Christina piperi, phd

CHRISTINA PIPERI, PhD


Surname: Piperi
Home address
Forename: Christina
Date of Birth:
Nationality:
Marital status: Married, two children
Tel. +30-210-7462610 office hours
Mobile: +30 6944-318861
FAX. +30-210-8037372
E-mail
ACADEMIC QUALIFICATIONS
1995-1999
PhD in Biochemistry and Molecular Immunology, Sir William Dunn School of Pathology, MRC Cellular Immunology Unit, University of Oxford, UK. BSc honours in Medical Biochemistry, School of Biological Sciences, University of Surrey, Guildford, UK
RESEARCH / PROFESSIONAL POSITIONS
Assistant Professor of Biochemistry in the University of Athens Medical School, Department of Biological Chemistry Postdoctoral Research Scientist at the INSERM ERI 11 Unit, Department of Medical Biochemistry, Faculty of Medicine, University of Nancy, France Lecturer of Biochemistry in the University of Athens Medical School, Department of Biological Chemistry Postdoctoral fellow at the Institute of Biomedical Research and Biotechnology in Athens. Industrial placement in Bayer plc., Slough, UK.
TEACHING EXPERIENCE
Biological Chemistry I (undergraduate course / Medical & Dental School) Biochemistry (undergraduate course / School of Nursing) Topics in Molecular Medicine (undergraduate elective course / Medical School) Clinical Biochemistry (undergraduate elective course / School of Nursing) Graduate Programme in «Minimally Invasive Surgery, Robotic Surgery and Telesurgery» Biochemistry tutor for first year Medical students (University of Oxford Pathology department) for two academic years. Fundamental Immunology for first year Biochemists (University of Oxford Pathology department) for one academic year Practical demonstrator for first and second year Medical students (University of Oxford Pathology department) for three academic years
RESEARCH INTERESTS
- Signal transduction pathways of Advanced Glycation Endproducts (AGEs) in metabolic disorders
(Metabolic syndrome, Diabetes Mellitus, Polycystic Ovarian Syndrome, Osteoporosis)
- Molecular mechanisms of differentiation and carcinogenesis in human cell (pulmonary epithelium,
gliomas, melanomas)
- Cytokine effector mechanisms in autoimmune disorders (Multiple sclerosis), neuroimmunology
(Alzheimer’s disease) and oncology (Gliomas) using ELISPOT methodology
REVIEWER IN SCIENTIFIC JOURNALS

Referee for the Journal Molecular and Cellular Biology
Referee for the Journal Cell Research Referee for the Journal Biochimie Referee for the Journal Clinical Biochemistry Referee for the Journal Human Immunology Referee for the Journal Annals of Internal medicine Referee for the Journal British Medical Journal Referee for the Journal Neurosurgery Referee for The International Journal of Biochemistry & Cell Biology Referee for the Journal Acta Histochemica Referee for the Journal Current Topics in Medicinal Chemistry Referee for The Journal of Applied Physiology Referee for The Journal Analytical Cellular Pathology: Cellular Oncology Referee for The Scandinavian Journal of Clinical & Laboratory Investigation Referee for The Journal of Translational Medicine Research Referee for The American Journal of Pathology Referee for the Journal Current Pharmaceutical Design Referee for the Journal Clinical Lung Cancer Referee for the Journal Cell Biology International

