elisabeth LiljenstCharacterization of a new degradable polymer scaffold for regeneration of the dermis: In vitro and in vivo
human studies. Organogenesis, Vol 4(2008): s. 195 – 200.
Pettersson S., Wetterö J., Tengvall P., Kratz G. Human articular chondrocytes on macroporous gelatin
microcarriers form structurally stable constructs with blood-derived biological glues in vitro. J Tissue Eng
Regen Med. 2009 Aug;3(6):450-60.
L.K. Karlsson, J.P.E. Junker, M. Grenegård, G. Kratz. Human Dermal Fibroblasts: a Potential Cell Source for Endothelialization of Vascular Grafts. Ann Vasc Surg. 2009 Sep-Oct;23(5):663-74.
Fredriksson C, Kratz G, Huss F. Accumulation of silver and delayed wound healing in human skin: an ex
vivo study of different silver dressings. Wounds 2009. Volume 21 - Issue 5 - May, 2009.

Sommar P, Pettersson S, Ness C, Johnson H, Kratz G, Junker JPJ Plast
Reconstr Aesthet Surg. 2010 Jun;63(6):1036-46
Fredrik R.M. Huss, Erika Nyman, Johanna S Bolin, Gunnar Kratz. Use of macroporous gelatine spheres as
a biodegradable scaffold for guided tissue regeneration of healthy dermis in humans: an in vivo study, J Plast
Reconstr Aesthet Surg. 2010 May;63(5):848-57.

Junker J, Sommar P, Skog M, Johnson H, Kratz G. Adipogenic, Chondrogenic and Osteogenic Differentiation
of Human Dermal Fibroblasts. Cells Tissues Organs. 2010;191(2):105-18.
Tønseth KA, Bjark T, Kratz G, Gross A, Kirschner R, Schreiner T, Diseth TH, Haraldsen I. Sex reassignment
surgery in transsexuals. Tidsskr Nor Laegeforen. 2010 Feb 25;130(4):376-9.
H Seland, C-J Gustafson, H Johnson, JP Junker, G Kratz. Transplantation of acellular dermis and
keratinocytes cultured on porous biodegradable microcarriers into full-thickness skin injuries on athymic
rats. Burns, 2011 Feb;37(1):99-108.
Pettersson S, Wetterö J, Tengvall P, Kratz G. Cell expansion of human articular chondrocytes on
macroporous gelatine scaffolds-impact of microcarrier selection on cell proliferation. Biomed Mater. 2011
Dec;6(6):065001.

Rakar J, Lönnqvist S, Sommar P, Junker J, Kratz G.
Interpreted gene expression of human dermal fibroblasts after adipo-, chondro- and osteogenic phenotype
shifts. Differentiation. 2012 Nov;84(4):305-13. Epub 2012 Sep 27.

Nyman E, Huss F, Nyman T, Junker J, Kratz G.
Hyaluronic acid, an important factor in the wound healing properties of amniotic fluid: In vitro studies of re-
epithelialisation in human skin wounds.
J Plast Surg Hand Surg. 2013 Apr;47(2):89-92. 2013 Jan 29.
Sommar P, Junker JP, Strandenes E, Ness C, Hansson T, Johnson H, Kratz G.
Osteogenically-induced human dermal fibroblasts as a tool to regenerate bone.
J Plast Surg Hand Surg. 2013 Feb;47(1):8-13.

Junker JP, Lönnqvist S, Rakar J, Karlsson LK, Grenegård M, Kratz GDifferentiation. 2013 Feb;85(3):67-77.
Gunnar Kratz MD, PhD Professor of Plastic Surgery Jangamreddy JR, Ghavami S, Grabarek J, Kratz G, Wiechec E, Fredriksson BA, Rao Pariti RK, Cieślar-
Pobuda A, Panigrahi S, Łos MJ.
Biochim Biophys Acta. 2013 Sep;1833(9):2057-69.
Böcker och bokkapitel:
Författare till kapitlet “wound healing” i ” Kirurgi” Eds: B Hamberger, U Haglund. Liber. ISBN 91-47-05065
Medförfattare till STRAMAs consensus bok rörande hudinfektioner. Medförfattare till Scandinavian textbook of plastic surgery. Medförfattare till Artificial Organs Series: New Techniques in Surgery Series , Vol. 4 Hakim, Nadey S. (Ed.) 2009, X, 190 p. 64 illus., 53 in color., Hardcover ISBN: 978-1-84882-281-8


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Source: http://www.plastikakademin.se/mop-kratz.pdf