MEMBERSHIP IN SCIENTIFIC SOCIETIES
2012 - : International Society of Maillard Reaction (IMARS)
2009 - : British Neurooncology Group
2007 - : Hellenic Society for Endocrinology
2006 - : Hellenic Society of Lipidology and Atherosclerosis
2006 - : Hellenic Society of Indoor Air Quality
1997 - : British Immunological Society
1995 - : British Biochemical Society
1995 - : British Genetics Society
1995 - : Oxford Immunology Group
1995 - : Oxford Pathology Immunology Group
MOST SIGNIFICANT PUBLICATIONS
1. Dalagiorgou G, Piperi C, Georgakopoulou U, Adamopoulos C, Basdra EK, Papavassiliou AG. 2012.
Mechanical stimulation of polycystin-1 induces human osteoblastic gene expression via potentiation of the
calcineurin/NFAT signalling axis. Under review in JBC (MS ID#: JBC/2012/395046)
2. Piperi C, Adamopoulos C, Dalagiorgou G, Diamanti-Kandarakis E, Papavassiliou AG. Crosstalk between
Advanced Glycation and Endoplasmic Reticulum Stress: Emerging Therapeutic Targeting for Metabolic
Diseases.J Clin Endocrinol Metab. 2012 Apr 16. [Epub ahead of print] * Invited review due to her
previous publications in the field of Advanced glycation
3. Piperi C, Papavassiliou AG. Molecular mechanisms regulating matrix metalloproteinases. Curr
Top Med Chem. 2012 May 1;12(10):1095-112.
4. Gargalionis AN, Piperi C*, Adamopoulos C, Papavassiliou AG. Histone modifications as a
pathogenic mechanism of colorectal tumorigenesis. Int J Biochem Cell Biol. 2012 Aug;44(8):1276-
89. (* Equal contribution with 1st author)
5. Korkolopoulou P, Levidou G, El-Habr EA, Piperi C, et al. Phosphorylated 4E-binding protein 1
(p-4E-BP1): a novel prognostic marker in human astrocytomas. Histopathology. 2012 Jun 13.
6. Korkolopoulou P, Levidou G, El-Habr EA, Adamopoulos C, Samaras V, Zisakis A, Kavantzas N,
Boviatsis E, Fragkou P, Papavassiliou AG, Patsouris E, Piperi C. Expression of interleukin-8
receptor CXCR2 and suppressor of cytokine signaling-3 in astrocytic tumors.Mol Med. 2012 May
9;18(1):379-88.
7. Varela A, Katsiboulas M, Tousoulis D, Politi K, Papaioannou TG, Vaina S, Davos CH, Piperi C,
Stefanadis C, Basdra EK, Papavassiliou AG. Early shear stress signaling on vascular endothelium
by a modified partial carotid ligation model. Int J Cardiol. 2011 Nov 3;152(3):413-6.
8. Christakou C, Economou F, Livadas S, Piperi C, et al. Strong and positive association of
endothelin-1 with AGEs in PCOS: a causal relationship or a bystander? Hormones (Athens). 2011
Oct-Dec;10(4):292-7.
9. Piperi C, Samaras V, Levidou G, Kavantzas N, Boviatsis E, Petraki K, Grivas A, Barbatis C,
Patsouris E, Korkolopoulou P. Prognostic significance of IL-8-STAT-3 pathway in astrocytomas:
Correlation with IL-6, VEGF and microvessel morphometry. Cytokine. 2011 Jun 17.
10. Piperi C, Papavassiliou AG. Strategies for DNA methylation analysis in developmental studies. Dev
Growth Differ. 2011 Apr;53(3):287-99.
11. Diamanti-Kandarakis E, Livadas S, Katsikis I, Piperi C, Mantziou A, Papavassiliou AG, Panidis D.
Serum concentrations of carboxylated osteocalcin are increased and associated with several components of
the polycystic ovarian syndrome. J Bone Miner Metab. 2011 Mar;29(2):201-6.
12. Diamanti-Kandarakis E, Lambrinoudaki I, Economou F, Christou M, Piperi C, Papavassiliou AG,
Creatsas G. Androgens associated with advanced glycation end-products in postmenopausal women.
Menopause. 2010 Nov-Dec;17(6):1182-7.
13. Politis A, Olgiati P, Malitas P, Albani D, Signorini A, Polito L, De Mauro S, Zisaki A, Piperi C, et al.
Vitamin B12 levels in Alzheimer's disease: association with clinical features and cytokine production. J
Alzheimers Dis. 2010;19(2):481-8.
14. Piperi C, Themistocleous MS, Papavassiliou GA, Farmaki E, Levidou G, et al. High incidence of
MGMT and RARbeta promoter methylation in primary glioblastomas: association with histopathological
characteristics, inflammatory mediators and clinical outcome. Mol Med. 2010 Jan-Feb;16(1-2):1-9.
15. Papachristou DJ, Papachroni KK, Papavassiliou GA, Pirttiniemi P, Gorgoulis VG, Piperi C, Basdra EK.
Functional alterations in mechanical loading of condylar cartilage induces changes in the bony subcondylar
region. Arch Oral Biol. 2009 Nov;54(11):1035-45.
16. Drago A, Liappas I, Petio C, Albani D, Forloni G, Malitas P, Piperi C, et al. Epistasis between IL1A,
IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 variations does not impact alcohol dependence disorder features.
Int J Environ Res Public Health. 2009 Jul;6(7):1980-90.
17. Olgiati P, Politis A, Malitas P, Albani D, Dusi S, Polito L, De Mauro S, Zisaki A, Piperi C, et al. APOE
epsilon-4 allele and cytokine production in Alzheimer's disease. Int J Geriatr Psychiatry. 2010
Apr;25(4):338-44.
18. Papachroni KK, Piperi C*, Levidou G, Korkolopoulou P, Pawelczyk L, Diamanti-Kandarakis E,
Papavassiliou AG. J Cell Mol Med. 2009 Jul 6. (*Equal contribution with 1st author)
19. Diamanti-Kandarakis E, Piperi C, Minerva Endocrinol. 2009 Jun;34(2):97-104.
20. Piperi C, Vlastos F, Farmaki E, Martinet N, Papavassiliou AG. Epigenetic effects of lung cancer
predisposing factors: impact on clinical diagnosis and prognosis. J Cell Mol Med. 2008 Mar; 12 (5A):1495-
1501.
21*. Diamanti-Kandarakis E, Katsikis I, Piperi C Clin Endocrinol (Oxf). 2008
Oct;69(4):634-41. (*This is the first research paper revealing increased serum AGE levels in PCOS)
22. Alexandraki KI, Piperi C, et al. J Clin Immunol. 2008 Jul;28(4):314-21.
23. Diamanti-Kandarakis E, Piperi C, et al. Immunohistochemical localization of advanced glycation end-
products (AGEs) and their receptor (RAGE) in polycystic and normal ovaries. Histochem Cell Biol. 2007
24. Diamanti-Kandarakis E, Katsikis I, Piperi C, et al. Effect of long-term orlistat treatment on serum levels
of advanced glycation end-products in women with polycystic ovary syndrome. Clin Endocrinol (Oxf). 2007
Jan;66(1):103-9.
25. Diamanti-Kandarakis E, Alexandraki K, Piperi C, et al. Effect of metformin administration on plasma
advanced glycation end product levels in women with polycystic ovary syndrome. Metabolism. 2007
Jan;56(1):129-34.
26. Diamanti-Kandarakis E, Alexandraki K, Piperi C, et al. Inflammatory and endothelial markers in women
with polycystic ovary syndrome. Eur J Clin Invest. 2006 Oct;36(10):691-7.
27. Diamanti-Kandarakis E, Piperi C. Genetics of polycystic ovary syndrome: searching for the way out of
the labyrinth. Hum Reprod Update. 2005 Nov-Dec;11(6):631-43.

28. Pouli AE, Hatzinikolaou DG, Piperi C, et al. The cytotoxic effect of volatile organic compounds of the
gas phase of cigarette smoke on lung epithelial cells. Free Radic Biol Med. 2003 Feb 1; 34(3):345-55.

29. Bakker TR, Piperi C, Davies EA, Merwe PA. Comparison of CD22 binding to native CD45 and
synthetic oligosaccharide. Eur J Immunol. 2002 Jul; 32(7):1924-32.
30. Van Rossenberg SM, Sliedregt LA, Autar R, Piperi C, et al. A structure-function study of ligand
recognition by CD22beta. J Biol Chem. 2001 Apr 20; 276(16):12967-73.
PUBLICATIONS

•
Publications in international biomedical journals: 85 (78 included in SCI)
Publications in greek medical journals: 6 4 chapters in international biomedical books Total Citations: >750

INVITED TALKS

- Invitation to give a plenary lecture on advanced glycation end products signalling in the International
Maillard Reaction Society (IMARS) Conference to be held in September 2012 in Nancy, France
- 38th Panenhellenic Medical Conference (2012): Pathophysiology of advanced glycation
- 25th Panhellenic Neurosurgery Conference (2011): Cytokine regulation in astrocytomas
-16th Panhellenic Society of Internal Medicine (2010). Title: Lysyl oxidase interacts with AGEs signaling to
modulate collagen synthesis in polycystic ovarian tissue
-10th Panhellenic Conference and 2nd International Conference on Food and Nutrition Science (2009). Title:
Advanced Glycation End products
-XXVIII European Society Section Meeting of the International Society for Heart Research (2008). Title:
Advanced Glycation End products signalling in endothelium
- Press conference in the 87th Annual Meeting of the Endocrine Society (Oral Session: Clinical –
Cardiovascular Endocrinology) San Diego, California, USA regarding the abstract "Endothelial Dysfunction
in Polycystic Ovary Syndrome (PCOS): Its relationship with Markers of Endothelial Activation, Low Grade
Chronic Inflammation and Metabolic Characteristics of PCOS", presented in ENDO 2005 and included in
the ‘ENDO Research Summaries Book’, ENDO
-1ο Panhellenic & International Symposium, Hellenic College of Surgeons (2006). Title: Molecular
therapeutic approaches in gliomas management
- 1st International scientific conference of Εuropean Citizen’s Quality of Life (2003) Title:
Neuroimmunology: A new window of opportunity for Neurodegenerative diseases.
ORGANISATIONAL SKILLS

- Representative of the Division of Basic Medical Sciences Staff in General Meetings of Medical
School of National and Kapodistrian University of Athens (2007-2008)
- Member of the organizational committee of the Graduate program entitled “Applications of Biology in
Medicine” of the Faculty of Biology of National and Kapodistrian University of Athens (2007-2008)
- Member of the organizational committee of the 1st Panhellenic Seminar of Experimental Biomedical
Research, Research and Experimental Center for ELPEN (2007)
- Establishment of Molecular Endocrinology Unit in the Department of Biological Chemistry, National and
Kapodistrian University of Athens (2006-present)
- Establishment of Molecular Immunobiochemical Unit in the Department of Biological Chemistry, National
and Kapodistrian University of Athens. Application of ELISPOT and flow cytometry techniques (2004-
present)
- Member of the organizational committee of the conference ‘50 years of DNA: present and future’, Athens
(2003)
- Development of a novel system for measuring air pollutants, application of novel methodologies for
studying biological consequences of cigarette smoke - Institute of Biomedical Research and Biotechnology
in Athens (1999-2003)
AWARDS – DISTINCTIONS- SCHOLARSHIPS

• 1st Papastamatis award for best biomedical research study (2012) • 1st Award for best poster presentation, 21st Pathology Conference, “Sotiria” Hospital (2012) • L’Oreal-UNESCO award for women in science (2010) • 1st Award, Hellenic Society of Internal Medicine (2010) • 2nd Award, 8th Panhellenic Congress of Allergiology and Clinical Immunology, Athens, Greece • “D. Ikkos” Award, Hellenic Endocrine Society (2009) • “D. Ikkos” Award, Hellenic Endocrine Society (2008) • “I. Giannatos” Award, Hellenic Endocrine Society (2008) • 1st Award in 19th Panhellenic Urology Conference (2008) • The publication entitled « Effect of Long-term Orlistat Treatment on Serum Levels of Advanced Glycation End products in Women with Polycystic Ovary Syndrome by Diamanti-Kandarakis E,
Katsikis I, Piperi C, Alexandraki K, Panidis D, published in Clinical Endocrinology (Oxf). Jan.
2007; 66(1): 103-109» was selected by Nature Clinical Practice Endocrinology & Metabolism as the
most important publication of the year and was reproduced in the Research Highlights' section
• 1st Award in 10th Panhellenic Pathology Conference (2006) • “ Pitouli” Award, Hellenic Endocrinological Society (2004) • Gordon Piller PhD scholarship from British Leukaemia Research Fund (1995)
RESEARCH GRANTS

1. Investigation of the role of Polycystins in Atherosclerosis, Budget: 10000 Euro, EMPEIRIKEION
FOUNDATION, Greece. Position in research Grant: Principal investigator (2011-)
2. Study of signaling pathways of advanced glycation end- products (AGEs) on endothelial and ovarian
cells, Budget: 35000 Euro, HERAKLEITOS II, Hellenic Ministry of Education, Life-time Learning and
Religious Affairs. PI: C. Adamopoulos. Position in research Grant: Supervisor (2011-2013)
3. The Role of Mechanical Load in Treating Osteoporosis: Designing a Mechanical Osteoblast Stimulation
Model to Investigate Curative Application, Budget: 12000 Euro, John S. Latsis Public Benefit Foundation,
Greece. Position in research Grant: Member of research team (2010-2011)
4. Investigation of collagen synthesis regulatory factors in Polycystic Ovarian Syndrome: the role of lysyl
oxidase and of advanced glycation end products, Budget: 5000 Euro, Hellenic Endocrine Society. Position in
research Grant: Member of research team (2009-2011)
5. Impact of diet rich in glytoxin content in the reproductive system of women with Polycystic Ovarian
Syndrome: Nutritional solutions to improve syndrome phenotype. Budget: 12000 Euro, John S. Latsis Public
Benefit Foundation, Greece. Position in research Grant: Member of research team (2009-2010)
6. Impact of oxidative stress in endothelial cell signaling and its effects in embyo-placental axis of women
with Polycystic Ovarian Syndrome. Budget: 5000 Euro, Hellenic Endocrine Society. Position in research
Grant: Member of research team (2008-2010)
7. Investigation of immunobiochemical profile of patients with Alzheimer disease and temporofrontal
dementia and correlation with their psychological state. Budget: 4200 Euro, Pfizer Hellas. Position in
research Grant: Principal investigator (2007-2008)
8. Investigation of dietary factors in female reproductive system: study of intracellular signaling pathways of
Advanced glycation end products. Budget: 2500 Euro, Hellenic Endocrine Society. Position in research
Grant: Member of research team (2007-2009)
9. Investigation of the role and mechanism of action of growth hormone releasing hormone in non-hypopheseal tissues. Budget: 50000 Εuro, PYTHAGORAS II, Hellenic Ministry of Education, Life-time Learning and Religious Affairs, Position in research Grant: Member of research team (2005-2006). 10. Investigation of the molecular mechanisms of primary and secondary gliomagenesis. Budget: 2500 Euro, KAPODISTRIAS, National and Kapodistrian University of Athens. Position in research Grant: Principal investigator (2006-2007). 11. Investigation of molecular mechanisms of gliomagenesis in Greek population: molecular target selection for application of chemosensitivity assays. Budget: 12000 Euro. Hellenic Ministry of Health and Social Solidarity, Oncology research projects. Position in research Grant: Principal investigator (2005-2007) 12. The role and significance of cytokines in multiple sclerosis and application of ELISPOT immunoassay in their detection and evaluation. Budget: 1500 Euro, KAPODISTRIAS, National and Kapodistrian University of Athens. Position in research Grant: Principal investigator (2004-2005). 13. The role of bioinformatics in modern therapeutic and diagnostic approaches in clinical practice and experimental oncology. Budget: 12000 Euro. Hellenic Ministry of Health and Social Solidarity, Oncology research projects. Position in research Grant: Principal investigator (2003-2005)

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